Alzheimer apolipoprotein E (APOE) ε4,4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to “coordinated lysosomal expression and regulation” (CLEAR) DNA motifs. Read & Research Alzheimer’s More

Be the first to comment
            

A new study examines whether the personality of those affected by dementia or mild cognitive impairment starts to change before the onset of the disease. Read & Research Alzheimer’s More

Be the first to comment
            

To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer’s Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). Read & Research Alzheimer’s More

Be the first to comment
            

The Alzheimer’s Association International Conference® 2017 (AAIC®) was another record-shattering event in the field of Alzheimer’s and dementia education, research and therapy development. Held in London, United Kingdom, July 15–20, 2017, it brought together nearly 6000 attendees from 70 countries with their unique perspectives—as researchers, clinicians, administrators, and caregivers—to this Read & Research Alzheimer’s More

Be the first to comment
            

We examined whether obesity at ages 50, 60, and 70 years is associated with subsequent dementia. Changes in body mass index (BMI) for more than 28 years before dementia diagnosis were compared with changes in BMI in those free of dementia. Read & Research Alzheimer’s More

Be the first to comment
            

There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. Read & Research Alzheimer’s More

Be the first to comment
            

A recently published study investigates the link between both high and low magnesium serum levels and the risk of developing dementia. Read & Research Alzheimer’s More

Be the first to comment
            

The ApoE gene may have a more influential role than first thought; it may amplify the damage done by the tau protein, causing neurodegeneration. Read & Research Alzheimer’s More

Be the first to comment
            

Across the globe, many national public health strategic plans articulate an aspiration to improve the quality of care for individuals with chronic brain disorders that affect memory, movement, and mood. Although few would argue against this intent, the development and delivery of coordinated implementation plans that balances the perspective of Read & Research Alzheimer’s More

Be the first to comment
            

The Centers for Medicare and Medicaid Services (CMS) has proposed adding new billing codes for telehealth services to benefits in the 2018 Medicare Physician Fee Schedule. Through video conferencing, patient portals, remote vital sign monitoring, and other telecommunications technology, telemedicine allows providers to interact remotely with patients in their home. Read & Research Alzheimer’s More

Be the first to comment
            

A new study challenges the traditional understanding of Alzheimer’s disease, as scientists point to a new gene that may be responsible for the illness. Read & Research Alzheimer’s More

Be the first to comment
            

There is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer’s disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit—long sought Read & Research Alzheimer’s More

Be the first to comment
            

Profiling the spatial-temporal expression pattern and characterizing the regulatory networks of brain tissues are vital for understanding the pathophysiology of Alzheimer’s disease (AD). Read & Research Alzheimer’s More

Be the first to comment
            

Neurodegenerative diseases such as Alzheimer’s disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels Read & Research Alzheimer’s More

Be the first to comment
            

Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. Read & Research Alzheimer’s More

Be the first to comment
            

A new advisory from the American Heart Association outlines seven steps for preventing age-related cognitive decline and vascular dementia. Read & Research Alzheimer’s More

Be the first to comment
            

Medicare beneficiaries with Alzheimer’s disease and related dementias (ADRDs) may have more potentially avoidable hospitalizations and readmissions than people without dementia. These hospitalizations may be indicative of access barriers, problems in continuity of care, inefficient resource use, and poor patient outcomes. Read & Research Alzheimer’s More

Be the first to comment
            

Subscriber Information"> Subscriber Information

Posted September 1, 2017 By

Read & Research Alzheimer’s More

Be the first to comment
            

Editorial Board"> Editorial Board

Posted September 1, 2017 By

Read & Research Alzheimer’s More

Be the first to comment
            

Uncovering the molecular mechanism behind a rare genetic risk factor of Alzheimer’s disease points to a new therapeutic target. Read & Research Alzheimer’s More

Be the first to comment
            

Whole-cell patch clamp electrophysiology, or whole-cell recording (WCR), is the gold-standard technique for studying the behaviour of brain cells called neurons under different brain states such as… Read & Research Alzheimer’s More

Be the first to comment
            

A new study shows how a series of events involving immune cells, amyloid beta, and tau could be the start of Alzheimer’s and names targets for stopping it. Read & Research Alzheimer’s More

Be the first to comment
            

In mice, microglia may persist the entire lifespan of the animal. The cells’ lifetime may be linked to their role in immune memory and neurodegenerative diseases. Read & Research Alzheimer’s More

Be the first to comment
            

The brain begins to decline with age. We examine what happens to the brain over time and whether the rate of decline can be slowed or even prevented. Read & Research Alzheimer’s More

Be the first to comment
            

Researchers have found that both strength-endurance training and dancing increased hippocampal volume in the brain, but the latter had the greatest impact. Read & Research Alzheimer’s More

Be the first to comment
            

A new meta-analysis suggests that women and men face the same Alzheimer’s genetic risk factor, but women are more susceptible between ages 65 and 75. Read & Research Alzheimer’s More

Be the first to comment
            

Researchers have created an algorithm that could predict the risk of Alzheimer’s in patients with mild cognitive impairment 2 years before symptoms arise. Read & Research Alzheimer’s More

Be the first to comment
            

A new study finds that insufficient REM sleep – the sleep phase wherein we do most of our dreaming – is strongly linked with an increased risk of dementia. Read & Research Alzheimer’s More

Be the first to comment
            

A study of more than 800,000 people in Denmark finds that those exposed to higher levels of lithium in drinking water were at lower risk of dementia. Read & Research Alzheimer’s More

Be the first to comment
            

Researchers reveal how a novel imaging technique could diagnose Alzheimer’s disease by detecting beta-amyloid plaques in the retinas of patients. Read & Research Alzheimer’s More

Be the first to comment