Archive for July, 2016

Researchers complete the first ever phase III trial of a drug that reduces formation of tau ‘tangles’ in the brain, offering hope to Alzheimer’s patients. Read & Research Alzheimer’s More

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Neuroscientists at Seattle Children’s Research Institute have discovered an area of the brain that plays a key role in breathing. Read & Research Alzheimer’s More

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A gene that protects the brain from the harmful build-up of amyloid-beta, one of the causative proteins implicated in Alzheimer’s disease, has been identified as a new target for therapy by NeuRA… Read & Research Alzheimer’s More

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Resveratrol – a chemical found in certain plant-based foods – helps researchers understand more about the damaging immune response in Alzheimer’s brains. Read & Research Alzheimer’s More

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Results challenge the stereotype of depression, denial and despair post-diagnosis. Read & Research Alzheimer’s More

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A randomized controlled study has evaluated the effects of two treatments for mild cognitive impairment. Read & Research Alzheimer’s More

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The first case of Alzheimer’s disease diagnosed in an HIV-positive individual will be presented in a poster session at the Alzheimer’s Association International Conference 2016 in Toronto July 27. Read & Research Alzheimer’s More

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The accumulation of β-Amyloid (Aβ) and tau proteins in the brain is hallmark pathology for Alzheimer disease. Read & Research Alzheimer’s More

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Researchers have created a 38-point checklist that they say could identify changes in personality and behavior that may be an early sign of Alzheimer’s. Read & Research Alzheimer’s More

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The study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as… Read & Research Alzheimer’s More

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A new protein which will help scientists to understand why nerve cells die in people with Alzheimer’s disease has been designed in a University of Sussex laboratory. Read & Research Alzheimer’s More

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The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Read & Research Alzheimer’s More

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Tau protein is known to spread from neuron to neuron in Alzheimer’s. Now, a new study shows at least one way is via the extracellular space between cells. Read & Research Alzheimer’s More

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Scientists explain why larger brains are more susceptible to mental illness.The larger the brain, the weaker the long-distance cortical connections. Read & Research Alzheimer’s More

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Given that Alzheimer’s pathology develops silently over decades in Down syndrome (DS), prognostic biomarkers of dementia are a major need. Read & Research Alzheimer’s More

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Treating mice with antibiotics decreases the level of plaques that cause Alzheimer’s disease and elevates microglial cell inflammation in the brain. Read & Research Alzheimer’s More

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People with a variant copy of the TREM2 gene have an increased risk of developing Alzheimer’s disease, but researchers are only beginning to understand why. Read & Research Alzheimer’s More

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UCI group develops test to measure changes in emotional recall over time.People who selectively recalled positive information over neutral and negative information performed worse on memory… Read & Research Alzheimer’s More

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We evaluated the effect of cerebral amyloid-β (Aβ) deposition in cognitively normal (CN) seniors on regional metabolism of specific brain regions known to be affected by p-tau deposition. Read & Research Alzheimer’s More

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A new vaccine combination has proven successful in mouse models of Alzheimer’s, new study reveals, and it could be tested in humans within 3-5 years. Read & Research Alzheimer’s More

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Tau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer’s disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals. Read & Research Alzheimer’s More

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White matter hyperintensities (WMHs) increase the risk of Alzheimer’s disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated. Read & Research Alzheimer’s More

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If you had heart disease risk factors, such as high blood pressure, before your first stroke, your risk of suffering subsequent strokes and dementia up to five years later may be higher, according… Read & Research Alzheimer’s More

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Scientists at the Montreal Neurological Institute and Hospital have used a powerful tool to better understand the progression of late-onset Alzheimer’s disease (LOAD), identifying its first… Read & Research Alzheimer’s More

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Rockefeller University researchers have used a recently-developed imaging technique that makes tissue transparent to visualize brain tissue from deceased patients with Alzheimer’s disease, exposing… Read & Research Alzheimer’s More

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder that causes a range of motor and non-motor symptoms. Read & Research Alzheimer’s More

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Can estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Read & Research Alzheimer’s More

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Effects of the apolipoprotein E gene, with the greatest influence on the risk of developing late-onset Alzheimer’s disease, may be present in childhood. Read & Research Alzheimer’s More

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Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer’s disease (AD), mainly using observational data and with little consideration of clinical relevance. Read & Research Alzheimer’s More

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TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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