In a large-scale study, links between alcohol use disorder and dementia are fleshed out. The relationship is stronger than previously thought. Read & Research Alzheimer’s More

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Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer’s disease (AD) process yields conflicting results. Read & Research Alzheimer’s More

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Higher cardiorespiratory fitness is tied to stronger white matter and better cognitive performance in a study of seniors with mild cognitive impairment. Read & Research Alzheimer’s More

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For the first time, scientists achieve a ‘dramatic reversal’ of Alzheimer’s-related brain damage in mice, offering hope for humans. Read & Research Alzheimer’s More

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New research finds that nicotinamide riboside, which is a form of vitamin B-3, has the potential to treat Alzheimer’s. Results in mice are hopeful. Read & Research Alzheimer’s More

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The socioeconomic costs of Alzheimer’s disease (AD) in China and its impact on global economic burden remain uncertain. Read & Research Alzheimer’s More

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A new study examines the effect of positive and negative attitudes toward aging on the risk of developing dementia among at-risk individuals. Read & Research Alzheimer’s More

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A new study examines the brain structure and memory function of monolingual and multilingual people with Alzheimer’s disease and mild cognitive impairment. Read & Research Alzheimer’s More

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Researchers have uncovered a mechanism by which damage to cells that protect blood vessels may lead to Alzheimer’s, and such damage could begin in our 40s. Read & Research Alzheimer’s More

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Researchers suggest that low levels of alcohol can help to improve the function of the glymphatic system, which is the brain’s waste-clearing process. Read & Research Alzheimer’s More

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The National Plan to Address Alzheimer’s Disease stresses the need for public-private partnerships to be coordinated and cooperative to accelerate the state of research and reach the ultimate goal of preventing and effectively treating Alzheimer’s disease by the year 2025. The private-public partnerships in the Alzheimer’s disease community continue to Read & Research Alzheimer’s More

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This study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death. Read & Research Alzheimer’s More

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We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. Read & Research Alzheimer’s More

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Diffusion tensor imaging detects early tissue alterations in Alzheimer’s disease and cerebral small vessel disease (SVD). However, the origin of diffusion alterations in SVD is largely unknown. Read & Research Alzheimer’s More

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Posted February 1, 2018 By

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The National Institute on Aging and the Alzheimer’s Association (NIA-AA) convened a workgroup in 2016 to develop a new Research Framework to promote novel directions for research based on emerging knowledge and new understanding of AD pathophysiology [1]. Read & Research Alzheimer’s More

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Contents"> Contents

Posted February 1, 2018 By

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Is deep brain stimulation a way forward in treating Alzheimer’s disease? A phase I clinical trial suggests that it can improve cognitive functioning. Read & Research Alzheimer’s More

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People whose brain scans reveal very early preclinical signs of Alzheimer’s disease also have disruptions in their sleep/wake cycles, a new study shows. Read & Research Alzheimer’s More

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Exercise may improve cognition and prevent Alzheimer’s disease, but are some forms of exercise better than others? New research investigates. Read & Research Alzheimer’s More

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Neurofilament light (NFL) levels in the cerebrospinal fluid are increased in several neurodegenerative dementias. However, their diagnostic accuracy in the differential diagnostic context is unknown. Read & Research Alzheimer’s More

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A compound in the popular spice turmeric — called curcumin — has been found to improve the memory and mood of older adults in a new study. Read & Research Alzheimer’s More

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Our laboratories have demonstrated that accumulation of oligomeric amyloid β (OAβ) in neurons is an essential step leading to OAβ-mediated mitochondrial dysfunction. Read & Research Alzheimer’s More

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A new study provides further evidence that exposure to a highly toxic form of amyloid beta injures mitochondria and triggers early events in Alzheimer’s. Read & Research Alzheimer’s More

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Because currently known Alzheimer’s disease (AD) single-nucleotide polymorphisms only account for a small fraction of the genetic variance in this disease, there is a need to identify new variants associated with AD. Read & Research Alzheimer’s More

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We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. Read & Research Alzheimer’s More

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Alzheimer’s disease (AD), the most commonly occurring form of dementia worldwide [1], is characterized by two well-defined pathological “hallmarks”, namely extracellular plaque-like deposits of amyloid β (Aβ) peptide and neurofibrillary tangles made up of hyperphosphorylated tau protein, in the brain tissue from diseased human patients [2]. Read & Research Alzheimer’s More

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New research has linked increasing symptoms of anxiety in older adults to higher brain levels of beta-amyloid, a protein linked to Alzheimer’s disease. Read & Research Alzheimer’s More

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With 36 million older adult U.S. drivers, safety is a critical concern, particularly among those with dementia. It is unclear at what stage of Alzheimer’s disease (AD) older adults stop driving and whether preclinical AD affects driving cessation. Read & Research Alzheimer’s More

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The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1–42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer’s disease dementia (ADD; Read & Research Alzheimer’s More

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