Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimer's disease

By Henrik Zetterberg, Kaj Blennow Abstract: Certain preparations of Alzheimer-associated amyloid beta (Aβ) exhibit rapid (within minutes) synaptotoxicity when applied to hippocampal slices or neuronal cell cultures, or when injected into the central nervous system of rodents. In addition, it is well known that some elderly people have brain amyloidosis without showing signs of cognitive Read & Research Alzheimer’s More

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