Archive for July, 2015

EXPEDITION and EXPEDITION2 were identically designed placebo-controlled phase 3 studies assessing effects of solanezumab, an antiamyloid monoclonal antibody binding soluble amyloid-β peptide, on cognitive and functional decline over 80 weeks in patients with mild-to-moderate Alzheimer’s disease (AD). Primary findings for both studies have been published. Read & Research Alzheimer’s More

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Copper hypothesis questionedResearchers at the University of Melbourne have discovered that a protein involved in the progression of Alzheimer’s disease also has properties that could be helpful… Read & Research Alzheimer’s More

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UM Rosenstiel School scientists show underlying mechanism that control age-related memory lossThis is Aplysia californica. Credit: Michael Schmale, Ph.D. Read & Research Alzheimer’s More

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With the growing number of people with Alzheimer’s disease, understanding their care is vital for doctors. Read & Research Alzheimer’s More

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Findings may result in new drugs to treat the devastating diseaseFor the first time, UCLA researchers have shown that a natural protein fragment produced in the brain can act as an inhibitor of a… Read & Research Alzheimer’s More

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Increasing coffee consumption over time to more than one cup daily may raise the risk of mild cognitive impairment, while reducing it may lower risk, according to new research. Read & Research Alzheimer’s More

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Study of post-surgical patients shows elevated levels of inflammatory cytokines are strongly associated with deliriumDelirium is an acute state of confusion that often affects older adults… Read & Research Alzheimer’s More

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Diseases like Alzheimer’s are caused when proteins aggregate and clump together. Read & Research Alzheimer’s More

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Although genetic Aβ variants cause early-onset Alzheimer’s disease, literature reports on Aβ properties are heterogeneous, obscuring molecular mechanisms, as illustrated by recent failures of Aβ-level targeting trials. Thus, we combined available data on Aβ levels and ratios, aggregation propensities, toxicities, and patient data for Aβ variants and correlated these data Read & Research Alzheimer’s More

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To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and 2001. Read & Research Alzheimer’s More

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Studies presented at the Alzheimer’s Association International Conference suggest that physical exercise could both protect the brain and alleviate symptoms of Alzheimer’s disease. Read & Research Alzheimer’s More

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Anavex Life Sciences Corp. has announced initial positive cognitive data for ANAVEX 2-73, the Company’s lead investigational oral treatment for Alzheimer’s targeting sigma-1 and muscarinic… Read & Research Alzheimer’s More

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Today Biogen has announced new results from a prespecified interim analysis of PRIME, the Phase 1b placebo-controlled study of aducanumab (BIIB037) in patients with prodromal or mild Alzheimer’s… Read & Research Alzheimer’s More

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As the 2015 Alzheimer’s Association International Conference draws to a close, we look at some of the studies leading us closer to prevention and treatment strategies for dementia. Read & Research Alzheimer’s More

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In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred significantly more often in individuals diagnosed… Read & Research Alzheimer’s More

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The first ever Alzheimer’s disease clinical trial to use delayed-start methodology has found that patients with a mild form of the disease benefit from beginning treatment early. Read & Research Alzheimer’s More

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Discovery by Tel Aviv University, Antwerp University researchers of the mutations of a neuroprotective protein finds expression in the story of a 7-year-old patientChildren born with… Read & Research Alzheimer’s More

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Findings may influence strategies for treatmentA recent study conducted at Nathan S. Read & Research Alzheimer’s More

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Given the recent acknowledgement of the complex mixed pathologies that contribute to the clinical expression of dementia, various cohort studies have aimed to examine Alzheimer’s disease and cerebrovascular disease as comorbid pathologies, with neuroimaging playing a central role in these studies. Using white matter hyperintensities (WMH) as a biomarker of Read & Research Alzheimer’s More

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Bournemouth University researcher to present results at American Alzheimer’s Association International ConferenceUnexplained weight loss is often seen in people with dementia, which can lead… Read & Research Alzheimer’s More

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A new study finds low physical activity and high TV viewing between the ages of 18 and 30 may be associated with poorer cognitive function later in life. Read & Research Alzheimer’s More

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Cerebrospinal fluid (CSF) amyloid-β 1–42 (Aβ42) is an important biomarker for Alzheimer’s disease, both in diagnostics and to monitor disease-modifying therapies. However, there is a great need for standardization of methods used for quantification. To overcome problems associated with immunoassays, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as a critical Read & Research Alzheimer’s More

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The results of a new study show promise for a simple saliva test that could predict a person’s risk of developing Alzheimer’s disease. Read & Research Alzheimer’s More

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Study explains how output of single neurons can predict behavior on perceptual testsBy analyzing the signals of individual neurons, neuroscientists have deciphered the code the brain uses to… Read & Research Alzheimer’s More

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Certain patients with type 2 diabetes (T2D) may have specific genetic risk factors that put them at higher risk for developing Alzheimer’s disease (AD), according to a study conducted at the Icahn… Read & Research Alzheimer’s More

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Traditional vaccination against infectious diseases relies on generation of cellular and humoral immune responses that act to protect the host from overt disease even though they do not induce sterilizing immunity. More recently, attempts have been made with mixed success to generate therapeutic vaccines against a wide range of noninfectious Read & Research Alzheimer’s More

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The Mediterranean diet (MeDi) has been related to a lower risk of Alzheimer’s disease; yet, the underlying mechanisms are unknown. We hypothesized that protection against neurodegeneration would translate into higher gray matter volumes, whereas a specific association with preserved white matter microstructure would suggest alternative mechanisms (e.g., vascular pathways). Read & Research Alzheimer’s More

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Researchers found variations between African-American and European-American patients in how Alzheimer’s disease makes changes in the brain. Read & Research Alzheimer’s More

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Older adults can improve their focus and attention by raising their fitness level, new research showsNew research conducted at the University of Kansas Medical Center indicates that older adults… Read & Research Alzheimer’s More

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A University of Toronto research team has discovered new details about a key gene involved in ALS, perhaps humanity’s most puzzling, intractable disease. Read & Research Alzheimer’s More

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