Archive for July, 2017

In recent prospective studies, low plasma levels of apolipoprotein E (apoE) are associated with high risk of dementia. Whether this reflects a causal association remains to be established. Read & Research Alzheimer’s More

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New, noninvasive method may help with diagnosis.A new method may help determine whether a person has Alzheimer’s disease or frontotemporal dementia, two different types of dementia that often… Read & Research Alzheimer’s More

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Our previous studies have shown that amyloid β peptide (Aβ) is subject to complement-mediated clearance from the peripheral circulation, and that this mechanism is deficient in Alzheimer’s disease. The mechanism should be enhanced by Aβ antibodies that form immune complexes (ICs) with Aβ, and therefore may be relevant to current Read & Research Alzheimer’s More

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Numerous studies have shown that physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age. Read & Research Alzheimer’s More

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The discovery could ‘spur a new area of Alzheimer’s disease research,’ say the scientists, who found a new pathway of neuronal loss in the condition. Read & Research Alzheimer’s More

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Several studies have reported associations between proton-pump inhibitor (PPI) use and dementia. Read & Research Alzheimer’s More

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This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia for more than 15 years of follow-up. Read & Research Alzheimer’s More

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The old real estate adage about “location, location, location” might also apply to the biochemical genesis of Alzheimer’s disease, according to new research from the University of British Columbia. Read & Research Alzheimer’s More

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The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012. Read & Research Alzheimer’s More

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One in 3 cases of dementia can be prevented by managing key lifestyle factors, such as engaging in more physical exercise and social activities. Read & Research Alzheimer’s More

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The traditional view that protein buildup in the brain causes Alzheimer’s disease is being challenged, and new evidence brings hope of novel drug targets. Read & Research Alzheimer’s More

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New studies reveal links between complex tasks in early life, targeted physical and brain training in later life, and levels of cognition. Read & Research Alzheimer’s More

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Blood screening tests to detect levels of an Alzheimer’s disease marker in the blood may help to predict disease risk and even work to prevent it. Read & Research Alzheimer’s More

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New discovery in motor neurone disease and dementia could pave the way to novel treatments. Read & Research Alzheimer’s More

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Cerebrospinal fluid analysis and other measurements of amyloidosis, such as amyloid-binding positron emission tomography studies, are limited by cost and availability. There is a need for a more practical amyloid β (Aβ) biomarker for central nervous system amyloid deposition. Read & Research Alzheimer’s More

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In a study deemed a ‘massive undertaking’ by the researchers, two new genes have been found that may contribute to the development of Alzheimer’s. Read & Research Alzheimer’s More

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We read with great interest the recent article by Herring et al. [1], who presented a highly detailed explication of potential roles for kallikrein 8 (KLK8) in Alzheimer’s disease (AD); their work highlights how KLK8 inhibition attenuates AD pathology in mice [1]. They illustrated increased KLK8 protein in AD brain, progressing Read & Research Alzheimer’s More

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Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex, formed in the brain at the early stages of Alzheimer’s… Read & Research Alzheimer’s More

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Hyposmia is a term describing partial or complete loss of the sense of smell. Learn about the causes, how it is treated, and related conditions. Read & Research Alzheimer’s More

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A series of studies sheds new light on the racial disparities among Americans living with Alzheimer’s disease. Stress and social adversity play a key role. Read & Research Alzheimer’s More

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It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans. Read & Research Alzheimer’s More

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Research linking traumatic brain injury and dementia later in life is contradictory. Learn about the latest findings and what they mean for TBI patients. Read & Research Alzheimer’s More

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Cinnamon is a widely-used spice in cooking, but Ceylon cinnamon may also help protect against diabetes, Alzheimer’s disease, and other conditions. Read & Research Alzheimer’s More

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The best-established cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease are levels of amyloid-β 42 (Aβ42), total tau (tau), and phosphorylated tau 181 (ptau). We examined whether a widely used commercial immunoassay for CSF Aβ42, tau, and ptau provided stable measurements for more than ∼10 years. Read & Research Alzheimer’s More

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To examine the risk of Alzheimer’s disease (AD) among cancer survivors in a national database. Read & Research Alzheimer’s More

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For nearly 50 years, institutional review boards (IRB) and independent ethics committees have featured local oversight as a core function of research ethics reviews. However growing complexity in Alzheimer’s clinical research suggests current approaches to research volunteer safety is hampering development of new therapeutics. As a partial response to this Read & Research Alzheimer’s More

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New study shows that disruption of slow wave sleep raises amyloid beta, and repeated poor sleep quality raises tau – both hallmarks of Alzheimer’s disease. Read & Research Alzheimer’s More

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Researchers reveal that fisetin, a compound found in strawberries and other fruits and vegetables, reduced cognitive decline in mouse models of aging. Read & Research Alzheimer’s More

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We read with great interest the elegant work by Pascoal et al. [1] describing a synergistic effect between florbetapir uptake values and cerebrospinal fluid (CSF) p-tau levels on the 2-year risk of progression to Alzheimer’s disease (AD) dementia in patients with amnestic mild cognitive impairment (aMCI) from the Alzheimer Disease Neuroimaging Read & Research Alzheimer’s More

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Response letter"> Response letter

Posted July 7, 2017 By

In the letter “A cardinal sin when researching neuropsin: Thou shalt validate antibodies,” Lahiri et al. respond to a study published this December by Herring et al. in Alzheimer’s & Dementia. More specifically, they criticize Herring et al. for an apparent “lack of information on antibody validation”; in particular, they question the antibody Read & Research Alzheimer’s More

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