Archive for March, 2014

Anavex Life Sciences Corp., a clinical stage biopharmaceutical company developing novel drug candidates to treat Alzheimer’s, diseases of the central nervous system (CNS) and various types of cancer, has announced that a report in the current issue of peer-reviewed International Pharmaceutical Industry Journal (“IPI Journal”) predicts that ANAVEX 2-73 will Read & Research Alzheimer’s More

Be the first to comment

Mitochondria, long known as “cellular power plants” for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Read & Research Alzheimer’s More

Be the first to comment

Scientists at the University of Southampton have been able to provide new insights into the inflammatory reaction that occurs in the brain during neurodegenerative diseases, by studying the behaviour of the brain’s immune cells. Read & Research Alzheimer’s More

Be the first to comment

Researchers have suggested that alterations in eye movements when reading could be linked to impairments in working memory and an early indication of Alzheimer’s disease according to a new study published in the Journal of Clinical and Experimental Neuropsychology.The study focussed on a group of 18 patients with a diagnosis Read & Research Alzheimer’s More

Be the first to comment

Developing treatments that slow, if not halt, the neuronal loss and cognitive decline of Alzheimer’s disease (AD) has proven to be a challenge. Among the scientists who have taken on that challenge are researchers at the University of Florida’s McKnight Brain Institute in Gainesville, using the fruit fly Drosophila melanogaster Read & Research Alzheimer’s More

Be the first to comment

Research over decades has implicated aberrant autophagy and lysosomal function as reliable markers and therapeutic targets for neurodegenerative diseases. Lipid rafts are shown to participate in lysosomal reproduction, and some lysosomal storage diseases are proposed to result from the accumulation of lipids in late endosomal/lysosomal compartments. Prof. Read & Research Alzheimer’s More

Be the first to comment

Transforming growth factor-beta (TGF-β) type II receptor (TβRII) levels are extremely low in the brain tissue of patients with Alzheimer’s disease. This receptor inhibits TGF-β1/SMAD signaling and thereby aggravates amyolid-beta deposition and neuronal injury. Read & Research Alzheimer’s More

Be the first to comment

Protein fragments that comprise Alzheimer’s lesions have been implicated as a hallmark of the disease, but until now, why they accumulate or cause brain cells to die has not been understood. Now, researchers have used giant X-ray centers – called synchrotrons – to investigate and have found that biological material Read & Research Alzheimer’s More

Be the first to comment

Prions are infectious agents responsible for neurodegenerative diseases such as bovine spongiform encephalitis (commonly known as “mad cow disease”) and Creutzfeldt-Jakob disease in humans. Read & Research Alzheimer’s More

Be the first to comment

1. USPSTF finds insufficient evidence to recommend routine screening for cognitive declineThe United States Preventive Services Task Force (USPSTF) found insufficient evidence to recommend routine screening for cognitive decline in older adults in the primary care setting. Dementia affects up to 5.5 million Americans and its prevalence increases with age. Read & Research Alzheimer’s More

Be the first to comment

Researchers from Boston University School of Medicine (BUSM) have found that the diabetic drug, pramlintide, reduces amyloid-beta peptides, a major component of Alzheimer’s disease (AD) in the brain and improves learning and memory in two experimental AD models. Read & Research Alzheimer’s More

Be the first to comment

Family caregivers show an increase in the beneficial stress hormone DHEA-S on days when they use an adult day care service for their relatives with dementia, according to researchers at Penn State and the University of Texas at Austin.DHEA-S controls the harmful effects of cortisol and is associated with better Read & Research Alzheimer’s More

Be the first to comment

The United States Preventive Services Task Force (USPSTF) found insufficient evidence to recommend routine screening for cognitive decline in older adults in the primary care setting. Dementia affects up to 5.5 million Americans and its prevalence increases with age. Read & Research Alzheimer’s More

Be the first to comment

Scientists studying the genomes of nearly 5,000 people have pinpointed a genetic variant tied to an increased risk for stroke, and have also uncovered new details about an important metabolic pathway that plays a major role in several common diseases. Read & Research Alzheimer’s More

Be the first to comment

Researchers have shown that they can detect tiny, misfolded protein fragments in cerebrospinal fluid taken from patients. Such fragments have been suggested to be the main culprit in Alzheimer’s disease. Read & Research Alzheimer’s More

Be the first to comment

Researchers at the University of Texas Medical Branch at Galveston have discovered a way to potentially halt the progression of dementia caused by accumulation of a protein known as tau.Normally, tau protein is involved in microtubule formation, which acts as a brain cell’s transportation system for carrying nutrients in and Read & Research Alzheimer’s More

Be the first to comment

A new clinical trial will soon begin testing whether early medical intervention in people at risk for Alzheimer’s can slow down progression of disease pathology before symptoms emerge, as outlined in Science Translational Medicine. For the first time, people with no Alzheimer’s disease symptoms will be told of their risk Read & Research Alzheimer’s More

Be the first to comment

Why do neurodegenerative diseases such as Alzheimer’s affect only the elderly? Why do some people live to be over 100 with intact cognitive function while others develop dementia decades earlier?More than a century of research into the causes of dementia has focused on the clumps and tangles of abnormal proteins Read & Research Alzheimer’s More

Be the first to comment

New research is expanding scientists’ understanding of how the human brain processes music. We take a look at recent projects examining the interactions of music and neurology and ask what benefits this knowledge might have therapeutically or for future research.Doctors have long known that listening to music can cause physiological Read & Research Alzheimer’s More

Be the first to comment

Past studies have linked diabetes to increased risk of cognitive decline. Now, new research suggests that people who develop diabetes and high blood pressure in middle age may be at higher risk of brain cell loss and memory and thinking problems, compared with those who do not have either condition Read & Research Alzheimer’s More

Be the first to comment

Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer’s disease. Using a novel laboratory rat model of Alzheimer’s disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease. Read & Research Alzheimer’s More

Be the first to comment

University of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer’s patients and appears to be a major cause of the disease. Read & Research Alzheimer’s More

Be the first to comment

The PredictND project, started by European research organisations, aims at developing and validating new procedures for the earlier diagnosis of memory disorders and for detecting individuals at high risk of developing memory disorders. Millions of Europeans who are at risk for experiencing any kind of memory loss would benefit from Read & Research Alzheimer’s More

Be the first to comment

As women get older, it is well known that the risk of developing breast cancer increases. But a new report from the Alzheimer’s Association finds that women in their 60s are twice as likely to develop Alzheimer’s disease over the rest of their lives as they are breast cancer. Read & Research Alzheimer’s More

Be the first to comment

Chronic sleep problems can inflame a number of health problems, from widespread pain to speeding up cancer. Though sleep disturbances have been observed in people with Alzheimer’s disease, whether this is a cause or effect has been unknown. Now, researchers say individuals with chronic sleep disruptions could face earlier onset Read & Research Alzheimer’s More

Be the first to comment

In order to function properly, the human brain requires the ability not only to store but also to forget: Through memory loss, unnecessary information is deleted and the nervous system retains its plasticity. A disruption of this process can lead to serious mental disorders. Basel scientists have now discovered a Read & Research Alzheimer’s More

Be the first to comment

Brain damage caught in the act"> Brain damage caught in the act

Posted March 17, 2014 By FuckAlzheimers

Scientists have uncovered how inflammation and lack of oxygen conspire to cause brain damage in conditions such as stroke and Alzheimer’s disease.The discovery, published in Neuron, brings researchers a step closer to finding potential targets to treat neurodegenerative disorders. Read & Research Alzheimer’s More

Be the first to comment

When initiated soon after menopause, hormone therapy with estradiol prevented degeneration in key brain regions of women who were at heightened dementia risk, according to a new study led by Stanford University School of Medicine researchers.The investigators also found that another type of hormone therapy, marketed under the brand name Read & Research Alzheimer’s More

Be the first to comment

European populations are growing older on average, a trend that could pose serious challenges to health care, budgets, and economic growth. As a greater proportion of a country’s population grows into old age, average cognition levels and national productivity tend to decline, and the incidence of dementia increases. Read & Research Alzheimer’s More

Be the first to comment

Alzheimer’s disease is the most widespread degenerative neurological disorder in the world. Over five million Americans live with it, and one in three senior citizens will die with the disease or a similar form of dementia. Read & Research Alzheimer’s More

Be the first to comment