Researchers find people who have a genetic predisposition for high blood pressure may be less likely to develop Alzheimer’s, possibly due to antihypertensive medication. Read & Research Alzheimer’s More
Archive for June, 2015
High blood pressure linked to lower risk of Alzheimer's"> High blood pressure linked to lower risk of Alzheimer's
Posted June 29, 2015 ByChronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b"> Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b
Posted June 26, 2015 ByEnvironmental factors and epigenetic mechanisms are believed to contribute to Alzheimer’s disease (AD). We previously documented that prenatal hypoxia aggravated the cognitive impairment and neuropathology in offspring mice. Here, we investigate the chronic hypoxia-induced epigenetic modifications in AD. Read & Research Alzheimer’s More
Multiple pathways progressing to Alzheimer's disease"> Multiple pathways progressing to Alzheimer's disease
Posted June 26, 2015 ByThe amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that… Read & Research Alzheimer’s More
Alzheimer's disease works differently in patients with and without Down syndrome"> Alzheimer's disease works differently in patients with and without Down syndrome
Posted June 26, 2015 ByResearch at the UK Sanders-Brown Center on Aging ‘will have important implications for the study of AD treatments in different patient populations’Researchers at the University of Kentucky’s… Read & Research Alzheimer’s More
Solving the next step in the mystery of prions"> Solving the next step in the mystery of prions
Posted June 26, 2015 ByUAlberta scientists aim to understand how proteins convert from a normal structure to a diseased stateWorking towards the ultimate goal to develop therapeutics to treat diseases such as… Read & Research Alzheimer’s More
Redrawing language map of brain"> Redrawing language map of brain
Posted June 25, 2015 ByOld beliefs upended as dementia research yields new locations for word and sentence comprehension Mapping brain is like ‘charting new galaxies in outer space’ Old map based on stroke… Read & Research Alzheimer’s More
Low scores on memory and thinking tests may signal Alzheimer's earlier than thought"> Low scores on memory and thinking tests may signal Alzheimer's earlier than thought
Posted June 25, 2015 ByA new study suggests that errors on memory and thinking tests may signal Alzheimer’s up to 18 years before the disease can be diagnosed. Read & Research Alzheimer’s More
Atlas of older brains could help diagnosis of Alzheimer's disease"> Atlas of older brains could help diagnosis of Alzheimer's disease
Posted June 25, 2015 ByA digital map of the ageing brain could aid the diagnosis of Alzheimer’s disease and other neurodegenerative disorders in older people, a study suggests. Read & Research Alzheimer’s More
Diabetes medication reduces dementia risk"> Diabetes medication reduces dementia risk
Posted June 24, 2015 ByAnalysis of health insurance data suggests preventive effectPatients with type 2 diabetes have a dysfunctional sugar metabolism because the essential hormone insulin does not work effectively. Read & Research Alzheimer’s More
Word recognition 'could be the key' to early diagnosis of Alzheimer's"> Word recognition 'could be the key' to early diagnosis of Alzheimer's
Posted June 24, 2015 ByScientists say they have a better understanding of why people with Alzheimer’s struggle to recognise and understand words – and their research has the potential to be developed into a test which… Read & Research Alzheimer’s More
Neurological disease underestimated - experts call for more resources for research and patient care"> Neurological disease underestimated - experts call for more resources for research and patient care
Posted June 22, 2015 By“The sheer scale and impact of neurological disease in Europe is underestimated and often overlooked. As a specialisation, neurology is under-resourced in many European countries. Read & Research Alzheimer’s More
Thick cortex could be key in Down syndrome"> Thick cortex could be key in Down syndrome
Posted June 22, 2015 ByThe thickness of the brain’s cerebral cortex could be a key to unlocking answers about intellectual development in youth with Down Syndrome. Read & Research Alzheimer’s More
Protein 'comet tails' propel cell recycling process"> Protein 'comet tails' propel cell recycling process
Posted June 19, 2015 BySeveral well-known neurodegenerative diseases, such as Lou Gehrig’s (ALS), Parkinson’s, Alzheimer’s, and Huntington’s disease, all result in part from a defect in autophagy – one way a cell removes… Read & Research Alzheimer’s More
Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment"> Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment
Posted June 18, 2015 ByNeuropsychiatric symptoms (NPSs) are common in dementia and in predementia syndromes such as mild cognitive impairment (MCI). NPSs in MCI confer a greater risk for conversion to dementia in comparison to MCI patients without NPS. NPS in older adults with normal cognition also confers a greater risk of cognitive decline Read & Research Alzheimer’s More
New tool identifies novel compound targeting causes of type 2 diabetes"> New tool identifies novel compound targeting causes of type 2 diabetes
Posted June 18, 2015 ByA new drug screening technology developed at the Harvard T.H. Chan School of Public Health has identified a new potential anti-diabetes compound–and a powerful way to quickly test whether other… Read & Research Alzheimer’s More
Imaging-based enrichment criteria using deep-learning algorithms for efficient clinical trials in mild cognitive impairment"> Imaging-based enrichment criteria using deep-learning algorithms for efficient clinical trials in mild cognitive impairment
Posted June 17, 2015 ByThe mild cognitive impairment (MCI) stage of Alzheimer’s disease (AD) may be optimal for clinical trials to test potential treatments for preventing or delaying decline to dementia. However, MCI is heterogeneous in that not all cases progress to dementia within the time frame of a trial and some may not Read & Research Alzheimer’s More
Blood protein may indicate Alzheimer's disease risk"> Blood protein may indicate Alzheimer's disease risk
Posted June 17, 2015 ByA study in twins has discovered a single blood protein that could indicate in advance the development of mild cognitive impairment, a disorder associated with Alzheimer’s disease. Read & Research Alzheimer’s More
Genetically predicted higher BP linked to antihypertensive use and lower Alzheimer's risk"> Genetically predicted higher BP linked to antihypertensive use and lower Alzheimer's risk
Posted June 17, 2015 ByGenetic variants that predict higher systolic blood pressure (SBP) are associated with a higher probability of taking antihypertensive medication and with decreased risk of Alzheimer disease (AD)… Read & Research Alzheimer’s More
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk"> Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk
Posted June 16, 2015 ByAfrican-American (AA) individuals have a higher risk for late-onset Alzheimer’s disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the Alzheimer’s disease (AD)–related genetic variants originally discovered in EA cohorts are also risk variants in AA; Read & Research Alzheimer’s More
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease"> C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease
Posted June 16, 2015 ByBiomarkers monitoring synaptic degeneration/loss would be valuable for Alzheimer’s disease (AD) diagnosis. Postsynaptic protein neurogranin may be a promising cerebrospinal fluid (CSF) biomarker but has not yet been evaluated as a plasma biomarker. Read & Research Alzheimer’s More
Elder abuse is common around the world"> Elder abuse is common around the world
Posted June 16, 2015 ByA new global review reveals that elder abuse–which includes psychological, physical, and sexual abuse; neglect; and financial exploitation–is common among community-dwelling older adults and is… Read & Research Alzheimer’s More
Study finds novel population health management program yields major health improvement"> Study finds novel population health management program yields major health improvement
Posted June 16, 2015 ByThe Aging Brain Care Medical Home, a novel population health management program implemented in the homes of older adults, achieves significant health improvement for individuals with depression and… Read & Research Alzheimer’s More
Chemists find efficient, scalable way to synthesize potential brain-protecting compound"> Chemists find efficient, scalable way to synthesize potential brain-protecting compound
Posted June 16, 2015 ByChemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting… Read & Research Alzheimer’s More
TSRI chemists find efficient, scalable way to synthesize potential brain-protecting compound"> TSRI chemists find efficient, scalable way to synthesize potential brain-protecting compound
Posted June 16, 2015 ByChemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting… Read & Research Alzheimer’s More
Mediterranean-dietary approach to systolic hypertension diet intervention for neurodegenerative delay diet slows cognitive decline with aging"> Mediterranean-dietary approach to systolic hypertension diet intervention for neurodegenerative delay diet slows cognitive decline with aging
Posted June 15, 2015 ByThe Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Read & Research Alzheimer’s More
A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Aβ"> A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Aβ
Posted June 15, 2015 ByThe ability to identify individuals at increased genetic risk for Alzheimer’s disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. Read & Research Alzheimer’s More
'Cannibal disease' study reveals gene that produces CJD resistance"> 'Cannibal disease' study reveals gene that produces CJD resistance
Posted June 15, 2015 ByResearchers investigating kuru, a brain disease associated with cannibalism, have discovered a genetic mutation that provided mice with resistance to both the disease and CJD. Read & Research Alzheimer’s More
Cell density remains constant as brain shrinks with age"> Cell density remains constant as brain shrinks with age
Posted June 15, 2015 ByNew, ultra-high-field magnetic resonance images (MRI) of the brain by researchers at the University of Illinois at Chicago provide the most detailed images to date to show that while the brain… Read & Research Alzheimer’s More
Lack of evidence on how to care for hip fracture patients with dementia"> Lack of evidence on how to care for hip fracture patients with dementia
Posted June 15, 2015 ByMedical guidance on how to care for elderly people with dementia following a hip fracture is ‘sadly lacking’ according to researchers at the University of East Anglia. Read & Research Alzheimer’s More
Loss-of-function mutation in and risk of Alzheimer and cerebrovascular disease"> Loss-of-function mutation in and risk of Alzheimer and cerebrovascular disease
Posted June 13, 2015 ByThe adenosine triphosphate-binding cassette transporter A1 (ABCA1) is a major cholesterol transporter highly expressed in the liver and brain. In the brain, ABCA1 lipidates apolipoprotein E (apoE), facilitates clearance of amyloid-β, and may be involved in maintenance of the blood-brain barrier via apoE-mediated pathways. Read & Research Alzheimer’s More