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Peril beyond the winner's curse—A small sample size is the bane of biomarker discovery

We thank Mapstone et al. for their comments on our failure to replicate their index findings on plasma metabolite biomarkers of incident Alzheimer disease (AD) [1]. They raise three main concerns with our study [2] which they suggest precludes comparison with their earlier report. We respond to each of these in Read & Research Alzheimer’s More

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