We previously characterized associations between brain imaging measurements of amyloid-β (Aβ) plaque burden and apolipoprotein E (APOE) ϵ4 gene dose in a small number of cognitively unimpaired late-middle-aged APOE ϵ4 homozygotes (HMs), heterozygotes (HTs), and noncarriers (NCs). We now characterize cross-sectional Aβ plaque, tau tangle, and cortical atrophy (neurodegeneration) measurements, Read & Research Alzheimer’s More

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New research in mice suggests that exposure to cadmium can lead to cognitive decline in those with the Alzheimer’s risk gene APOE4. Read & Research Alzheimer’s More

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New research in mice suggests that a leaky blood-brain barrier can accelerate brain aging, and that targeting inflammation can reverse some changes. Read & Research Alzheimer’s More

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CoQ10 is a natural chemical that carries out a many vital roles in the body. Some people may take supplements to correct a CoQ10 deficiency. Read & Research Alzheimer’s More

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The ROADMAP project aimed to provide an integrated overview of European real-world data on Alzheimer’s disease (AD) across the disease spectrum. Read & Research Alzheimer’s More

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Some Alzheimer’s disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment Read & Research Alzheimer’s More

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Relationship between age and dementia at extreme old ages is still an open question, yet population-based studies in this high-risk age segment are rare. Read & Research Alzheimer’s More

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Observational studies have suggested that light-to-moderate alcohol consumption decreases the risk of Alzheimer’s disease, but it is unclear if this association is causal. Read & Research Alzheimer’s More

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A new study in mice finds that extra virgin olive oil prevents the toxic accumulation of tau protein in the brain and keeps memory intact. Read & Research Alzheimer’s More

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Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Read & Research Alzheimer’s More

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Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Read & Research Alzheimer’s More

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A recent study adds to the evidence linking air pollution with cognitive decline. The researchers also suggest a possible underlying mechanism. Read & Research Alzheimer’s More

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Inflammation drives neuron damage by tau protein accumulation in Alzheimer’s and other neurodegenerative brain diseases, according to new research. Read & Research Alzheimer’s More

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Apolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation. Read & Research Alzheimer’s More

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Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. Read & Research Alzheimer’s More

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Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer’s disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay Read & Research Alzheimer’s More

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A 6-year study of 1,000 people aged 70–90 found no difference in rates of memory or cognition decline among participants who did or did not use statins. Read & Research Alzheimer’s More

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We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos. Read & Research Alzheimer’s More

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New research finds that people who cannot read may have a threefold risk of developing dementia in older age, compared with people who can read. Read & Research Alzheimer’s More

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A study of 35 people with and without Alzheimer’s disease found that hyperspectral imaging of the retina could aid early diagnosis of the disease. Read & Research Alzheimer’s More

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Why is my leg shaking?"> Why is my leg shaking?

Posted November 13, 2019 By

There are many reasons a person’s leg could be shaking, from restless legs syndrome to anxiety. Read this article to learn about 10 possible causes of a shaky leg. Read & Research Alzheimer’s More

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In a new review of the evidence, scientists propose two main types of Parkinson’s, depending on which part of the nervous system the disease originates in. Read & Research Alzheimer’s More

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New research examines the cognitive ability of children in the hope that markers of cognitive decline will predict dementia later in life. Read & Research Alzheimer’s More

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The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. Read & Research Alzheimer’s More

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Development of disease-modifying treatments for Alzheimer’s disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, Read & Research Alzheimer’s More

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The first large-scale study of its kind examines the link between waist circumference in later life and the risk of developing dementia. Read & Research Alzheimer’s More

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A new study shows, for the first time, that cerebrospinal fluid washes into and out of the brain in waves during sleep, helping clear out waste. Read & Research Alzheimer’s More

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Multidomain intervention for Alzheimer’s disease (AD) risk reduction is an emerging therapeutic paradigm. Read & Research Alzheimer’s More

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The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer’s disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid β (Aβ) contribute to the onset of AD. Read & Research Alzheimer’s More

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Odor identification deficits characterize Alzheimer’s disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Read & Research Alzheimer’s More

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