Archive for November, 2013

Figures published on Friday 29 November in the ‘State of the Nation’ report released by the Department of Health show that less than half of people with dementia receive a diagnosis, with huge disparities in support across the country, leaving people with the condition in the dark. Read & Research Alzheimer’s More

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Although we know that mild cognitive impairment is a transitional stage between normal aging and Alzheimer’s disease, changes in brain networks during this transformation have yet to be studied. Dr. Read & Research Alzheimer’s More

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A method by Rice University researchers to model the way proteins fold – and sometimes misfold – has revealed branching behavior that may have implications for Alzheimer’s and other aggregation diseases.Results from the research appear online in the Proceedings of the National Academy of Sciences. Read & Research Alzheimer’s More

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Studies on Alzheimer’s disease and other forms of dementia have long focused on what’s happening inside the brain. Now an international research team studying Alzheimer’s and mild cognitive impairment is reporting potentially significant findings on a vascular abnormality outside the brain. Read & Research Alzheimer’s More

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A new discovery may help explain the surprisingly strong connections between sleep problems and neurodegenerative conditions such as Alzheimer’s disease. Sleep loss increases the risk of Alzheimer’s disease, and disrupted sleeping patterns are among the first signs of this devastating disorder.Scientists at Washington University School of Medicine in St. Read & Research Alzheimer’s More

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Using a powerful laser imaging technique, a study led by the University of Cambridge in the UK shows how tiny pieces of a protein linked with Alzheimer’s Disease could be the start of a process that leads to the onset and spread of the disease. The researchers also cautiously suggest Read & Research Alzheimer’s More

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Stanford University School of Medicine neuroscientists have discovered a new role played by a common but mysterious class of brain cells. Read & Research Alzheimer’s More

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It’s never too late to get physically active, with even those starting relatively late in life reaping significant health benefits, finds research published online in the British Journal of Sports Medicine.Four years of sustained regular physical activity boosted the likelihood of healthy ageing sevenfold compared with consistent inactivity, the findings Read & Research Alzheimer’s More

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Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late-onset form of Alzheimer’s disease, but exactly how that variant confers increased risk has been controversial among researchers. Read & Research Alzheimer’s More

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Lay-offs, lower pay and downward job mobility are all a depressing reality of economic recessions. But new research suggests these factors not only affect our bank accounts, but also our risk of cognitive decline in later life. Read & Research Alzheimer’s More

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Cognitively impaired older adults released from the hospital are less likely to be rehospitalized within 30 days if they go to a nursing home than if they return to their own home or the home of a family member, according to an Indiana University and Regenstrief Institute study. Read & Research Alzheimer’s More

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It’s well known that the brains of meditators change, but it’s not entirely clear what those changes mean or how the changes might benefit the meditator. Read & Research Alzheimer’s More

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A systematic review of available evidence (low- to moderate-strength) did not find a link between statin use and adverse cognitive outcomes, according to a study published in Annals of Internal Medicine. Recently, the FDA issued a warning after case reports suggested that statin use may lead to cognitive impairment. Read & Research Alzheimer’s More

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The health benefits of spearmint and rosemary have been described for years in numerous studies, but new research in mice suggests that antioxidants from spearmint and rosemary made into an enhanced extract can improve learning and memory, potentially helping with age-related cognitive decline.Prof. Read & Research Alzheimer’s More

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Researchers at the University of California, San Diego School of Medicine have used genetic engineering of human induced pluripotent stem cells to specifically and precisely parse the roles of a key mutated protein in causing familial Alzheimer’s disease (AD), discovering that simple loss-of-function does not contribute to the inherited form Read & Research Alzheimer’s More

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Massachusetts General Hospital (MGH) investigators have used a new sequencing method to identify a group of genes used by the brain’s immune cells – called microglia – to sense pathogenic organisms, toxins or damaged cells that require their response. Read & Research Alzheimer’s More

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In recent years, the link between type 2 diabetes and dementia has become widely recognized. Older individuals with diabetes develop Alzheimer’s disease at an earlier age, and are more likely to develop vascular dementia than people who do not have diabetes. Read & Research Alzheimer’s More

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An international team of researchers studying the link between vision loss and Alzheimer’s disease report that the loss of a particular layer of retinal cells not previously investigated may reveal the disease’s presence and provide a new way to track disease progression. Read & Research Alzheimer’s More

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A new study published in the journal JAMA Ophthalmology suggests there is no association between age-related macular degeneration and dementia or Alzheimer’s disease, opposing previous research that has indicated otherwise. Age-related macular degeneration (AMD) and Alzheimer’s disease are both conditions that commonly develop alongside increasing age. Read & Research Alzheimer’s More

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A study of patients in England with the eye disease age-related macular degeneration (AMD) found no association between having AMD and subsequently developing dementia or Alzheimer disease (AD), according to a report published by JAMA Ophthalmology, a JAMA Network publication. AMD and AD are diseases strongly associated with advancing age. Read & Research Alzheimer’s More

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The novel compound IRL-1620 may be useful in treating Alzheimer’s disease (AD) as it has been shown to prevent cognitive impairment and oxidative stress in animal models. This research is being presented at the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world’s largest pharmaceutical sciences Read & Research Alzheimer’s More

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New research has suggested that middle-aged people who have high pulse pressure – a measure of high blood pressure – are more likely to have biomarkers of Alzheimer’s disease in their spinal fluid, compared with people who have lower pulse pressure.Pulse pressure is defined as the highest number in a Read & Research Alzheimer’s More

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Using scores obtained from cognitive tests, Johns Hopkins researchers think they have developed a model that could help determine whether memory loss in older adults is benign or a stop on the way to Alzheimer’s disease. Read & Research Alzheimer’s More

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A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells’ progeny, Johns Hopkins researchers report… Read & Research Alzheimer’s More

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According to the Alzheimer’s Association, there are more than 5 million people in the US living with Alzheimer’s disease. But researchers say they have developed a new model that could improve early detection of dementia, allowing better treatment options and potentially slowing the development of Alzheimer’s disease… Read & Research Alzheimer’s More

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Patients with traumatic brain injury (TBI) had increased deposits of β-Amyloid (Aβ) plaques, a hallmark of Alzheimer Disease (AD), in some areas of their brains in a study by Young T. Hong, Ph.D., of the University of Cambridge, England, and colleagues… Read & Research Alzheimer’s More

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A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to full-time care, nursing home residence, or death for patients with Alzheimer’s disease… Read & Research Alzheimer’s More

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As the population of older adults continues to grow, researchers at the University of Kentucky Sanders-Brown Center on Aging are engaged in work to understand the mechanisms of a variety of diseases that predominately affect those of advanced age. Three recent papers authored by Dr… Read & Research Alzheimer’s More

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To survive, animals must explore their world to find the necessities of life. It’s a complex task, requiring them to form them a mental map of their environment to navigate the safest and fastest routes to food and water. They also learn to anticipate when and where certain important events, Read & Research Alzheimer’s More

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By Miia Kivipelto, Alina Solomon, Satu Ahtiluoto, Tiia Ngandu, Jenni Lehtisalo, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Antti Jula, Tiina Laatikainen, Jaana Lindström, Francesca Mangialasche, Aulikki Nissinen, Teemu Paajanen, Satu Pajala, Markku Peltonen, Rainer Rauramaa, Anna Stigsdotter-Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen Abstract: Background: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland.Materials: Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the Read & Research Alzheimer’s More

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