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Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

Recently, quantitative metabolomics identified a panel of 10 plasma lipids that were highly predictive of conversion to Alzheimer’s disease (AD) in cognitively normal older individuals (n = 28, area under the curve [AUC] = 0.92, sensitivity/specificity of 90%/90%). We failed to replicate these findings in a substantially larger study from two independent cohorts—the Baltimore Read & Research Alzheimer’s More

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