Archive for April, 2015

Treatment with a new compound that precisely targets and blocks only amyloid precursor protein reduced plaque accumulation by 50% in Alzheimer’s mice after 2 weeks. Read & Research Alzheimer’s More

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Updates reflect expert review of new research on several important conditions impacting older patients, including agitation, certain types of cancer, delirium, dementia, diabetes, insomnia… Read & Research Alzheimer’s More

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A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer’s disease (AD) and, subsequently, other neurodegenerative diseases, i.e. frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Here we comprehensively assessed TREM2 rs75932628 for association with these diseases in a total Read & Research Alzheimer’s More

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Corrigendum"> Corrigendum

Posted April 30, 2015 By

In the abstract “Influence of rivastigmine transdermal on acetylcholine levels in patients with Alzheimer’s disease”, published on page P801 of the July 2014 supplement of Alzheimer’s & Dementia (10/4S), Gustavo Alves Andrade Dos Santos was accidently omitted as the first author. The correct author listing for this abstract should be: Read & Research Alzheimer’s More

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A new study from scientists at The Scripps Research Institute (TSRI) shows that nerve cells and blood vessels in the eye constantly “talk” to each other to maintain healthy blood flow and prevent… Read & Research Alzheimer’s More

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We evaluated the relationship between florbetapir-F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers. Read & Research Alzheimer’s More

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The cause of sporadic Alzheimer’s disease (AD) remains unclear. Given the growing evidence that protein aggregates can spread in a “prion-like” fashion, we reasoned that a small population of brain cells producing such “prion-like” particles due to a postzygotic acquired mutation would be sufficient to trigger the disease. Deep DNA Read & Research Alzheimer’s More

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Elderly people with HIV/AIDS have fewer lesions of Alzheimer’s disease in their brains than their HIV-negative peers, new findings presented at Touro College Research Day show. Read & Research Alzheimer’s More

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Every time you make a memory, somewhere in your brain a tiny filament reaches out from one neuron and forms an electrochemical connection to a neighboring neuron. Read & Research Alzheimer’s More

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New research highlights how nerves – whether harmed by disease or traumatic injury – start to die, a discovery that unveils novel targets for developing drugs to slow or halt peripheral neuropathies… Read & Research Alzheimer’s More

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Researchers have found that the proteins that control the progression of Alzheimer’s are linked in a pathway, and that drugs targeting this pathway may be a way of treating the disease, which affects… Read & Research Alzheimer’s More

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In fruit flies with Alzheimer’s-like memory abnormalities, researchers from Washington University in St. Louis found extra sleep restored their ability to make new memories. Read & Research Alzheimer’s More

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Neurodegenerative diseases are a major cause of cognitive impairment and can ultimately lead to dementia. Genome-wide association studies have uncovered many genetic variants conferring risk of neurodegenerative diseases, but their role in cognitive impairment remains unexplored. Read & Research Alzheimer’s More

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Sanders-Brown scientists identify molecule that reduces cognitive difficulties in animal modelsIt was once thought that effects of a mild head injury — dizziness, headaches, memory problems … Read & Research Alzheimer’s More

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People exposed to fine particulate matter long term may experience brain damage linked to age-related cognitive impairment and other neurological conditions, a new study finds. Read & Research Alzheimer’s More

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Article published in Future Science OA provides comprehensive review of research focused on inhibiting beta amyloid productionThere is both risk and reward in focusing Alzheimer’s disease… Read & Research Alzheimer’s More

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Patients with more challenging occupations may have longer survival after onset of frontotemporal dementia than those with less challenging jobs, a new study suggests. Read & Research Alzheimer’s More

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Researchers at the University of Pittsburgh School of Medicine will be part of a multicenter trial that will test for the first time whether a drug that treats brain plaques can prevent later… Read & Research Alzheimer’s More

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An international team of researchers, including investigators from the University of Mississippi Medical Center (UMMC), has identified a gene that underlies healthy information processing – a first… Read & Research Alzheimer’s More

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An international team of scientists, led by researchers at University of California, San Diego School of Medicine, have found genetic overlap between Alzheimer’s disease (AD) and two significant… Read & Research Alzheimer’s More

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Scanning our genetic code for variations linked to mental agility has helped to pinpoint a location on the human genome associated with efficient thinking. Read & Research Alzheimer’s More

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Dementia care for south Asian people could be improved after researchers from The University of Manchester adapted a commonly used tool for judging perceptions of the disease. Read & Research Alzheimer’s More

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Researchers have characterized three different brain imaging changes in individuals with Down syndrome, who are at very high risk for development of Alzheimer’s disease, even before the onset of… Read & Research Alzheimer’s More

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Meaningful activities experienced with others may reverse the normal brain shrinkage associated with the aging processInstead of shrinking as expected, as part of the normal aging process, the… Read & Research Alzheimer’s More

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Depression and diabetes each raised dementia risk on their own, but risk rose even more for people with both, in a large study of Alzheimer’s disease and vascular dementia. Read & Research Alzheimer’s More

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People who snore heavily or who have sleep apnea may experience earlier cognitive decline, a new study finds, but this decline could be reversed with CPAP. Read & Research Alzheimer’s More

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Using mice with human-like immune systems, a new study shows that certain immune cells in the brain chew up an important amino acid in the early stages of Alzheimer’s. Read & Research Alzheimer’s More

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Scientists from Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have have discovered how nerve cells adjust to low energy environments during the brain’s growth… Read & Research Alzheimer’s More

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Research study by the Mainz University Medical Center investigates the influence of low-frequency magnetic fields on neurodegenerative diseasesIn the case of animal model Alzheimer’s disease… Read & Research Alzheimer’s More

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While past research suggests obesity increases dementia risk, a new study finds this may not be the case. Instead, being underweight may increase risk of the condition. Read & Research Alzheimer’s More

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