The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case–control cohorts

By Letizia Polito, Patrick G. Kehoe, Annalisa Davin, Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Pierluigi Quadri, Ugo Lucca, Mauro Tettamanti, Francesca Clerici, Silvia Bagnoli, Daniela Galimberti, Benedetta Nacmias, Sandro Sorbi, Antonio Guaita, Elio Scarpini, Claudio Mariani, Gianluigi Forloni, Diego Albani Abstract: Background: Human sirtuins are a current hotspot for research in neurodegenerative disorders, including Alzheimer’s disease (AD). This study investigated whether genetic variants in two members of the sirtuin family, SIRT2 and SIRT3, affected AD susceptibility.Methods: A genetic case–control study was performed, comprising 534 probable AD cases and 638 nondemented control Read & Research Alzheimer’s More

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