Archive for June, 2014

By Miharu Nakanishi, Taeko Nakashima Abstract: Background: The Ministry of Health, Labour, and Welfare of the Japanese national government announced a “Five-Year Plan for Promotion of Measures Against Dementia (Orange Plan)” in September 2012. This article described features of the Japanese dementia strategy in comparison with international dementia policies.Methods: An international comparative study was implemented Read & Research Alzheimer’s More

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By Jon B. Toledo, Vivianna M. Van Deerlin, Edward B. Lee, EunRan Suh, Young Baek, John L. Robinson, Sharon X. Xie, Jennifer McBride, Elisabeth M. Wood, Theresa Schuck, David J. Irwin, Rachel G. Gross, Howard Hurtig, Leo McCluskey, Lauren Elman, Jason Karlawish, Gerard Schellenberg, Alice Chen-Plotkin, David Wolk, Murray Grossman, Steven E. Arnold, Leslie M. Shaw, Virginia M.-Y. Lee, John Q. Trojanowski Abstract: Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new Read & Research Alzheimer’s More

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By Andrea Chincarini, Paolo Bosco, Gianluca Gemme, Mario Esposito, Luca Rei, Sandro Squarcia, Roberto Bellotti, Lennart Minthon, Giovanni Frisoni, Philip Scheltens, Lutz Frölich, Hilkka Soininen, Pieter-Jelle Visser, Flavio Nobili, Alzheimer’s Disease Neuroimaging Initiative Abstract: Background: In the framework of the clinical validation of research tools, this investigation presents a validation study of an automatic medial temporal lobe atrophy measure that is applied to a naturalistic population sampled from memory clinic patients across Europe.Methods: The procedure was developed on 1.5-T magnetic resonance images from the Read & Research Alzheimer’s More

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By Sofia Lopes da Silva, Bruno Vellas, Saskia Elemans, José Luchsinger, Patrick Kamphuis, Kristine Yaffe, John Sijben, Martine Groenendijk, Theo Stijnen Abstract: Background: Alzheimer disease (AD) patients are at risk of nutritional insufficiencies because of physiological and psychological factors. Nutritional compounds are postulated to play a role in the pathophysiological processes that are affected in AD. We here provide the first systematic review and meta-analysis that compares plasma levels of micronutrients Read & Research Alzheimer’s More

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By Megan K. Herbert, Marjolein B. Aerts, H. Bea Kuiperij, Jurgen A.H.R. Claassen, Petra E. Spies, Rianne A.J. Esselink, Bastiaan R. Bloem, Marcel M. Verbeek Abstract: Background: Overlapping clinical features make it difficult to distinguish dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) and other dementia types. In this study we aimed to determine whether the combination of cerebrospinal fluid (CSF) biomarkers, amyloid-β42 (Aβ42), total tau protein (t-tau), and phosphorylated tau protein (p-tau), in Read & Research Alzheimer’s More

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By Jianping Jia, Aihong Zhou, Cuibai Wei, Xiangfei Jia, Fen Wang, Fang Li, Xiaoguang Wu, Vincent Mok, Serge Gauthier, Muni Tang, Lan Chu, Youlong Zhou, Chunkui Zhou, Yong Cui, Qi Wang, Weishan Wang, Peng Yin, Nan Hu, Xiumei Zuo, Haiqing Song, Wei Qin, Liyong Wu, Dan Li, Longfei Jia, Juexian Song, Ying Han, Yi Xing, Peijie Yang, Yuemei Li, Yuchen Qiao, Yi Tang, Jihui Lv, Xiumin Dong Abstract: Background: Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Methods: Using a multistage cluster sampling design, a total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, or dementia. MCI was further categorized by imaging into MCI Read & Research Alzheimer’s More

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Subscriber information"> Subscriber information

Posted June 30, 2014 By FuckAlzheimers

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By Robin Wolz, Adam J. Schwarz, Peng Yu, Patricia E. Cole, Daniel Rueckert, Clifford R. Jack, David Raunig, Derek Hill, The Alzheimer’s Disease Neuroimaging Initiative Abstract: Background: Low HCV has recently been qualified by the European Medicines Agency as a biomarker for enrichment of clinical trials in predementia stages of Alzheimer’s disease. For automated methods to meet the necessary regulatory requirements, it is essential they be standardized and their performance be well characterized.Methods: The within-image Read & Research Alzheimer’s More

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By Norman L. Foster, Judith S.M. Hackett, Greg White, Sherri Chenevert, Patrick Svarvar, Lisa Bain, Maria C. Carrillo Abstract: The increasing cost of health care combined with expensive new drugs and diagnostics is leading to more frequent gaps between regulatory and subsequent reimbursement approval decisions. As a result, persons with Alzheimer’s disease may have difficulty accessing the benefit of medical advances. In contrast to the long history and Read & Research Alzheimer’s More

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Editorial Board"> Editorial Board

Posted June 30, 2014 By FuckAlzheimers

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Contents"> Contents

Posted June 30, 2014 By FuckAlzheimers

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By Derek L.G. Hill, Adam J. Schwarz, Maria Isaac, Luca Pani, Spiros Vamvakas, Robert Hemmings, Maria C. Carrillo, Peng Yu, Jia Sun, Laurel Beckett, Marina Boccardi, James Brewer, Martha Brumfield, Marc Cantillon, Patricia E. Cole, Nick Fox, Giovanni B. Frisoni, Clifford Jack, Thomas Kelleher, Feng Luo, Gerald Novak, Paul Maguire, Richard Meibach, Patricia Patterson, Lisa Bain, Cristina Sampaio, David Raunig, Holly Soares, Joyce Suhy, Huanli Wang, Robin Wolz, Diane Stephenson Abstract: Background: Regulatory qualification of a biomarker for a defined context of use provides scientifically robust assurances to sponsors and regulators that accelerate appropriate adoption of biomarkers into drug development.Methods: The Coalition Against Major Diseases submitted a dossier to the Scientific Advice Working Party of the European Medicines Agency requesting Read & Research Alzheimer’s More

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Alzheimer's Association Update"> Alzheimer's Association Update

Posted June 30, 2014 By FuckAlzheimers

In April, the Alzheimer’s Accountability Act was introduced in the U.S. Congress by Reps. Brett Guthrie (R-Ky.) and Paul Tonko (D-N.Y.) and Sens. Edward Markey (D-Mass.) and Mike Crapo (R-Idaho). The Alzheimer’s Accountability Act authorizes the National Institutes of Health (NIH) to submit a Professional Judgment Budget to Congress justifying Read & Research Alzheimer’s More

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A study of older veterans is suggesting that the risk of dementia may increase with traumatic brain injury. Does this have wider implications for the public? Read & Research Alzheimer’s More

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As millions of Americans struggle to help loved ones with dementia, policymakers should consider more ways to improve long-term services and supports for the soaring numbers of people with the… Read & Research Alzheimer’s More

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Researchers believe they have learned how mutations in the gene that causes Huntington’s disease kill brain cells, a finding that could open new opportunities for treating the fatal disorder. Read & Research Alzheimer’s More

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A study by researchers from the Icahn School of Medicine at Mount Sinai in New York, NY, finds a cocoa extract – called lavado – may lead to Alzheimer’s treatment and prevention. Read & Research Alzheimer’s More

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Even after a cell dies, components of the immune system remain active and continue to fuel inflammatory reactions. Read & Research Alzheimer’s More

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Brain-wasting is assumed to be unstoppable in diseases like Alzheimer’s and Parkinson’s. Now research suggests boosting natural self-repair may be possible in the early stages. Read & Research Alzheimer’s More

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More than 5 million Americans suffer from Alzheimer’s disease, the affliction that erodes memory and other mental capacities, but no drugs targeting the disease have been approved by the U.S. Read & Research Alzheimer’s More

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New research, led by scientists at the University of Southampton, has found that neurogenesis, the self-repairing mechanism of the adult brain, can help to preserve brain function in… Read & Research Alzheimer’s More

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A new study led by investigators at the Stanford University School of Medicine has implicated the blocking of endocannabinoids – signaling substances that are the brain’s internal versions of the… Read & Research Alzheimer’s More

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The Medical Research Council (MRC) has launched the UK Dementias Research Platform (UKDP), a £16 million public-private partnership set up to speed up research into dementias. Read & Research Alzheimer’s More

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There is new hope for people suffering from depression. Researchers have identified a compound, hydroxynorketamine (HNK), that may treat symptoms of depression just as effectively and rapidly as… Read & Research Alzheimer’s More

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More than 5 million Americans suffer from Alzheimer’s disease, the affliction that erodes memory and other mental capacities, but no drugs targeting the disease have been approved by the U.S. Read & Research Alzheimer’s More

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Confirming what neurocomputational theorists have long suspected, researchers at the Dignity Health Barrow Neurological Institute in Phoenix, Ariz. Read & Research Alzheimer’s More

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A new drug target to fight Alzheimer’s disease has been discovered by a research team led by Gong Chen, a Professor of Biology and the Verne M. Read & Research Alzheimer’s More

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UT Southwestern Medical Center researchers have generated fresh insights that could aid in the development of rapid-acting antidepressants for treatment-resistant depression. Read & Research Alzheimer’s More

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In a new study, scientists at the National Institutes of Health took a molecular-level journey into microtubules, the hollow cylinders inside brain cells that act as skeletons and internal highways. Read & Research Alzheimer’s More

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