Archive for September, 2013

An Argentine research team has found evidence of a possible trigger factor for the onset of Alzheimer’s disease: stress. Dr Edgardo Reich (Buenos Aires) presented a study on the subject at the XXI World Congress of Neurology in Vienna. 118 patients with diagnosis of Alzheimer’s disease were examined, their average Read & Research Alzheimer’s More

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Alzheimer’s disease is characterized by the accumulation of particular toxic proteins in the brain that are believed to underlie the cognitive decline in patients. A new study conducted in mice suggests that newly identified antibody treatments can prevent the accumulation of one of these of these toxic components, called tau Read & Research Alzheimer’s More

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As we get older, there is no doubt that our brains become slower. But new research suggests that life experience may make up for cognitive decline in old age… Read & Research Alzheimer’s More

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New Danish/Italian research shows how medicine for the brain can be absorbed through the nose. This paves the way to more effective treatment of neurological diseases like Alzheimer’s and tumors in the brain. A big challenge in medical science is to get medicine into the brain when treating patients with Read & Research Alzheimer’s More

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There have been many studies advocating how omega-3 fatty acids can benefit our health. But a new study suggests that high levels of omega-3 are of no benefit to cognitive decline in older women. Omega-3 polyunsaturated fatty acids (PUFAs) are types of fats commonly found in plant and marine life… Read & Research Alzheimer’s More

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Patients suffering from early symptoms of Alzheimer’s disease who were diagnosed sooner than usual using a brain imaging test received Alzheimer-specific medications earlier than those who did not have the brain imaging results available to their doctors or themselves… Read & Research Alzheimer’s More

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A new study published in the September issue of the Journal of Alzheimer’s Disease reports that even a single mild explosion can cause changes in the brain that have similarities to those found in diseases like Alzheimer’s disease and chronic traumatic encephalopathy. Flying debris or getting thrown against other objects Read & Research Alzheimer’s More

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Massachusetts General Hospital (MGH) researchers have identified and validated two rare gene mutations that appear to cause the common form of Alzheimer’s disease (AD) that strikes after the age of 60… Read & Research Alzheimer’s More

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Health care systems need to manage chronic pain better in people with dementia and dispel the notion that people with dementia feel less pain, states an editorial in CMAJ (Canadian Medical Association Journal). “Any notion that people with dementia feel pain less should be dismissed,” writes Dr. Ken Flegel, Senior Read & Research Alzheimer’s More

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Scientists of the Charite – Universitatsmedizin Berlin and the German Center for Neurodegenerative Diseases (DZNE) have managed to acquire new insights into the functioning of a region in the brain that normally is involved in spatial orientation, but is damaged by the Alzheimer’s disease. They investigated how nerve signals are Read & Research Alzheimer’s More

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The World Alzheimer Report 2013 ‘Journey of Caring: An analysis of long-term care for dementia’, calls for governments around the world to make dementia a priority by implementing national plans, and by initiating urgent national debates on future arrangements for long-term care… Read & Research Alzheimer’s More

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A class of proteins that controls visual system development in the young brain also appears to affect vulnerability to Alzheimer’s disease in the aging brain. The proteins, which are found in humans and mice, join a limited roster of molecules that scientists are studying in hopes of finding an effective Read & Research Alzheimer’s More

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Scientists at the Stanford University School of Medicine have shown how a protein fragment known as beta-amyloid, strongly implicated in Alzheimer’s disease, begins destroying synapses before it clumps into plaques that lead to nerve cell death… Read & Research Alzheimer’s More

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The loss of estrogens at menopause increases a woman’s risk of dementia and Alzheimer’s disease, yet hormone replacement therapy can cause harmful side effects… Read & Research Alzheimer’s More

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What if doctors could visualize all of the processes that take place in the brain during the development and progression of Alzheimer’s disease? Such a window would provide a powerful aid for diagnosing the condition, monitoring the effectiveness of treatments, and testing new preventive and therapeutic agents… Read & Research Alzheimer’s More

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More than half of all patients with pre-existing dementia will experience delirium while hospitalized. Failing to detect and treat their delirium early leads to a faster decline of both their physical and mental health, according to health researchers… Read & Research Alzheimer’s More

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Demographically, the United States is witnessing two major changes; people are living longer, and more people are divorcing and remarrying. In the first study of its kind, research in Journal of Marriage and Family examines the challenges faced by remarried caregivers. Over 35 million Americans are remarried, with 500,000 adults Read & Research Alzheimer’s More

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A drug commonly used for treating diabetes may reverse symptoms of late-stage Alzheimer’s disease and is now in the process of entering a major clinical trial… Read & Research Alzheimer’s More

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Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found a group of proteins essential to the formation of long-term memories. The study, published online ahead of print on September 12, 2013 by the journal Cell Reports, focuses on a family of proteins called Wnts… Read & Research Alzheimer’s More

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New research has shown that cognitive decline in people with Type 2 Diabetes is likely due to brain atrophy, or shrinkage, that resembles patterns seen in the early stages of Alzheimer’s disease… Read & Research Alzheimer’s More

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Alzheimer’s disease is thought to be caused by the buildup of abnormal, thread-like protein deposits in the brain, but little is known about the molecular structures of these so-called beta-amyloid fibrils… Read & Research Alzheimer’s More

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By Yoshiko Furiya, Miwa Ryo, Makoto Kawahara, Takao Kiriyama, Masami Morikawa, Satoshi Ueno Abstract: Background: Accumulating evidence indicates an association of Alzheimer’s disease (AD) with the metabolic syndrome (MetS), characterized by visceral fat accumulation with insulin resistance and altered secretion of adipocytokines such as adiponectin and leptin. The renin-angiotensin system (RAS) regulates blood pressure and insulin resistance. Recent studies suggest that the RAS Read & Research Alzheimer’s More

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By Rachel Yoon Kyung Chang, Amanda S. Nouwens, Peter R. Dodd, Naomi Etheridge Abstract: Background: Synaptic dysfunction occurs early in Alzheimer’s disease (AD) and is recognized to be a primary pathological target for treatment. Synapse degeneration or dysfunction contributes to clinical signs of dementia through altered neuronal communication; the degree of synaptic loss correlates strongly with cognitive impairment. The molecular mechanisms underlying synaptic Read & Research Alzheimer’s More

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By Emilie Chary, Hélène Amieva, Karine Pérès, Jean-Marc Orgogozo, Jean-François Dartigues, Hélène Jacqmin-Gadda Abstract: Background: Using simple measures of cognition and disability in a prospective community-living cohort of normal elderly persons, the main objectives of our study were to distinguish short- and long-term predictors for dementia according to educational level and to propose a tool for early detection of subjects at high risk Read & Research Alzheimer’s More

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By Yannick Vermeiren, Nathalie Le Bastard, An Van Hemelrijck, Wilhelmus H. Drinkenburg, Sebastiaan Engelborghs, Peter P. De Deyn Abstract: Background: Behavioral and psychological signs and symptoms of dementia (BPSD) are a heterogeneous group of behavioral and psychiatric disturbances occurring in dementia patients of any etiology. Research suggests that altered activities of dopaminergic, serotonergic, (nor)adrenergic, as well as amino acid neurotransmitter systems play a role in the etiopathogenesis of Read & Research Alzheimer’s More

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By Yen Ying Lim, Kathryn A. Ellis, David Ames, David Darby, Karra Harrington, Ralph N. Martins, Colin L. Masters, Christopher Rowe, Greg Savage, Cassandra Szoeke, Victor L. Villemagne, Paul Maruff, AIBL Research Group Abstract: Background: Only one study has investigated the relationship between cerebral β-amyloid (Aβ), apolipoprotein E (APOE) ɛ4 genotype, and cognition. Although significant relationships between cerebral Aβ and cognition were observed in ɛ4 carriers but not noncarriers, the magnitude of this relationship was not reported. Further, when demographic variables were controlled, Read & Research Alzheimer’s More

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By G. Stennis Watson, Brenna A. Cholerton, Rachel G. Gross, Daniel Weintraub, Cyrus P. Zabetian, John Q. Trojanowski, Thomas J. Montine, Andrew Siderowf, James B. Leverenz Abstract: Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson’s disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson’s Disease Research were supported by the National Institute of Neurological Disorders and Read & Research Alzheimer’s More

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By Ge Li, Lynn M. Bekris, Lesley Leong, Ellen J. Steinbart, Jane B. Shofer, Paul K. Crane, Eric B. Larson, Elaine R. Peskind, Thomas D. Bird, Chang-En Yu Abstract: Background: This study investigates the association between TOMM40 poly-T length, age at onset, and neuropathology in individuals with Alzheimer’s disease (AD) with the apolipoprotein E (APOE) ɛ3/ɛ3 allele.Methods: Thirty-two presenilin 1 (PSEN1) mutation carriers with AD, 27 presenilin 2 (PSEN2) mutation carriers with AD, 59 participants with late-onset AD Read & Research Alzheimer’s More

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By Sara Kaffashian, Aline Dugravot, Eric J. Brunner, Séverine Sabia, Joël Ankri, Mika Kivimäki, Archana Singh-Manoux Abstract: Background: Stroke is associated with an increased risk of dementia. However, it is unclear whether risk of stroke in those free of stroke, particularly in nonelderly populations, leads to differential rates of cognitive decline. Our aim was to assess whether risk of stroke in mid life is associated with Read & Research Alzheimer’s More

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By Davide L. Vetrano, Matteo Tosato, Giuseppe Colloca, Eva Topinkova, Daniela Fialova, Jacob Gindin, Henriëtte G. van der Roest, Francesco Landi, Rosa Liperoti, Roberto Bernabei, Graziano Onder, SHELTER Study Abstract: Objective: Pharmacological treatment of older adults with cognitive impairment represents a challenge for prescribing physicians, and polypharmacy is common in these complex patients. The aim of the current study is to assess prevalence and factors related to polypharmacy in a sample of nursing home (nursing home) residents with advanced Read & Research Alzheimer’s More

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