β-Site amyloid precursor protein–cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau

By Amalia Tsolakidou, Panagiotis Alexopoulos, Liang-Hao Guo, Timo Grimmer, Christine Westerteicher, Martina Kratzer, Meizi Jiang, Hideaki Bujo, Francesco Roselli, Maria Rosaria Leante, Paolo Livrea, Alexander Kurz, Robert Perneczky Abstract: Background: β-Site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer’s disease (AD).Methods: The present study explored the correlation between BACE1 activity and cerebrospinal fluid (CSF) markers Read & Research Alzheimer’s More

Leave a Reply