Archive for June, 2015

Researchers find people who have a genetic predisposition for high blood pressure may be less likely to develop Alzheimer’s, possibly due to antihypertensive medication. Read & Research Alzheimer’s More

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Environmental factors and epigenetic mechanisms are believed to contribute to Alzheimer’s disease (AD). We previously documented that prenatal hypoxia aggravated the cognitive impairment and neuropathology in offspring mice. Here, we investigate the chronic hypoxia-induced epigenetic modifications in AD. Read & Research Alzheimer’s More

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The amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that… Read & Research Alzheimer’s More

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Research at the UK Sanders-Brown Center on Aging ‘will have important implications for the study of AD treatments in different patient populations’Researchers at the University of Kentucky’s… Read & Research Alzheimer’s More

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UAlberta scientists aim to understand how proteins convert from a normal structure to a diseased stateWorking towards the ultimate goal to develop therapeutics to treat diseases such as… Read & Research Alzheimer’s More

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Old beliefs upended as dementia research yields new locations for word and sentence comprehension Mapping brain is like ‘charting new galaxies in outer space’ Old map based on stroke… Read & Research Alzheimer’s More

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A new study suggests that errors on memory and thinking tests may signal Alzheimer’s up to 18 years before the disease can be diagnosed. Read & Research Alzheimer’s More

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A digital map of the ageing brain could aid the diagnosis of Alzheimer’s disease and other neurodegenerative disorders in older people, a study suggests. Read & Research Alzheimer’s More

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Analysis of health insurance data suggests preventive effectPatients with type 2 diabetes have a dysfunctional sugar metabolism because the essential hormone insulin does not work effectively. Read & Research Alzheimer’s More

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Scientists say they have a better understanding of why people with Alzheimer’s struggle to recognise and understand words – and their research has the potential to be developed into a test which… Read & Research Alzheimer’s More

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“The sheer scale and impact of neurological disease in Europe is underestimated and often overlooked. As a specialisation, neurology is under-resourced in many European countries. Read & Research Alzheimer’s More

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The thickness of the brain’s cerebral cortex could be a key to unlocking answers about intellectual development in youth with Down Syndrome. Read & Research Alzheimer’s More

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Several well-known neurodegenerative diseases, such as Lou Gehrig’s (ALS), Parkinson’s, Alzheimer’s, and Huntington’s disease, all result in part from a defect in autophagy – one way a cell removes… Read & Research Alzheimer’s More

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Neuropsychiatric symptoms (NPSs) are common in dementia and in predementia syndromes such as mild cognitive impairment (MCI). NPSs in MCI confer a greater risk for conversion to dementia in comparison to MCI patients without NPS. NPS in older adults with normal cognition also confers a greater risk of cognitive decline Read & Research Alzheimer’s More

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A new drug screening technology developed at the Harvard T.H. Chan School of Public Health has identified a new potential anti-diabetes compound–and a powerful way to quickly test whether other… Read & Research Alzheimer’s More

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The mild cognitive impairment (MCI) stage of Alzheimer’s disease (AD) may be optimal for clinical trials to test potential treatments for preventing or delaying decline to dementia. However, MCI is heterogeneous in that not all cases progress to dementia within the time frame of a trial and some may not Read & Research Alzheimer’s More

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A study in twins has discovered a single blood protein that could indicate in advance the development of mild cognitive impairment, a disorder associated with Alzheimer’s disease. Read & Research Alzheimer’s More

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Genetic variants that predict higher systolic blood pressure (SBP) are associated with a higher probability of taking antihypertensive medication and with decreased risk of Alzheimer disease (AD)… Read & Research Alzheimer’s More

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African-American (AA) individuals have a higher risk for late-onset Alzheimer’s disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the Alzheimer’s disease (AD)–related genetic variants originally discovered in EA cohorts are also risk variants in AA; Read & Research Alzheimer’s More

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Biomarkers monitoring synaptic degeneration/loss would be valuable for Alzheimer’s disease (AD) diagnosis. Postsynaptic protein neurogranin may be a promising cerebrospinal fluid (CSF) biomarker but has not yet been evaluated as a plasma biomarker. Read & Research Alzheimer’s More

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A new global review reveals that elder abuse–which includes psychological, physical, and sexual abuse; neglect; and financial exploitation–is common among community-dwelling older adults and is… Read & Research Alzheimer’s More

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The Aging Brain Care Medical Home, a novel population health management program implemented in the homes of older adults, achieves significant health improvement for individuals with depression and… Read & Research Alzheimer’s More

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Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting… Read & Research Alzheimer’s More

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Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting… Read & Research Alzheimer’s More

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The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Read & Research Alzheimer’s More

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The ability to identify individuals at increased genetic risk for Alzheimer’s disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. Read & Research Alzheimer’s More

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Researchers investigating kuru, a brain disease associated with cannibalism, have discovered a genetic mutation that provided mice with resistance to both the disease and CJD. Read & Research Alzheimer’s More

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New, ultra-high-field magnetic resonance images (MRI) of the brain by researchers at the University of Illinois at Chicago provide the most detailed images to date to show that while the brain… Read & Research Alzheimer’s More

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Medical guidance on how to care for elderly people with dementia following a hip fracture is ‘sadly lacking’ according to researchers at the University of East Anglia. Read & Research Alzheimer’s More

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The adenosine triphosphate-binding cassette transporter A1 (ABCA1) is a major cholesterol transporter highly expressed in the liver and brain. In the brain, ABCA1 lipidates apolipoprotein E (apoE), facilitates clearance of amyloid-β, and may be involved in maintenance of the blood-brain barrier via apoE-mediated pathways. Read & Research Alzheimer’s More

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