New research finds that nilvadipine, a drug doctors commonly use to treat high blood pressure, increases the blood flow to the brain’s hippocampus. Read & Research Alzheimer’s More

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Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of Read & Research Alzheimer’s More

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Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that Read & Research Alzheimer’s More

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According to the largest research of its kind yet, atrial fibrillation may raise the risk of dementia even in people who did not experience a stroke. Read & Research Alzheimer’s More

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A study of adults aged 50 and over found that decline in memory and thinking was faster after a heart attack or angina, but not before. Read & Research Alzheimer’s More

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A study of adults aged 50 and over found that decline in memory and thinking was faster after a heart attack or angina, but not before. Read & Research Alzheimer’s More

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Little is known about the longitudinal association between napping and cognitive impairment in older adults. Read & Research Alzheimer’s More

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Scientists find a key difference between Alzheimer’s and frontotemporal dementia: the latter affects a person’s ‘moral emotions’ while the former does not. Read & Research Alzheimer’s More

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New research asks to what extent, if any, a person’s level of education is linked to the presence of Alzheimer’s disease and the rate of cognitive decline. Read & Research Alzheimer’s More

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Although Alzheimer’s disease (AD) is frequently cited as the most common type of dementia, the relative contributions of vascular and neurodegenerative pathology to clinical dementia have been actually obscure. The systematic review of studies reporting clinicopathologic data of dementia cases sheds important light on this issue [1]. Ten reports were Read & Research Alzheimer’s More

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It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer’s disease (AD) dementia. Read & Research Alzheimer’s More

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Mouse study shows that focused ultrasound and injected microbubbles can help curb early Parkinson’s disease by allowing drugs to access the brain. Read & Research Alzheimer’s More

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Researchers from Japan have tested a new gene therapy against Parkinson’s disease using mouse models. Their results suggest that the approach is effective. Read & Research Alzheimer’s More

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Age- and sex-stratified incidence rates of uncommon dementia subtypes are imprecise and scarce. Read & Research Alzheimer’s More

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A large study analyzing the medical data of thousands of people suggests that dementia incidence is lower among those who take blood pressure medication. Read & Research Alzheimer’s More

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Neuroimaging biomarkers are important for early diagnosis of Alzheimer’s disease, and comparing multimodality neuroimaging to autopsy data is essential. Read & Research Alzheimer’s More

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A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer’s disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer’s Disease [PREVENT-AD]). Read & Research Alzheimer’s More

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New research suggests that using a virtual reality simulator could be more effective at detecting Alzheimer’s disease than standard tests. Read & Research Alzheimer’s More

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To report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait. Read & Research Alzheimer’s More

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We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer’s disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Read & Research Alzheimer’s More

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A study using human biological samples and mouse models has found what can make viruses more dangerous and how some could facilitate Alzheimer’s. Read & Research Alzheimer’s More

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A new study connects high blood levels of ‘bad’ cholesterol with the presence of early-onset Alzheimer’s. The link, the authors suggest, could be causal. Read & Research Alzheimer’s More

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We evaluated whether incident mild cognitive impairment (MCI) subtypes could be empirically derived in the Mayo Clinic Study of Aging. Read & Research Alzheimer’s More

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A brain study in rats that explored different environments reveals that the anterior cingulate cortex drives the hippocampus in long-term memory recall. Read & Research Alzheimer’s More

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New research finds that some Alzheimer’s-related biomarkers in the brain change as early as 34 years before the onset of visible symptoms. Read & Research Alzheimer’s More

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Blood-based biomarkers of pathophysiological brain amyloid β (Aβ) accumulation, particularly for preclinical target and large-scale interventions, are warranted to effectively enrich Alzheimer’s disease clinical trials and management. Read & Research Alzheimer’s More

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The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer’s disease are poorly understood. Read & Research Alzheimer’s More

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The WHO have recently released a new set of guidelines around strategies for dementia prevention, in which they evaluate potential interventions. Read & Research Alzheimer’s More

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According to a recent study, virtual reality might provide a useful tool for treating dementia. Among other things, it may help improve memory. Read & Research Alzheimer’s More

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A drug that tackles toxic protein buildup in Alzheimer’s disease in a novel way has passed phase 1 of clinical trials, which tests safety in humans. Read & Research Alzheimer’s More

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