Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of AD

Alzheimer disease (AD) is a neurodegenerative disease associated with the abnormal accumulation of amyloid β (Aβ) and microtubule-associated protein tau (tau). Although the mechanisms through which abnormal accumulation of proteins leads to neuronal vulnerability are still under investigation, intracellular calcium homeostasis is dysregulated and has been implicated in the neurobiology Read & Research Alzheimer’s More

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