Archive for April, 2016

The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent. Read & Research Alzheimer’s More

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Neurofibrillary pathology of abnormally hyperphosphorylated tau (P-tau) is a hallmark of Alzheimer’s disease (AD) and other tauopathies. Tau pathology can be experimentally induced and propagated. However, what induces the prion-like transmission character to tau and produces morphologically distinct tau lesions remains elusive. Read & Research Alzheimer’s More

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A new study finds that people with the chronic inflammatory skin condition rosacea appear to be at slightly higher risk of developing dementia – particularly Alzheimer’s disease. Read & Research Alzheimer’s More

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Mice modeled with Alzheimer’s disease undergoing micro-needle procedure had reductions in beta-amyloid plaques stimulation of hippocampus also appears to aid in regaining learning abilities. Read & Research Alzheimer’s More

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Amyloid-beta (Aβ) peptide oligomerization plays a central role in the pathogenesis of Alzheimer’s disease (AD), and Aβ oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms leading to the pathologic accumulation of oligomers are unclear, and the exact structural composition of oligomers Read & Research Alzheimer’s More

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Mexican researchers developed a nanogel that enables the growth of new neurons. Read & Research Alzheimer’s More

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O-GlcNAcylation is the posttranslational modification of intracellular proteins by O-linked β-N-acetylglucosamine (O-GlcNAc). The discovery of O-GlcNAc modification of tau and its impact on tau phosphorylation has attracted recent research interest in O-GlcNAc studies in the Alzheimer’s disease (AD) field. Modification of proteins by O-GlcNAc occurs extensively in the brain. The Read & Research Alzheimer’s More

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Accumulation of hyperphosphorylated tau and the disruption of microtubules are correlated with synaptic loss and pathology of Alzheimer’s disease (AD). Impaired cognitive function and pathology of AD is correlated with this lesion. This review looks at the mechanism of neurodegeneration, the prion-like behavior of tau in its interaction with normal Read & Research Alzheimer’s More

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New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer’s, according to… Read & Research Alzheimer’s More

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Pilot study examines cognition, depressive symptoms and vascular factors among southwest tribal elders. Read & Research Alzheimer’s More

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University of Florida Health researchers have developed a unique mouse model that will allow researchers around the world to better study the genetic origins and potential treatments for a… Read & Research Alzheimer’s More

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UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage. Read & Research Alzheimer’s More

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By analyzing the genes of elderly adults completely free of chronic disease and illness, researchers have uncovered genetic variants that may boost healthy aging. Read & Research Alzheimer’s More

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Mild-AD subjects without significant Aβ pathology represent a confounding finding for clinical trials because they may not progress clinically on the expected trajectory, adding variance into analyses where slowing of progression is being measured. Read & Research Alzheimer’s More

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For years, neuroscientists have puzzled over how two abnormal proteins, called amyloid and tau, accumulate in the brain and damage it to cause Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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Traumatic brain injury (TBI), a leading cause of death and disability, has become so common in recent times that it has been called a “silent epidemic. Read & Research Alzheimer’s More

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Role of adaptor protein CD2AP in neuron sprouting discovered by UofL researchers could lead to therapies for Alzheimer’s disease, stroke recovery and spinal cord injury. Read & Research Alzheimer’s More

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In Alzheimer’s disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing brain networks at the macroscale before Aβ deposition. The latter can be detected noninvasively, in vivo, using resting-state functional MRI (rsfMRI), a technique used to assess brain functional connectivity (FC). Read & Research Alzheimer’s More

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A new study from the Indiana University Center for Aging Research and the Regenstrief Institute has found that almost half of all long-stay nursing home residents experience at least one transfer… Read & Research Alzheimer’s More

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In a study published in the Journal of the American Geriatrics Society, researchers examined whether or not antipsychotic drugs, which are sometimes used to prevent or treat delirium, are… Read & Research Alzheimer’s More

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We studied the mortality risk of long term and new antipsychotic drug use in Alzheimer’s disease (AD) patients in Japan to determine improved treatment protocols. Read & Research Alzheimer’s More

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Memories formed in one part of the brain are replayed and transferred to a different area of the brain during rest, according to a new UCL study in rats. Read & Research Alzheimer’s More

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The UK has seen a 20% fall in the incidence of dementia over the past two decades, according to new research from England, led by the University of Cambridge, leading to an estimated 40,000 fewer… Read & Research Alzheimer’s More

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The first detailed study of relationship between plasma Aβ levels, cognitive function and the measures studying the size of brain, which shrinks with Alzheimer’s disease. Read & Research Alzheimer’s More

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Rice University theorists model complex interactions that allow for long-term memory. Read & Research Alzheimer’s More

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We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia. Read & Research Alzheimer’s More

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Transition to bathing or dressing disability is a milestone in the evolution of dementia. We examined the transition to disability in these specific activities and considered death to be a competitive event and age and sex to be prognostic factors. Read & Research Alzheimer’s More

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Georgetown University researchers are reporting the first case of Alzheimer’s disease diagnosed in an HIV-positive individual. Read & Research Alzheimer’s More

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Compared to Caucasians, African Americans (AAs) have higher dementia prevalence, different genetic markers, and higher vascular risk factors. However, pathologic underpinnings are unknown. Read & Research Alzheimer’s More

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While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes… Read & Research Alzheimer’s More

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