Archive for May, 2013

In some neurodegenerative diseases, and specifically in a devastating inherited condition called spinocerebellar ataxia 1 (SCA1), the answer may not be an “all-or-nothing,” said a collaboration of researchers from Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and the University of Minnesota Read & Research Alzheimer’s More

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Researchers at Lund University in Sweden have identified the molecular mechanism behind the transformation of one of the components in Alzheimer’s disease. They identified the crucial step leading to formations that kill brain cells. Alzheimer’s disease is associated with memory a loss and personality changes… Read & Research Alzheimer’s More

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Blood offers promise as a way to detect Alzheimer’s disease at its earliest onset, Mayo Clinic researchers say. They envision a test that would detect distinct metabolic signatures in blood plasma that are synonymous with the disease – years before patients begin showing cognitive decline. Their study was recently published Read & Research Alzheimer’s More

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For several years, the pharmaceutical industry has tried to develop drugs that target a specific neurotransmitter receptor in the brain, the NMDA receptor. This receptor is present on almost every neuron in the human brain and is involved in learning and memory… Read & Research Alzheimer’s More

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An Alzheimer’s disease protein controls the speed at which materials move through brain cells, and defects could lead to deadly pileups of the kind seen in neurodegenerative disease, a new publication finds Imagine if you could open up your brain and look inside… Read & Research Alzheimer’s More

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Scientists at the University of Liverpool and Callaghan Innovation in New Zealand have developed a new chemical approach to help harness the natural ability of complex sugars to treat Alzheimer’s disease. The team used a new chemical method to produce a library of sugars, called heparan sulphates, which are known Read & Research Alzheimer’s More

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In the search for medication against Alzheimer’s disease, scientists have focused – among other factors – on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the known plaques in the brains of Alzheimer’s patients. Starting point for the formation of Read & Research Alzheimer’s More

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Approximately a year ago, the leading journal Science published an article about bexarotene as a potential Alzheimer’s drug. A significant breakthrough and an important starting point for further Alzheimer’s research… Read & Research Alzheimer’s More

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Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of – or warding off – the effects of Alzheimer’s disease. That is, according to Roshni George and Donald Graves, scientists Read & Research Alzheimer’s More

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Anti-cancer drug bexarotene (Tagretin), which had extremely promising results in reversing Alzheimer’s disease symptoms in mice last year, was found not to be as promising in later trials, according to articles published in the journal Science. In other words, scientists have not able to fully replicate the original findings… Read & Research Alzheimer’s More

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Teams of highly respected Alzheimer’s researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science. Those results, presented online Feb… Read & Research Alzheimer’s More

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An anti-cancer drug about to be tested in a clinical trial by a biomedical company in Ohio as a possible treatment for Alzheimer’s disease has failed to work with the same type of brain plaques that plague Alzheimer’s patients, according to results of a study by University of Florida researchers. Read & Research Alzheimer’s More

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An anti-cancer drug may reverse memory problems in an Alzheimer’s Disease mouse model, according to new research carried out at the University of Pittsburgh Graduate School of Public Health. The study, published in the journal Science, examined previously published outcomes on the drug bexarotene – which is approved by the Read & Research Alzheimer’s More

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Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer’s Disease in mice. The drugs, known as “TSPO ligands,” are currently used for certain types of neuroimaging… Read & Research Alzheimer’s More

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In a new breakthrough to find the cause of Alzheimer’s disease, scientists have pinpointed a molecule that appears to trigger a chain reaction of protein malfunction that eventually clogs up and kills brain cells… Read & Research Alzheimer’s More

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Brain power in older people at risk for vascular dementia seems to improve more from a Mediterranean diet with added mixed nuts or extra virgin olive oil than from a low-fat diet that is typically followed to prevent heart attack and stroke, according to the results of a Spanish Read & Research Alzheimer’s More

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Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain… Read & Research Alzheimer’s More

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A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer’s disease. Their findings were recently reported in the online version Read & Research Alzheimer’s More

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Alzheimer’s disease is the most common neurodegenerative disorder, affecting more than five million Americans, but currently there is no way to prevent, delay or stop its progression. A study published online by the Cell Press journal Neuron shows that a gene called CD33 contributes to Alzheimer’s disease by inhibiting the Read & Research Alzheimer’s More

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Most information about the cause of Alzheimer’s disease is based on studies from animal models. Now, a study published by Cell Press in the journal Cell examines the brain tissue of deceased human patients and sheds light on dysfunctions in molecular networks in the brain that are at the root Read & Research Alzheimer’s More

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Scientists from the Icahn School of Medicine at Mount Sinai, in collaboration with researchers from Icelandic Heart Association, Sage Bionetworks, and other institutions, have discovered that a network of genes involved in the inflammatory response in the brain is a crucial mechanism driving Late Onset Alzheimer’s Disease (LOAD)… Read & Research Alzheimer’s More

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The Mediterranean diet appears to be associated with preserving memory and cognitive abilities, researchers from the University of Alabama at Birmingham (UAB), USA, and the University of Athens, Greece, reported in the journal Neurology (April 30th, 2013 issue)… Read & Research Alzheimer’s More

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A potential new treatment strategy for patients with Charcot-Marie-Tooth disease is on the horizon, thanks to research by neuroscientists now at the University at Buffalo’s Hunter James Kelly Research Institute and their colleagues in Italy and England… Read & Research Alzheimer’s More

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Australian scientists are much closer to developing a screening test for the early detection of Alzheimer’s disease, the leading cause of dementia. A quarter of a million Australians currently suffer from dementia and given our ageing population, this is predicted to increase to one million by 2050… Read & Research Alzheimer’s More

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Late-life depression is associated with an increased risk for all-cause dementia, Alzheimer’s disease and, most predominantly, vascular dementia, according to the results of a new meta-analysis published today in the British Journal of Psychiatry… Read & Research Alzheimer’s More

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Leaving the house in the morning may seem simple, but with every move we make, our brains are working feverishly to create maps of the outside world that allow us to navigate and to remember where we are. Take one step out the front door, and an individual brain cell Read & Research Alzheimer’s More

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JAMA Neurology Study Highlights A study by Stephanie Cosentino, Ph.D., of Columbia University, New York, and colleagues examines the relationship between families with exceptional longevity and cognitive impairment consistent with Alzheimer disease… Read & Research Alzheimer’s More

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Scientists’ picture of how a gene strongly linked to Alzheimer’s disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found. People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer’s disease Read & Research Alzheimer’s More

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Some memory problems common to older adults may stem from an inability to segment daily life into discrete experiences, according to a new study published in Psychological Science, a journal of the Association for Psychological Science… Read & Research Alzheimer’s More

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Scientists at the Virginia Tech Carilion Research Institute have discovered how the predominant class of Alzheimer’s pharmaceuticals might sharpen the brain’s performance One factor even more important than the size of a television screen is the quality of the signal it displays… Read & Research Alzheimer’s More

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