Archive for February, 2017

What is frontotemporal dementia and what are the different types of frontotemporal dementia? What are the possible causes and how is it diagnosed? Read & Research Alzheimer’s More

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Cells behave differently when removed from their environments, just as cells that develop in cultures do not behave like cells in living creatures. Read & Research Alzheimer’s More

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It is hypothesized that retrotransposons have played a fundamental role in primate evolution and that enhanced neurologic retrotransposon activity in humans may underlie the origin of higher cognitive function. As a potential consequence of this enhanced activity, it is likely that neurons are susceptible to deleterious retrotransposon pathways that can Read & Research Alzheimer’s More

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Sensitive detection of cognitive decline over the course of preclinical Alzheimer’s disease is critical as the field moves toward secondary prevention trials. Read & Research Alzheimer’s More

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We sought to determine whether a systems biology approach may identify novel late-onset Alzheimer’s disease (LOAD) loci. Read & Research Alzheimer’s More

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The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the Read & Research Alzheimer’s More

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Eating five portions of fruits and vegetables daily – in line with current recommendations – may reduce older adults’ risk of dementia, study finds. Read & Research Alzheimer’s More

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Sugar can damage cell proteins via glycation. Now, study finds glycation damage in enzyme for immune function and insulin regulation in early Alzheimer’s. Read & Research Alzheimer’s More

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Positive effects of cognitive training in healthy elderly people have been reported, but data regarding its effects in patients with dementia is unclear. Read & Research Alzheimer’s More

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Newly diagnosed depression in survivors of brain bleeds may signal the onset of dementia. Read & Research Alzheimer’s More

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A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer’s Disease Consortium–Alzheimer’s Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated Read & Research Alzheimer’s More

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We examined mortality, dementia, and progression of hydrocephalic symptoms among untreated individuals with idiopathic normal-pressure hydrocephalus (iNPH) in a population-based sample. Read & Research Alzheimer’s More

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New research finds people who consistently sleep more than 9 hours per night are at a significantly higher risk of developing Alzheimer’s disease. Read & Research Alzheimer’s More

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Smoking, high blood pressure and diabetes were all dementia risks, with diabetes in middle age raising the risk almost as much as a genetic risk factor for Alzheimer’s disease. Read & Research Alzheimer’s More

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A European-wide study published in the journal Neuroepidemiology has found that whilst older people with a higher level of education have better memory function, it does not protect them from… Read & Research Alzheimer’s More

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The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer’s disease (AD). But does it differentiate AD from other neurodegenerative diseases? Read & Research Alzheimer’s More

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There are three common passages found in many presentations, manuscripts, and posters that introduce the burden of Alzheimer’s disease (AD). These include“The socioeconomic costs of Alzheimer’s disease (AD) are enormous and growing at an alarming rate. The total estimated worldwide cost of dementia in 2015 was US$ 818 billion, expected Read & Research Alzheimer’s More

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Findings for genetic correlates of late-onset Alzheimer’s disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. Read & Research Alzheimer’s More

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We aimed to investigate factors defining amyloid-β (1–42) (Aβ1–42) adsorption during preanalytical workup of cerebrospinal fluid (CSF). Read & Research Alzheimer’s More

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Postmenopausal estrogen-based hormone therapy lasting longer than ten years was associated with a decreased risk of Alzheimer’s disease in a large study carried out at the University of Eastern… Read & Research Alzheimer’s More

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Neuroimaging of decreased blood flow in specific regions of the brain can differentiate between depression and cognitive disorders, according to a new report in the Journal of Alzheimer’s Disease. Read & Research Alzheimer’s More

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We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia. Read & Research Alzheimer’s More

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Alzheimer’s disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. Read & Research Alzheimer’s More

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Evidence of chronic traumatic encephalopathy (CTE), a potential cause of dementia caused by repeated blows to the head, has been found in the brains of former association football (soccer) players… Read & Research Alzheimer’s More

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The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Read & Research Alzheimer’s More

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New research examines the metabolism of brain cells and uncovers the calcium exchange mechanism that could lead to Alzheimer’s disease. Read & Research Alzheimer’s More

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New research from Lund University in Sweden has shown that intestinal bacteria can accelerate the development of Alzheimer’s disease. Read & Research Alzheimer’s More

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Rutgers scientists say neurodegenerative diseases like Alzheimer’s and Parkinson’s may be linked to defective brain cells disposing toxic proteins that make neighboring cells sick. Read & Research Alzheimer’s More

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The accuracy of cerebrospinal fluid (CSF) biomarkers for detecting Alzheimer’s disease (AD) pathology has not been fully validated in autopsied nonamnestic dementias. Read & Research Alzheimer’s More

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Preclinical Alzheimer’s disease (AD) is a relatively recent concept describing an entity characterized by the presence of a pathophysiological biomarker signature characteristic for AD in the absence of specific clinical symptoms. There is rising interest in the scientific community to define such an early target population mainly because of failures Read & Research Alzheimer’s More

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