Archive for October, 2016

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be afflicted, and how quickly the… Read & Research Alzheimer’s More

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More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. Read & Research Alzheimer’s More

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This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1–42, tau, and phosphorylated tau in the diagnostic evaluation of patients with mild cognitive impairment (MCI). The recommendations were developed by a multidisciplinary working group and based Read & Research Alzheimer’s More

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The Colombian Alzheimer’s Prevention Initiative (API) Registry is a collaborative project among the Neurosciences Group of Antioquia, the Banner Alzheimer’s Institute, and Genentech. The main goal is to provide a source of interested research participants and data to support the API-Colombia Autosomal Dominant Alzheimer’s Disease Trial and help find treatments Read & Research Alzheimer’s More

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This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1–42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence Read & Research Alzheimer’s More

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Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-brain barrier (BBB) leakage may be important in SVD-induced brain damage. Read & Research Alzheimer’s More

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Results published in The Journal of the Prevention of Alzheimer’s Disease (JPAD) describe analyses of Phase 3 data for the investigational amyloid-targeted drug, tramiprosate, in patients with Mild… Read & Research Alzheimer’s More

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An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a… Read & Research Alzheimer’s More

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Hospital admission rates are 55 per cent higher in some areas than in others because of a greater prevalence of conditions such as diabetes, alcoholism, dementia and socioeconomic deprivation. Read & Research Alzheimer’s More

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We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and AD subjects. Read & Research Alzheimer’s More

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As we age, the outer layer of brain tissue – the cerebral cortex – loses tension, and this is even more pronounced in patients with Alzheimer’s. Read & Research Alzheimer’s More

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New research finds gradually increasing muscle resistance improves brain function in elderly people. This might delay the onset of dementia. Read & Research Alzheimer’s More

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High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. Read & Research Alzheimer’s More

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Elderly people who were uprooted from damaged or destroyed homes and who lost touch with their neighbors after the 2011 tsunami in Japan were more likely to experience increased symptoms of… Read & Research Alzheimer’s More

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New Alzheimer’s treatment could be delivered as nasal spray.Researchers have developed a novel treatment that could block the development of Alzheimer’s disease using microscopic droplets of fat… Read & Research Alzheimer’s More

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A rare variant in the TM2D3 gene linked to increased risk and earlier onset of Alzheimer’s disease. Read & Research Alzheimer’s More

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Study suggests zebrafish might teach us how to tackle Alzheimer’s disease: Patients with Alzheimer’s or other neurodegenerative diseases progressively loose neurons yet cannot build new ones. Read & Research Alzheimer’s More

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Regular exercise has been found to improve overall thinking skills and cardiovascular capacity in people with vascular cognitive impairment. Read & Research Alzheimer’s More

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African Americans’ (AAs) late-onset Alzheimer’s disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power. Read & Research Alzheimer’s More

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Cardiac function is a key player in maintaining energy homeostasis in the brain. Heart failure is closely related to higher risk of neurocognitive disorders. Recent evidence shows that this relationship might not be limited to patients with advanced heart failure, and even suboptimal cardiac functioning is associated with accelerated brain Read & Research Alzheimer’s More

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University of Adelaide researchers have developed a world-first optical sensor that can detect vitamin B12 in diluted human blood – a first step towards a low-cost, portable, broadscale vitamin B12… Read & Research Alzheimer’s More

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Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid-β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical Read & Research Alzheimer’s More

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Alzheimer’s and Parkinson’s diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two. Read & Research Alzheimer’s More

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Findings confirm mutation-caused problem but also reveal a new therapeutic target. Read & Research Alzheimer’s More

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The inhibition of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer’s disease (AD). We previously reported an age-related increase of tau protein in the cerebrospinal fluid (CSF) of Aβ precursor protein (APP) transgenic mice. Read & Research Alzheimer’s More

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NIH-funded mouse study identifies a possible therapeutic target for a family of disorders. Read & Research Alzheimer’s More

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Men treated with androgen deprivation therapy – a hormone therapy – for prostate cancer may be more than twice as likely to develop dementia, study finds. Read & Research Alzheimer’s More

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Men treated with androgen deprivation therapy – a hormone therapy – for prostate cancer may be more than twice as likely to develop dementia, study finds. Read & Research Alzheimer’s More

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Experts have created a shortlist of environmental factors that may contribute to our risk of developing dementia. Read & Research Alzheimer’s More

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Corticobasal syndrome (CBS) resulting from genetic Alzheimer’s disease (AD) has been described only once. Whether familial CBS-AD is a distinct clinical entity with its own imaging signature remains unknown. Read & Research Alzheimer’s More

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