We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. Read & Research Alzheimer’s More

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Alzheimer’s disease (AD), the most commonly occurring form of dementia worldwide [1], is characterized by two well-defined pathological “hallmarks”, namely extracellular plaque-like deposits of amyloid β (Aβ) peptide and neurofibrillary tangles made up of hyperphosphorylated tau protein, in the brain tissue from diseased human patients [2]. Read & Research Alzheimer’s More

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New research has linked increasing symptoms of anxiety in older adults to higher brain levels of beta-amyloid, a protein linked to Alzheimer’s disease. Read & Research Alzheimer’s More

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With 36 million older adult U.S. drivers, safety is a critical concern, particularly among those with dementia. It is unclear at what stage of Alzheimer’s disease (AD) older adults stop driving and whether preclinical AD affects driving cessation. Read & Research Alzheimer’s More

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The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1–42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer’s disease dementia (ADD; Read & Research Alzheimer’s More

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The stereotypical progression of Alzheimer’s disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non–cell autonomous) Read & Research Alzheimer’s More

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Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. Read & Research Alzheimer’s More

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Mitochondrial genetics are an important but largely neglected area of research in Alzheimer’s disease. A major impediment is the lack of data sets. Read & Research Alzheimer’s More

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Characterizing progression in Alzheimer’s disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free survival in patients with mild cognitive impairment. Read & Research Alzheimer’s More

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Updated American Academy of Neurology guidelines say that regular exercise may improve memory and thinking in people with mild cognitive impairment. Read & Research Alzheimer’s More

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A type 2 diabetes drug that activates three growth factor receptors achieved significant reversal of memory loss in a mouse model of Alzheimer’s disease. Read & Research Alzheimer’s More

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Editorial Board"> Editorial Board

Posted December 29, 2017 By

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Investigators from 26 countries met in Varna, Bulgaria, October 19–20, 2017, at the second in a series of Alzheimer’s Association International Conference® satellite symposia. Researchers discussed new pathways in Alzheimer’s disease (AD) and dementia research, with a particular focus on new therapeutic opportunities. The goals of the meeting were three-fold: Read & Research Alzheimer’s More

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AF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. Read & Research Alzheimer’s More

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Cognitive decline is a distressing experience, but there may be an easy way of keeping your brain healthy. Just take a moderately long walk every day. Read & Research Alzheimer’s More

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Genetic associations for endophenotypes of Alzheimer’s disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated. Read & Research Alzheimer’s More

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Blueberry vinegar could benefit people with dementia, say researchers, after finding that the fermented product improved memory in mice with amnesia. Read & Research Alzheimer’s More

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A new study has suggested that uncoupling between slow waves and spindles in non-REM sleep may be the cause of overnight forgetting in older brains. Read & Research Alzheimer’s More

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The aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites. Read & Research Alzheimer’s More

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Cross-sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single positron emission tomography study can provide both functional Read & Research Alzheimer’s More

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Ten benefits of shilajit"> Ten benefits of shilajit

Posted December 16, 2017 By

Shilajit, also called mineral pitch, is the result of a long process of breaking down plant matter and minerals. Learn about the potential health benefits. Read & Research Alzheimer’s More

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Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration. Read & Research Alzheimer’s More

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Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer’s disease (AD) share many overlapping pathologies and possible clinical links. Read & Research Alzheimer’s More

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An animal model of late-onset Alzheimer’s disease is needed to research what causes degeneration in the absence of dominant genetic insults and why the association cortex is particularly vulnerable to degeneration. Read & Research Alzheimer’s More

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A diet supplemented with canola oil worsened memory and led to weight gain in mouse models of Alzheimer’s disease, researchers report. Read & Research Alzheimer’s More

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Researchers have shown that hyperbaric oxygen therapy alleviates some physical and behavioral symptoms of Alzheimer’s in a mouse model of the disease. Read & Research Alzheimer’s More

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We forecast the prevalence of preclinical and clinical Alzheimer’s disease (AD) and evaluated potential impacts of primary and secondary preventions in the United States. Read & Research Alzheimer’s More

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Scientists have designed a molecule that can interfere with the production of the APOE protein. Mouse tests reveal that the compound prevents brain damage. Read & Research Alzheimer’s More

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A global study of more than 1 million people reveals how obesity in midlife and being underweight near onset are both linked to raised risk of dementia. Read & Research Alzheimer’s More

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According to a recent review of the evidence, holy matrimony might benefit your neurological health as you age. Marriage, it seems, reduces dementia risk. Read & Research Alzheimer’s More

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