Impact of molecular imaging on the diagnostic process in a memory clinic

By Rik Ossenkoppele, Niels D. Prins, Yolande A.L. Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Sofie F. Adriaanse, Albert D. Windhorst, Ron L.H. Handels, Claire A.G. Wolfs, Pauline Aalten, Frans R.J. Verhey, Marcel M. Verbeek, Mark A. van Buchem, Otto S. Hoekstra, Adriaan A. Lammertsma, Philip Scheltens, Bart N.M. van Berckel Abstract: Background: [11C]Pittsburgh compound B ([11C]PIB) and [18F]-2-fluoro-2-deoxy-D-glucose ([18F]FDG) PET measure fibrillar amyloid-β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.Methods: One hundred fifty-four patients underwent paired dynamic [11C]PIB and static [18F]FDG PET scans shortly after completing Read & Research Alzheimer’s More

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