Archive for March, 2017

Misfolded tau and amyloid-β (Aβ) proteins progressively accumulate in the brain, causing decreased and increased neuronal function and neurodegeneration. This study sought to investigate whether the wide spectrum of functional reorganization in aging brains of cognitively normal individuals relates to specific pathological patterns of tau and Aβ deposits. Read & Research Alzheimer’s More

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We compared subject-specific white matter (SSWM) and whole cerebellum (CBL) reference regions for power to detect longitudinal change in amyloid positron emission tomography signal. Read & Research Alzheimer’s More

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Although biomarker studies of late-onset Alzheimer’s disease suggest pathology to be present decades before diagnosis, little is known about cognitive performance at this stage. A sample of 210 adults (aged 40–59) of whom 103 have a parent diagnosed with dementia (family history subgroup) underwent computerized cognitive testing. ApoE status was Read & Research Alzheimer’s More

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Individual Cognitive Stimulation Therapy (iCST), an intervention carried out at home by family caregivers, has little impact on the cognition of patients with dementia, a new study has found, but… Read & Research Alzheimer’s More

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Rehabilitation is important for people with dementia as it is for people with physical disabilities, according to a leading dementia expert. Read & Research Alzheimer’s More

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In experiments with a protein called Ephexin5 that appears to be elevated in the brain cells of Alzheimer’s disease patients and mouse models of the disease, Johns Hopkins researchers say removing… Read & Research Alzheimer’s More

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We discovered a concomitant decline in stroke and dementia incidence rates at a whole population level in Ontario, Canada. This study explores these trends within demographic subgroups. Read & Research Alzheimer’s More

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A new study suggests that regular tea consumption may reduce the risk of cognitive decline, especially for those at genetic risk of Alzheimer’s disease. Read & Research Alzheimer’s More

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A new analysis raises concern over high prescription rates in the USA of a common drug used to treat overactive bladder. Read & Research Alzheimer’s More

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Tau pathology is one of the defining features of Alzheimer disease (AD), which is the most common form of dementia in older age. Read & Research Alzheimer’s More

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We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer’s disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning. Read & Research Alzheimer’s More

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A new Tel Aviv University study published in the Journal of Alzheimer’s Disease finds that insulin resistance, caused in part by obesity and physical inactivity, is also linked to a more rapid… Read & Research Alzheimer’s More

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Researchers from National University Health System (NUHS) have discovered a link between cardiac diseases and brain dysfunction. Read & Research Alzheimer’s More

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The Alzheimer’s Disease Neuroimaging Initiative (ADNI) has continued development and standardization of methodologies for biomarkers and has provided an increased depth and breadth of data available to qualified researchers. This review summarizes the 450+ publications using ADNI data during 2014 and 2015. Read & Research Alzheimer’s More

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New research finds a correlation between the levels of six unsaturated fatty acids and the development of Alzheimer’s disease in older adults. Read & Research Alzheimer’s More

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The clinical meaningfulness of Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS-Cog) subscore change is disputed. We compared 2- to 4-point ADAS-Cog changes with changes in Goal Attainment Scaling (GAS) and everyday function across initial ADAS-Cog scores and treatment responses. Read & Research Alzheimer’s More

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New clinical trial and cohort study investigate the preventive effects of vitamin E and selenium on elderly men with no symptoms of dementia. Read & Research Alzheimer’s More

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The brain-derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer’s disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF’s ability to reduce amyloid β (Aβ) in vitro. We sought to test whether functional BDNF variation interacts with SORL1 genotypes to influence expression and downstream AD-related processes in humans. Read & Research Alzheimer’s More

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Encouraging patients with potential memory deficits to seek early advice from a general practitioner (GP) empowered more of them to consult their GP, but GPs did not change their behavior and refer… Read & Research Alzheimer’s More

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Several nutrients may predict dementia risk. We characterized nutrient biomarker patterns, which integrate the complexity of nutrient exposure and biodisponibility associated with long-term risk of dementia in a large cohort of older persons, the Three-City study. Read & Research Alzheimer’s More

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In the history of medicine, one means to progress is when we make the decision that our assumptions and definitions of disease are no longer consistent with the scientific evidence, and no longer serve our health care needs. The arc of scientific progress is now requiring a change in how Read & Research Alzheimer’s More

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This article describes the public health impact of Alzheimer’s disease (AD), including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. The Special Report examines how the use of biomarkers may influence the AD diagnostic process and estimates of prevalence and incidence of Read & Research Alzheimer’s More

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Variants of the gene TMEM106B may age the brain and raise the risk of neurodegenerative diseases, such as Alzheimer’s, a new study finds. Read & Research Alzheimer’s More

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Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund – the strongest of its kind in the world – to produce images that predate the formation of toxic clumps of… Read & Research Alzheimer’s More

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This perspective binds emerging evidence on the bidirectional relationship between Alzheimer’s disease (AD) and sleep disorders through a model of brain rhythm attractor breakdown. This approach explains behavioral-cognitive changes in AD across the sleep-wake cycle and supports a causal association between early brainstem tau pathology and subsequent cortical amyloid-β accumulation. Read & Research Alzheimer’s More

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A new study finds a link between experiencing rapid drops in blood pressure in middle age and the risk of dementia 20 years later. Read & Research Alzheimer’s More

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Researchers have identified a new mechanism by which inflammation can spread throughout the brain after injury. Read & Research Alzheimer’s More

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In a study of 1566 community-dwelling Japanese elderly who were followed for 5 years, the risk of developing dementia was elevated in individuals with fewer remaining teeth. Read & Research Alzheimer’s More

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Researchers have uncovered a number of compounds – including caffeine – that boost production of the enzyme NMNAT2, which may protect against dementia. Read & Research Alzheimer’s More

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Specialized nerve cells, known as somatostatin-expressing (Sst) interneurons, in the outer part of the mammalian brain (or cerebral cortex) – play a key role in controlling how information flows in… Read & Research Alzheimer’s More

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