Archive for August, 2013

‘Where’ and ‘how’ memories are encoded in a nervous system is one of the most challenging questions in biological research. The formation and recall of associative memories is essential for an independent life. The hippocampus has long been considered a centre in the brain for the long-term storage of spatial Read & Research Alzheimer’s More

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A team of Columbia University Medical Center (CUMC) researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible… Read & Research Alzheimer’s More

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Scientists say they have discovered a protein deficiency in the brain that is a major cause of age-related memory loss, according to a study published online in the journal Science Translational Medicine… Read & Research Alzheimer’s More

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Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according to a study by Mahdi Ghani, Ph.D., of the University of Toronto, Ontario, Canada, and colleagues… Read & Research Alzheimer’s More

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Patients with a diagnosis of dementia have approximately three times the rate of diagnosis of urinary incontinence, and more than four times the rate of fecal incontinence, compared with those without a diagnosis of dementia, according to a study in this week’s issue of PLOS Medicine by Robert Grant (Kingston Read & Research Alzheimer’s More

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The ability of different regions of the brain to communicate gradually breaks down with aging and in Alzheimer’s disease, but there are key differences between these two processes. Some of these differences are reported in a study that compared neural networks, signaling efficiency, and disruptions in connectivity in the brains Read & Research Alzheimer’s More

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The ability to draw spontaneously as well as from memory may be preserved in the brains of artists long after the deleterious effects of vascular dementia have diminished their capacity to complete simple, everyday tasks, according to a new study by physicians at St. Michael’s Hospital… Read & Research Alzheimer’s More

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Alzheimer’s disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there’s no stopping that. Most researchers believe the disease is caused by one of two proteins, one called tau, the other beta-amyloid. As we age, most Read & Research Alzheimer’s More

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A leading group of Alzheimer’s researchers contends that, as biomarkers to detect signals of the disease improve at providing clinically meaningful information, researchers will need guidance on how to constructively disclose test results and track how disclosure impacts both patients and the data collected in research studies… Read & Research Alzheimer’s More

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Eating too much red meat, which raises brain levels of iron, may heighten the risk of developing Alzheimer’s disease, researchers from the Semel Institute for Neuroscience and Human Behavior at UCLA reported in the Journal of Alzheimer’s Disease. As background information, the authors explained that iron can accelerate the damaging Read & Research Alzheimer’s More

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New research suggests copper that enters the body at levels encountered in the average modern diet may be leading, eventually, to Alzheimer’s disease – by reducing the body’s ability to clear away toxic proteins in the brain, and also by encouraging the clumping of those proteins. Copper is an Read & Research Alzheimer’s More

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Researchers at Kaiser Permanente and the University Medical Centre Utrecht in the Netherlands have created the first risk score that predicts the 10-year individualized dementia risk for patients with type 2 diabetes, as reported in the inaugural issue of Lancet Diabetes & Endocrinology… Read & Research Alzheimer’s More

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Scientists have created a simple scoring system that will allow clinicians to predict whether older people with type 2 diabetes are at risk of developing dementia, according to a study published in The Lancet Diabetes and Endocrinology… Read & Research Alzheimer’s More

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To stop the progression of Alzheimer’s disease in the early stage, it is necessary to identify new therapeutic targets. Prof… Read & Research Alzheimer’s More

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Decision-making by a surrogate for a family member who is unable to make medical decisions is more complicated than decision-making by patients themselves, according to a study from the Regenstrief Institute, Indiana University Center for Aging Research and the Charles Warren Fairbanks Center for Medical Ethics of Indiana University Health… Read & Research Alzheimer’s More

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John Hopkins biophysicists have identified a “rocking” motion in a protein ensemble, a “back and forth” movement critical in the normal functioning of brain signaling molecules. The work could lead to advancements in neurological treatments… Read & Research Alzheimer’s More

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A study just published reported the identification of what may be the earliest known biomarker associated with the risk of developing Alzheimer’s disease (AD). The results suggest that this novel potential biomarker is present in cerebral spinal fluid (CSF) at least a decade before signs of dementia manifest… Read & Research Alzheimer’s More

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What if we could pinpoint a hereditary cause for Alzheimer’s, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer’s Read & Research Alzheimer’s More

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The steady accumulation of a protein in healthy, aging brains may explain seniors’ vulnerability to neurodegenerative disorders, a new study by researchers at the Stanford University School of Medicine reports. The study’s unexpected findings could fundamentally change the way scientists think about neurodegenerative disease… Read & Research Alzheimer’s More

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Depression in patients with type 2 diabetes was associated with greater cognitive decline in a study of almost 3,000 individuals who participated in a clinical trial, according to a report published by JAMA Psychiatry, a JAMA Network publication. Depression and diabetes are among the most common illnesses in Read & Research Alzheimer’s More

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A Swedish study involving military men identifies nine risk factors, many of which may be preventable for adolescents, that are associated with young-onset dementia – dementia diagnosed before the age of 65. The study, which was published online by JAMA Internal Medicine, followed 488,484 Swedish men who enlisted in mandatory Read & Research Alzheimer’s More

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Twelve national dementia clinical practice guidelines included only half of 31 ethical issues the authors had identified as important in patient care, finds a study by Daniel Strech, of Hannover Medical School, Hannover, Germany, and colleagues, published in this week’s issue of PLOS Medicine… Read & Research Alzheimer’s More

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A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer’s Disease. Their findings, which appear in the journal Nature Neuroscience, also point to a potential therapeutic intervention for alleviating memory-related disorders… Read & Research Alzheimer’s More

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3-N-butylphthalide, a green botanical medicine, is a successfully synthesized and stable chemical drug used for the treatment of ischemic stroke that has independent intellectual property rights in China. The first L-isomer, originally extracted from celery seed, was artificially synthesized from racemic acid, also known as butylphthalide… Read & Research Alzheimer’s More

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Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis… Read & Research Alzheimer’s More

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Scientists at Sanford-Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging… Read & Research Alzheimer’s More

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Researchers have discovered that those with a high blood sugar level, even if they do not have diabetes, may have an increased risk of developing dementia compared with those who have a normal blood sugar level. The study, published in the New England Journal of Medicine, analyzed 2,067 participants without Read & Research Alzheimer’s More

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Johns Hopkins biophysicists have discovered that full activation of a protein ensemble essential for communication between nerve cells in the brain and spinal cord requires a lot of organized back-and-forth motion of some of the ensemble’s segments… Read & Research Alzheimer’s More

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Though one might think the brains of people who develop Alzheimer’s disease (AD) possess building blocks of the disease absent in healthy brains, for most sufferers, this is not true… Read & Research Alzheimer’s More

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A joint Group Health – University of Washington (UW) study in the New England Journal of Medicine has found that higher blood sugar levels are associated with higher dementia risk, even among people who do not have diabetes… Read & Research Alzheimer’s More

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