Researchers complete the first ever phase III trial of a drug that reduces formation of tau ‘tangles’ in the brain, offering hope to Alzheimer’s patients. Read & Research Alzheimer’s More
Archive for July, 2016
Alzheimer's drug shows promise for patients in phase III trial"> Alzheimer's drug shows promise for patients in phase III trial
Posted July 29, 2016 ByResearchers discover area of brain that controls breathing"> Researchers discover area of brain that controls breathing
Posted July 28, 2016 ByNeuroscientists at Seattle Children’s Research Institute have discovered an area of the brain that plays a key role in breathing. Read & Research Alzheimer’s More
Gene provides new target for Alzheimer's disease treatment"> Gene provides new target for Alzheimer's disease treatment
Posted July 28, 2016 ByA gene that protects the brain from the harmful build-up of amyloid-beta, one of the causative proteins implicated in Alzheimer’s disease, has been identified as a new target for therapy by NeuRA… Read & Research Alzheimer’s More
Resveratrol study offers new insight into Alzheimer's"> Resveratrol study offers new insight into Alzheimer's
Posted July 28, 2016 ByResveratrol – a chemical found in certain plant-based foods – helps researchers understand more about the damaging immune response in Alzheimer’s brains. Read & Research Alzheimer’s More
Does a dementia diagnosis have a silver lining? Study suggests it can"> Does a dementia diagnosis have a silver lining? Study suggests it can
Posted July 27, 2016 ByResults challenge the stereotype of depression, denial and despair post-diagnosis. Read & Research Alzheimer’s More
What can be done when mild cognitive impairment occurs?"> What can be done when mild cognitive impairment occurs?
Posted July 27, 2016 ByA randomized controlled study has evaluated the effects of two treatments for mild cognitive impairment. Read & Research Alzheimer’s More
First diagnosed case of Alzheimer's disease in HIV-positive individual presented at AAIC"> First diagnosed case of Alzheimer's disease in HIV-positive individual presented at AAIC
Posted July 26, 2016 ByThe first case of Alzheimer’s disease diagnosed in an HIV-positive individual will be presented in a poster session at the Alzheimer’s Association International Conference 2016 in Toronto July 27. Read & Research Alzheimer’s More
Using tau imaging as diagnostic marker for Alzheimer disease"> Using tau imaging as diagnostic marker for Alzheimer disease
Posted July 26, 2016 ByThe accumulation of β-Amyloid (Aβ) and tau proteins in the brain is hallmark pathology for Alzheimer disease. Read & Research Alzheimer’s More
Personality, behavioral changes may signal Alzheimer's"> Personality, behavioral changes may signal Alzheimer's
Posted July 25, 2016 ByResearchers have created a 38-point checklist that they say could identify changes in personality and behavior that may be an early sign of Alzheimer’s. Read & Research Alzheimer’s More
Researchers discover the machinery that neurons use to form and maintain their neuronal extensions"> Researchers discover the machinery that neurons use to form and maintain their neuronal extensions
Posted July 25, 2016 ByThe study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as… Read & Research Alzheimer’s More
Designer protein gives new hope to scientists studying Alzheimer's disease"> Designer protein gives new hope to scientists studying Alzheimer's disease
Posted July 25, 2016 ByA new protein which will help scientists to understand why nerve cells die in people with Alzheimer’s disease has been designed in a University of Sussex laboratory. Read & Research Alzheimer’s More
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness"> Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Posted July 24, 2016 ByThe Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Read & Research Alzheimer’s More
Alzheimer's protein spreads through space between brain cells"> Alzheimer's protein spreads through space between brain cells
Posted July 22, 2016 ByTau protein is known to spread from neuron to neuron in Alzheimer’s. Now, a new study shows at least one way is via the extracellular space between cells. Read & Research Alzheimer’s More
Mental illness: Could brain size be a risk factor?"> Mental illness: Could brain size be a risk factor?
Posted July 22, 2016 ByScientists explain why larger brains are more susceptible to mental illness.The larger the brain, the weaker the long-distance cortical connections. Read & Research Alzheimer’s More
An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation"> An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation
Posted July 21, 2016 ByGiven that Alzheimer’s pathology develops silently over decades in Down syndrome (DS), prognostic biomarkers of dementia are a major need. Read & Research Alzheimer’s More
Could antibiotics reduce levels of Alzheimer's-causing plaques?"> Could antibiotics reduce levels of Alzheimer's-causing plaques?
Posted July 21, 2016 ByTreating mice with antibiotics decreases the level of plaques that cause Alzheimer’s disease and elevates microglial cell inflammation in the brain. Read & Research Alzheimer’s More
Three Alzheimer's genetic risk factors linked to immune cell dysfunction"> Three Alzheimer's genetic risk factors linked to immune cell dysfunction
Posted July 21, 2016 ByPeople with a variant copy of the TREM2 gene have an increased risk of developing Alzheimer’s disease, but researchers are only beginning to understand why. Read & Research Alzheimer’s More
Selective retention of positive information may be marker for elderly memory loss"> Selective retention of positive information may be marker for elderly memory loss
Posted July 21, 2016 ByUCI group develops test to measure changes in emotional recall over time.People who selectively recalled positive information over neutral and negative information performed worse on memory… Read & Research Alzheimer’s More
The effect of β-amyloid positivity on cerebral metabolism in cognitively normal seniors"> The effect of β-amyloid positivity on cerebral metabolism in cognitively normal seniors
Posted July 18, 2016 ByWe evaluated the effect of cerebral amyloid-β (Aβ) deposition in cognitively normal (CN) seniors on regional metabolism of specific brain regions known to be affected by p-tau deposition. Read & Research Alzheimer’s More
Alzheimer's vaccine steps closer with new study"> Alzheimer's vaccine steps closer with new study
Posted July 18, 2016 ByA new vaccine combination has proven successful in mouse models of Alzheimer’s, new study reveals, and it could be tested in humans within 3-5 years. Read & Research Alzheimer’s More
Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort"> Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort
Posted July 16, 2016 ByTau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer’s disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals. Read & Research Alzheimer’s More
Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease"> Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease
Posted July 15, 2016 ByWhite matter hyperintensities (WMHs) increase the risk of Alzheimer’s disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated. Read & Research Alzheimer’s More
Pre-stroke risk factors influence long-term future stroke, dementia risk"> Pre-stroke risk factors influence long-term future stroke, dementia risk
Posted July 15, 2016 ByIf you had heart disease risk factors, such as high blood pressure, before your first stroke, your risk of suffering subsequent strokes and dementia up to five years later may be higher, according… Read & Research Alzheimer’s More
'Big Data' study discovers earliest sign of Alzheimer's development"> 'Big Data' study discovers earliest sign of Alzheimer's development
Posted July 15, 2016 ByScientists at the Montreal Neurological Institute and Hospital have used a powerful tool to better understand the progression of late-onset Alzheimer’s disease (LOAD), identifying its first… Read & Research Alzheimer’s More
3-D imaging reveals unexpected arrangement of plaques in Alzheimer's-afflicted brains"> 3-D imaging reveals unexpected arrangement of plaques in Alzheimer's-afflicted brains
Posted July 15, 2016 ByRockefeller University researchers have used a recently-developed imaging technique that makes tissue transparent to visualize brain tissue from deceased patients with Alzheimer’s disease, exposing… Read & Research Alzheimer’s More
Leukemia drug shows early promise for treating Parkinson's disease and dementia"> Leukemia drug shows early promise for treating Parkinson's disease and dementia
Posted July 14, 2016 ByParkinson’s disease (PD) is the second most common neurodegenerative disorder that causes a range of motor and non-motor symptoms. Read & Research Alzheimer’s More
Estrogen patch in newly postmenopausal women may reduce Alzheimer's risk"> Estrogen patch in newly postmenopausal women may reduce Alzheimer's risk
Posted July 14, 2016 ByCan estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Read & Research Alzheimer’s More
Side effects of Alzheimer's gene visible in child brain development"> Side effects of Alzheimer's gene visible in child brain development
Posted July 14, 2016 ByEffects of the apolipoprotein E gene, with the greatest influence on the risk of developing late-onset Alzheimer’s disease, may be present in childhood. Read & Research Alzheimer’s More
Evaluating the clinical relevance of a cognitive composite outcome measure: An analysis of 1414 participants from the 5-year GuidAge Alzheimer's prevention trial"> Evaluating the clinical relevance of a cognitive composite outcome measure: An analysis of 1414 participants from the 5-year GuidAge Alzheimer's prevention trial
Posted July 13, 2016 ByComposite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer’s disease (AD), mainly using observational data and with little consideration of clinical relevance. Read & Research Alzheimer’s More
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease"> Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Posted July 13, 2016 ByTREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer’s disease (AD). Read & Research Alzheimer’s More