Archive for January, 2015

Proposed diagnostic criteria (international working group and National Institute on Aging Alzheimer’s Association) for Alzheimer’s disease (AD) include markers of amyloidosis (abnormal cerebrospinal fluid [CSF] amyloid beta [Aβ]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on FDG-PET, and abnormal CSF tau). We aim to compare the accuracy of these biomarkers, individually Read & Research Alzheimer’s More

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The health-promoting perks of wine have attracted the spotlight recently, leaving beer in the shadows. Read & Research Alzheimer’s More

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In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown their drug candidates can target biological pathways involved in the destruction… Read & Research Alzheimer’s More

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Nature has many examples of self-assembly, and bioengineers are interested in copying or manipulating these systems to create useful new materials or devices. Read & Research Alzheimer’s More

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Researchers from the Gladstone Institutes have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer’s… Read & Research Alzheimer’s More

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Researchers from the Gladstone Institutes have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer’s… Read & Research Alzheimer’s More

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Inflammation has long been studied in Alzheimer’s, but in a counterintuitive finding reported in a new paper, University of Florida researchers have uncovered the mechanism by which… Read & Research Alzheimer’s More

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Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia – including Alzheimer’s – says large study. Read & Research Alzheimer’s More

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Implications for new therapies for brain disorders involving misfolded proteins. Read & Research Alzheimer’s More

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An international study, which included researchers from NUI Galway, has identified significant genetic factors that influence the size of structures within the brain. Read & Research Alzheimer’s More

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In the largest collaborative study of the brain to date, researchers from the Keck School of Medicine of the University of Southern California (USC) led a global consortium of 190 institutions to… Read & Research Alzheimer’s More

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A new study finds maintaining good quality of sleep as a young or middle-aged adult, rather than in older age, may benefit learning and memory later in life. Read & Research Alzheimer’s More

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Women with Alzheimer’s disease showed stable cognition for a year when a drug that is more commonly used to treat advanced prostate cancer was added to their drug regimen, according to a new study… Read & Research Alzheimer’s More

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Advanced image analysis suggests breakdown in brain’s memory and learning center can be detected before cognitive loss begins, suggesting important implications for Alzheimer’s and dementia patients. Read & Research Alzheimer’s More

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The pathologic validation of European Alzheimer’s Disease Consortium Alzheimer’s Disease Neuroimaging Center Harmonized Hippocampal Segmentation Protocol (HarP). Read & Research Alzheimer’s More

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The Journal of Alzheimer’s Disease has published the results of the first clinical trial of a Tau Aggregation Inhibitor (TAI) in Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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The use of hippocampal volumetry as a biomarker for Alzheimer’s disease (AD) requires that tracers from different laboratories comply with the same segmentation method. Here we present a platform for training and qualifying new tracers to perform the manual segmentation of the hippocampus on magnetic resonance images (MRI) following the Read & Research Alzheimer’s More

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The European Alzheimer’s Disease Consortium and Alzheimer’s Disease Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard of truth to train new tracers, and to validate automated segmentation algorithms. Training requires large and Read & Research Alzheimer’s More

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Corrigendum"> Corrigendum

Posted January 20, 2015 By

Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, et al. CSF biomarker variability in the Alzheimer’s Association quality control program. Alzheimers Dement 2013;9:251-61. Read & Research Alzheimer’s More

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How far north a person lives could influence their risk of developing dementia, a study suggests. Read & Research Alzheimer’s More

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Dementia costs are critical for influencing healthcare policy, but limited longitudinal information exists. We examined longitudinal informal care costs of dementia in a population-based sample. Read & Research Alzheimer’s More

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A growing body of research suggests that the most common cause of dementia in older people is a mix of vascular and Alzheimer’s-related brain abnormalities, and that approximately half of people… Read & Research Alzheimer’s More

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The members of the EPAD initiative have announced the start of a novel collaboration between academic and private sectors to test innovative treatments for the prevention of Alzheimer’s dementia. Read & Research Alzheimer’s More

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Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer’s disease can be reduced when sugars are prevented from binding to one of the… Read & Research Alzheimer’s More

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This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire© (A-IADL-Q). Read & Research Alzheimer’s More

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Research published by the Journal of the Royal Society of Medicine concludes that patients admitted to hospital from care homes are commonly dehydrated on admission and consequently appear to… Read & Research Alzheimer’s More

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A growing body of research suggests that the most common cause of dementia in older people is a mix of vascular and Alzheimer’s-related brain abnormalities, and that approximately half of people who… Read & Research Alzheimer’s More

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While considered a delicacy in some parts of the world, snails have found a more intriguing use to scientists and the medical profession offering a plethora of research possibilities. Read & Research Alzheimer’s More

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A simple method to sense DNA, as well as potential biomarker proteins of cancer or other diseases such as Alzheimer’s, may soon be within reach – thanks to the work of a team of Yokohama National… Read & Research Alzheimer’s More

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Depression and other behavior changes may show up in people who will later develop Alzheimer’s disease even before they start having memory problems, according to a new study published in the… Read & Research Alzheimer’s More

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