Archive for December, 2013

Scientists from the University of Queensland in Australia say they have discovered that a gene called mec-17 has the ability to protect against adult-onset progressive nerve degeneration. This is according to a study published in the journal Cell Reports.The research team, led by Dr. Read & Research Alzheimer’s More

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High good and low bad cholesterol are not just good for the heart but also the brain, suggests new research published in JAMA Neurology. Read & Research Alzheimer’s More

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Hypothyroidism was not associated with mild cognitive impairment (MCI) in a study of older patients, according to a report published by JAMA Neurology, a JAMA Network publication. Some evidence has suggested that changes in the endocrine system, including thyroid function, may be linked to the development of Alzheimer disease and Read & Research Alzheimer’s More

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Living at home with dementia"> Living at home with dementia

Posted December 30, 2013 By FuckAlzheimers

Most people with dementia who live at home have multiple unmet health and welfare needs, any number of which could jeopardize their ability to remain home for as long as they desire, new Johns Hopkins research suggests. Read & Research Alzheimer’s More

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Alzheimer’s disease has become an increasing burden in older patients, which is why research into its causes is a high priority. Now, a new study links concussion history and Alzheimer’s, suggesting loss of consciousness could be associated with the build-up of plaques in the brain. Read & Research Alzheimer’s More

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Researchers at Penn State University have developed an innovative technology to regenerate functional neurons after brain injury, and also in model systems used for research on Alzheimer’s disease. The scientists have used supporting cells of the central nervous system, glial cells, to regenerate healthy, functional neurons, which are critical for Read & Research Alzheimer’s More

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The Alzheimer’s Prevention Initiative (API) trial in cognitively healthy individuals has reached a significant milestone with the first participants in Colombia receiving doses of an experimental anti-amyloid antibody, crenezumab designed to delay or prevent the onset of Alzheimer’s disease. Read & Research Alzheimer’s More

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A new study suggests that a history of concussion involving at least a momentary loss of consciousness may be related to the buildup of Alzheimer’s disease-associated plaques in the brain. The research is published in the December 26, 2013, online issue of Neurology

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Heart disease may put older postmenopausal women at higher risk for decreased brain function such as dementia, according to new research in Journal of the American Heart Association.”Our study provides further new evidence that this relationship (between heart disease and dementia) does exist, especially among postmenopausal women,” said study author Read & Research Alzheimer’s More

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By Frank Jessen, Steffen Wolfsgruber, Birgitt Wiese, Horst Bickel, Edelgard Mösch, Hanna Kaduszkiewicz, Michael Pentzek, Steffi G. Riedel-Heller, Tobias Luck, Angela Fuchs, Siegfried Weyerer, Jochen Werle, Hendrik van den Bussche, Martin Scherer, Wolfgang Maier, Michael Wagner, German Study on Aging, Cognition and Dementia in Primary Care Patients Abstract: Objective: To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.Methods: The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Read & Research Alzheimer’s More

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By Joanne Ryan, Isabelle Carrière, Laure Carcaillon, Jean-Francois Dartigues, Sophie Auriacombe, Olivier Rouaud, Claudine Berr, Karen Ritchie, Pierre-Yves Scarabin, Marie-Laure Ancelin Abstract: Background: Genetic variation in the estrogen receptor (ESR) may be associated with the incidence of Alzheimer’s disease (AD), but this association could be modified by genetic and environmental factors.Methods: The association between five ESR α (ESR1) and β (ESR2) polymorphisms with 7-year dementia incidence was examined among 6959 older Read & Research Alzheimer’s More

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By Alan Rembach, Noel G. Faux, Andrew D. Watt, Kelly K. Pertile, Rebecca L. Rumble, Brett O. Trounson, Christopher J. Fowler, Blaine R. Roberts, Keyla A. Perez, Qiao-Xin Li, Simon M. Laws, Kevin Taddei, Stephanie Rainey-Smith, Joanne S. Robertson, Manu Vandijck, Hugo Vanderstichele, Kevin J. Barnham, Kathryn A. Ellis, Cassandra Szoeke, Lance Macaulay, Christopher C. Rowe, Victor L. Villemagne, David Ames, Ralph N. Martins, Ashley I. Bush, Colin L. Masters, AIBL research group Abstract: Background: A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer’s disease (AD).Methods: Plasma amyloid beta (Aβ)1–40, Aβ1–42, Aβn–40, and Aβn–42 peptides were measured at baseline and after 18 months in 771 participants from the Australian Imaging Biomarkers and Lifestyle (AIBL) study of aging. Aβ peptide levels Read & Research Alzheimer’s More

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By Richard Sherva, Yorghos Tripodis, David A. Bennett, Lori B. Chibnik, Paul K. Crane, Philip L. de Jager, Lindsay A. Farrer, Andrew J. Saykin, Joshua M. Shulman, Adam Naj, Robert C. Green, The GENAROAD Consortium, The Alzheimer’s Disease Neuroimaging Initiative, and The Alzheimer’s Disease Genetics Consortium Abstract: Background: Substantial interindividual variability exists in the disease trajectories of Alzheimer’s disease (AD) patients. Some decline rapidly whereas others decline slowly, and there are no known explanations for this variability. We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients Read & Research Alzheimer’s More

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By Richard J. Caselli, Dona E.C. Locke, Amylou C. Dueck, David S. Knopman, Bryan K. Woodruff, Charlene Hoffman-Snyder, Rosa Rademakers, Adam S. Fleisher, Eric M. Reiman Abstract: Objective: A National Institute on Aging–sponsored work group on preclinical Alzheimer’s disease (AD) articulated the need to characterize cognitive differences between normal aging and preclinical AD.Methods: Seventy-one apolipoprotein E (APOE) ε4 homozygotes, 194 ε3/ε4 heterozygotes, and 356 ε4 noncarriers age 21 to 87 years who were cognitively healthy underwent Read & Research Alzheimer’s More

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By Shanker Swaminathan, Shannon L. Risacher, Karmen K. Yoder, John D. West, Li Shen, Sungeun Kim, Mark Inlow, Tatiana Foroud, William J. Jagust, Robert A. Koeppe, Chester A. Mathis, Leslie M. Shaw, John Q. Trojanowski, Holly Soares, Paul S. Aisen, Ronald C. Petersen, Michael W. Weiner, Andrew J. Saykin, Alzheimer’s Disease Neuroimaging Initiative Abstract: Background: Apolipoprotein E (APOE) ε4 allele’s role as a modulator of the relationship between soluble plasma amyloid beta (Aβ) and fibrillar brain Aβ measured by Pittsburgh compound B positron emission tomography ([11C]PiB PET) has not been assessed.Methods: Ninety-six Alzheimer’s Disease Neuroimaging Initiative participants with [11C]PiB scans and plasma Aβ1–40 Read & Research Alzheimer’s More

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By Richard J. Caselli, Kewei Chen, Dona E.C. Locke, Wendy Lee, Auttawut Roontiva, Dan Bandy, Adam S. Fleisher, Eric M. Reiman Abstract: Background: It is unclear whether self- or informant-based subjective cognition better distinguishes emotional factors from early-stage Alzheimer’s disease (AD).Methods: Healthy members (n = 447) of the Arizona apolipoprotein E (APOE) cohort and their informants completed the self and informant paired Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS).Results: Decline on Read & Research Alzheimer’s More

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By Jennifer L. Whitwell, Clifford R. Jack, Joseph R. Duffy, Edythe A. Strand, Jeffrey L. Gunter, Matthew L. Senjem, Matthew C. Murphy, Kejal Kantarci, Mary M. Machulda, Val J. Lowe, Keith A. Josephs Abstract: Background: Microbleeds have been associated with Alzheimer’s disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA.Methods: Thirteen lvPPA subjects underwent 3T Read & Research Alzheimer’s More

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By Rosebud O. Roberts, David S. Knopman, Yonas E. Geda, Ruth H. Cha, V. Shane Pankratz, Luke Baertlein, Bradley F. Boeve, Eric G. Tangalos, Robert J. Ivnik, Michelle M. Mielke, Ronald C. Petersen Abstract: Background: Type 2 diabetes may increase the risk of amnestic mild cognitive impairment (aMCI) through Alzheimer’s disease (AD)-related and vascular pathology and may also increase the risk of nonamnestic MCI (naMCI) through vascular disease mechanisms. We examined the association of type 2 diabetes with mild cognitive impairment (MCI) and Read & Research Alzheimer’s More

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By Maurice W. Dysken, Peter D. Guarino, Julia E. Vertrees, Sanjay Asthana, Mary Sano, Maria Llorente, Muralidhar Pallaki, Susan Love, Gerard D. Schellenberg, J. Riley McCarten, Julie Malphurs, Susana Prieto, Peijun Chen, David J. Loreck, Sara Carney, George Trapp, Rajbir S. Bakshi, Jacobo E. Mintzer, Judith L. Heidebrink, Ana Vidal-Cardona, Lillian M. Arroyo, Angel R. Cruz, Neil W. Kowall, Mohit P. Chopra, Suzanne Craft, Stephen Thielke, Carolyn L. Turvey, Catherine Woodman, Kimberly A. Monnell, Kimberly Gordon, Julie Tomaska, Govind Vatassery Abstract: Background: Alzheimer’s disease (AD) has been associated with both oxidative stress and excessive glutamate activity. A clinical trial was designed to compare the effectiveness of (i) alpha-tocopherol, a vitamin E antioxidant; (ii) memantine (Namenda), an N-methyl-D-aspartate antagonist; (iii) their combination; and (iv) placebo in delaying clinical progression in AD.Methods: Read & Research Alzheimer’s More

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By Cynthia M. Stonnington, Kewei Chen, Wendy Lee, Dona E.C. Locke, Amylou C. Dueck, Xiaofen Liu, Auttawut Roontiva, Adam S. Fleisher, Richard J. Caselli, Eric M. Reiman Abstract: Background: It is not known whether preclinical cognitive decline is associated with fibrillar β-amyloid (Aβ) deposition irrespective of apolipoprotein E (APOE) ε4 status.Methods: From a prospective observational study of 623 cognitively normal individuals, we identified all subjects who showed preclinical decline of at least 2 standard deviations beyond the Read & Research Alzheimer’s More

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By Jeffrey Kaye, Nora Mattek, Hiroko H. Dodge, Ian Campbell, Tamara Hayes, Daniel Austin, William Hatt, Katherine Wild, Holly Jimison, Michael Pavel Abstract: Background: Mild disturbances of higher order activities of daily living are present in people diagnosed with mild cognitive impairment (MCI). These deficits may be difficult to detect among those still living independently. Unobtrusive continuous assessment of a complex activity such as home computer use may detect mild functional changes Read & Research Alzheimer’s More

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By Shantel L. Duffy, Jim Lagopoulos, Ian B. Hickie, Keri Diamond, Manuel B. Graeber, Simon J.G. Lewis, Sharon L. Naismith Abstract: Background: Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer’s disease in which underlying pathophysiological mechanisms could be delineated. Oxidative stress has been implicated in Alzheimer’s disease and can be measured by levels of the antioxidant glutathione. This study aims to assess in vivo levels of glutathione via proton Read & Research Alzheimer’s More

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By Sanneke van Rooden, Maarten J. Versluis, Michael K. Liem, Julien Milles, Andrea B. Maier, Ania M. Oleksik, Andrew G. Webb, Mark A. van Buchem, Jeroen van der Grond Abstract: Background: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer’s disease (AD).Methods: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. Read & Research Alzheimer’s More

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By Kim Henriksen, Sid E. O’Bryant, Harald Hampel, John Q. Trojanowski, Thomas J. Montine, Andreas Jeromin, Kaj Blennow, Anders Lönneborg, Tony Wyss-Coray, Holly Soares, Chantal Bazenet, Magnus Sjögren, William Hu, Simon Lovestone, Morten A. Karsdal, Michael W. Weiner, Blood-Based Biomarker Interest Group Abstract: Treatment of Alzheimer’s disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease progression or treatment response, and most Read & Research Alzheimer’s More

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By Jessica Peter, Lukas Scheef, Ahmed Abdulkadir, Henning Boecker, Michael Heneka, Michael Wagner, Alexander Koppara, Stefan Klöppel, Frank Jessen, Alzheimer’s Disease Neuroimaging Initiative Abstract: Background: Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI.Methods: We used a discriminative function (a support vector machine) trained on an independent data set Read & Research Alzheimer’s More

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By Jianping Jia, Fen Wang, Cuibai Wei, Aihong Zhou, Xiangfei Jia, Fang Li, Muni Tang, Lan Chu, Youlong Zhou, Chunkui Zhou, Yong Cui, Qi Wang, Weishan Wang, Peng Yin, Nan Hu, Xiumei Zuo, Haiqing Song, Wei Qin, Liyong Wu, Dan Li, Longfei Jia, Juexian Song, Ying Han, Yi Xing, Peijie Yang, Yuemei Li, Yuchen Qiao, Yi Tang, Jihui Lv, Xiumin Dong Abstract: Objective: The Chinese population has been aging rapidly and the country’s economy has experienced exponential growth during the past three decades. The goal of this study was to estimate the changes in the prevalence of dementia, Alzheimer’s disease (AD), and vascular dementia (VaD) among elderly Chinese individuals and to Read & Research Alzheimer’s More

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One of the first areas of the brain to be attacked by Alzheimer’s disease is more active when the brain isn’t working very hard, and quiets down during the brain’s peak performance. Read & Research Alzheimer’s More

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In a sort of biological “spooky action at a distance,” water in a cell slows down in the tightest confines between proteins and develops the ability to affect other proteins much farther away, University of Michigan researchers have discovered.On a fundamental level, the findings show some of the complex and Read & Research Alzheimer’s More

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By Heather M. Snyder, Maria C. Carrillo, Francine Grodstein, Kim Henriksen, Andreas Jeromin, Simon Lovestone, Michelle M. Mielke, Sid O’Bryant, Manual Sarasa, Magnus Sjøgren, Holly Soares, Jessica Teeling, Eugenia Trushina, Malcolm Ward, Tim West, Lisa J. Bain, Diana W. Shineman, Michael Weiner, Howard M. Fillit Abstract: Alzheimer’s disease is the public health crisis of the 21st century. There is a clear need for a widely available, inexpensive and reliable method to diagnosis Alzheimer’s disease in the earliest stages, track disease progression, and accelerate clinical development of new therapeutics. One avenue of research being explored is blood Read & Research Alzheimer’s More

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Research evidence continues to support the concept that the biological changes associated with Alzheimer’s disease (AD) begin occurring a decade or more before an individual will experience cognitive changes such as problems with memory. With this growing understanding, several research groups are gearing up to launch large prevention trials to Read & Research Alzheimer’s More

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