Archive for July, 2013

People with poor oral hygiene or gum disease may be at a greater risk of developing Alzheimer’s disease, a new study led by The University of Central Lancashire (UCLan) School of Medicine and Dentistry suggests… Read & Research Alzheimer’s More

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A study has found that people with poor oral hygiene or gum disease could be at higher risk of developing Alzheimer’s compared with those who have healthy teeth. Researchers from the University of Central Lancashire (UCLan) in the UK, discovered the presence of a bacterium called Porphyromonas gingivalis in the Read & Research Alzheimer’s More

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Higher variability in visit-to-visit blood pressure readings, independent of average blood pressure, could be related to impaired cognitive function in old age in those already at high risk of cardiovascular disease, suggests a paper published on bmj.com. There is increasing evidence that vascular factors contribute in development and progression of Read & Research Alzheimer’s More

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Glucose intolerance or insulin resistance do not appear to be associated with pathological features of Alzheimer disease (AD) or detection of the accumulation of the brain protein β-amyloid (”β), according to a report published by JAMA Neurology, a JAMA Network publication… Read & Research Alzheimer’s More

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Brain cells talk to each other in a variety of tones. Sometimes they speak loudly but other times struggle to be heard. For many years scientists have asked why and how brain cells change tones so frequently. National Institutes of Health researchers showed that brief bursts of chemical energy coming Read & Research Alzheimer’s More

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A research team from the School of Basic Medical Sciences, Beijing University of Chinese Medicine reports that Radix Achyranthis Bidentatae can inhibit advanced glycation end product formation, reduce their levels in the frontal cortex, and improve learning and memory capabilities in ovariectomized rats… Read & Research Alzheimer’s More

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Researchers in Germany have identified a new blood test that may in future provide much earlier diagnosis of Alzheimer’s disease and other degenerative disorders. The team, from Saarland University and Siemens Healthcare, describe their test in the open access journal Genome Biology… Read & Research Alzheimer’s More

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UCLA chemists and molecular biologists have for the first time used a “structure-based” approach to drug design to identify compounds with the potential to delay or treat Alzheimer’s disease, and possibly Parkinson’s, Lou Gehrig’s disease and other degenerative disorders… Read & Research Alzheimer’s More

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An international team of researchers has found that over 90 percent of dementia cases in China go undetected, with a high level of undiagnosed dementia in rural areas… Read & Research Alzheimer’s More

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Scientists from The University of Manchester have used stem cell gene therapy to treat a fatal genetic brain disease in mice for the first time. The method was used to treat Sanfilippo – a fatal inherited condition which causes progressive dementia in children – but could also benefit several neurological, Read & Research Alzheimer’s More

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Key molecular pathways that ultimately lead to late-onset Alzheimer’s disease, the most common form of the disorder, have been identified by researchers at Columbia University Medical Center (CUMC). The study, which used a combination of systems biology and cell biology tools, presents a new approach to Alzheimer’s disease research and Read & Research Alzheimer’s More

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A class of drug used to lower blood pressure could potentially slow the rate of cognitive decline in dementia and even boost brain power, according to a study published by BMJ Open. Researchers from Ireland analyzed the cognitive decline and brain power of 361 patients with an average age of Read & Research Alzheimer’s More

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Positive results from three new studies on human-animal interaction (HAI) were presented at the triennial conference of the International Association of Human-Animal Interaction Organizations (IAHAIO) in Chicago, IL… Read & Research Alzheimer’s More

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Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation… Read & Research Alzheimer’s More

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The molecular pathway linking a genetic variant to the common, non-familial form of Alzheimer’s disease is revealed in Nature this week. The study boosts our knowledge of the pathology of this neurodegenerative disease, and hints at new directions for therapy. People who carry a particular gene allele APOE4 can be Read & Research Alzheimer’s More

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Chinese herbal medicine, which has been used for thousands of years in China, has long been considered an effective treatment for vascular dementia. There are already meta-analyses of the effects of herbal extracts (ginkgo biloba and huperzine A) on vascular dementia… Read & Research Alzheimer’s More

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Research from the Regenstrief Institute and the Indiana University Center for Aging Research has found that many family caregivers of older adults with dementia are willing to consider stopping cancer screening of the elderly individual; they are also relieved when the older adult’s physician brings it up… Read & Research Alzheimer’s More

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Computerized cognitive testing is increasingly playing a key role in therapy development for dementia and Alzheimer’s disease. At the Alzheimer’s Association International Conference, Keith Wesnes Ph.D., Practice Leader of Bracket and founder of the CDR System™, discussed new data for novel therapies at two poster presentations… Read & Research Alzheimer’s More

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Rhode Island Hospital researchers have found that multiple factors contribute to the burden felt by caregivers of people living with Alzheimer’s and other forms of dementia. These factors include the direct impact of providing care upon the caregivers’ lives, guilt, and frustration or embarrassment. The study is published online in Read & Research Alzheimer’s More

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Researchers say there are certain lifestyle measures we can take to reduce our risk of developing Alzheimer’s disease and dementia, including being physically active, eating a healthy and balanced diet, maintaining good cardiovascular health, and exercising the brain… Read & Research Alzheimer’s More

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People with Alzheimer’s disease are able to manage their everyday activities longer and they suffer from less psychological and behavioural symptoms if the diagnosis is made and treatment begun at a very early phase of the disease, indicates a recent study conducted at the University of Eastern Finland. The study Read & Research Alzheimer’s More

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People with impaired glucose tolerance – the precursor to Type 2 diabetes – often show impaired cognitive function that may be alleviated through a diet designed specifically for their condition, according to a panel discussion at the 2013 Institute of Food Technologists (IFT) Annual Meeting & Expo®… Read & Research Alzheimer’s More

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People who found out they carried an uncommon genetic risk for Alzheimer’s disease did not experience more anxiety, depression or distress than non-carriers, and were more active in efforts to reduce their risk of Alzheimer’s disease – by exercising, eating a healthy diet and taking recommended vitamins and medications – Read & Research Alzheimer’s More

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The trajectory of amyloid plaque buildup – clumps of abnormal proteins in the brain linked to Alzheimer’s disease – may serve as a more powerful biomarker for early detection of cognitive decline rather than using the total amount to gauge risk, researchers from Penn Medicine’s Department of Radiology suggest in Read & Research Alzheimer’s More

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Microglial cells play an important role in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors, including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, nitric oxide and reactive oxygen species… Read & Research Alzheimer’s More

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Weill Cornell Medical College neurologist Dr. Norman Relkin reported new findings from the Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in mild to moderate Alzheimer’s disease at the Alzheimer’s Association International Conference (AAIC) in Boston, Mass… Read & Research Alzheimer’s More

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A very large study of self-employed people living in France finds those who retired later had a lower risk of being diagnosed with dementia, in line with the idea that you either “use it or lose it.” Carole Dufouil of the Bordeaux School of Public Health, and colleagues, found Read & Research Alzheimer’s More

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The proportion of people with dementia in the UK has fallen, according to new estimates from the first ever study to show how dementia prevalence has changed in the UK population over time, published in The Lancet… Read & Research Alzheimer’s More

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A study by researchers at Neuroscience Research Australia (NeuRA) is the first to demonstrate that patients with frontotemporal dementia (FTD) lose the emotional content/colour of their memories. These findings explain why FTD patients may not vividly remember an emotionally charged event like a wedding or funeral… Read & Research Alzheimer’s More

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When Georgetown University neurologist R. Scott Turner, MD, PhD, began enrolling people with mild to moderate Alzheimer’s disease into a nationwide study last year, he expected to find only a handful of participants with undiagnosed glucose intolerance, as all the patients were already under a doctor’s care and those with Read & Research Alzheimer’s More

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