Archive for September, 2016

The proportion of people dying with a recorded dementia diagnosis has more than doubled since 2001. Read & Research Alzheimer’s More

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Individuals with amnestic mild cognitive impairment (aMCI) are at elevated risk of developing Alzheimer’s disease (AD) dementia. Read & Research Alzheimer’s More

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Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and Read & Research Alzheimer’s More

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We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD). Read & Research Alzheimer’s More

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More than 5 million Americans are living with Alzheimer’s disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be Read & Research Alzheimer’s More

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A pathological pathway leading from soluble to insoluble and filamentous Tau underlies human tauopathies. This ordered assembly causes disease and is the gain-of-toxic function. It involves the transition from an intrinsically disordered monomer to a highly structured filament. Based on recent findings, one can divide the ordered assembly into propagation Read & Research Alzheimer’s More

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Work in the past 10 years has greatly expanded our understanding of Alzheimer’s disease (AD) genetics, with more than 20 susceptibility genetic loci discovered in large genome-wide association and sequencing studies. The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is funded by National Institute on Aging to serve Read & Research Alzheimer’s More

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A new study of classical Chinese medical texts identifies references to age-related memory impairment similar to modern-day Alzheimer’s disease, and to several plant-based ingredients used… Read & Research Alzheimer’s More

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A new study finds that amyloid beta – a protein involved in Alzheimer’s disease – changes into a long, flat sheet before it enters brain cells. Read & Research Alzheimer’s More

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There has been no sustained reduction in the prescription of antipsychotics to UK dementia patients, despite government guidance, according to a report published in the medical journal BMJ Open. Read & Research Alzheimer’s More

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Some older adults do not experience a decline in memory ability with age. Researchers reveal the youthful mechanism behind the brain of the ‘super ager.’ Read & Research Alzheimer’s More

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A new study of 3050 twins finds moderately vigorous physical activity – i.e., more strenuous than walking – to be associated with better cognition in a 25-year follow-up. Read & Research Alzheimer’s More

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New research suggests that Alzheimer’s disease may trigger increased expression of an enzyme called lysozyme, which attempts to counteract amyloid build-up in the brain. Read & Research Alzheimer’s More

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Maintaining cognitive functioning—“staying mentally sharp”—was identified as the number one health priority for 87% of American retirees [1]. In June 2016, the Alzheimer’s Drug Discovery Foundation and the New York Academy of Sciences convened leading experts to discuss the prevalent yet underrecognized risks of surgery to cognitive function. Read & Research Alzheimer’s More

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A group of scientists have found that a single molecule from a bacterial cell wall component can lead to the unusual behaviour of 100 million clotting molecules in blood, which may be a major… Read & Research Alzheimer’s More

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Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to Read & Research Alzheimer’s More

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To identify incidence and prevalence of dementia in racial and ethnic populations in the United States. Read & Research Alzheimer’s More

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Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. Read & Research Alzheimer’s More

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A research team, led by Cardiff University, has made a significant step towards the development of a simple blood test to predict the onset of Alzheimer’s disease. Read & Research Alzheimer’s More

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Aducanumab, an antibody developed by the University of Zurich, has been shown to trigger a meaningful reduction of harmful beta-amyloid plaques in patients with early-stage Alzheimer’s disease. Read & Research Alzheimer’s More

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