Two diseases of the modern world—Alzheimer’s and diabetes mellitus—are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading some to speculate that caloric Read & Research Alzheimer’s More
Archive for September, 2017
Alzheimer's disease in humans and other animals—A consequence of postreproductive life span and longevity rather than aging"> Alzheimer's disease in humans and other animals—A consequence of postreproductive life span and longevity rather than aging
Posted September 30, 2017 ByConcomitant vascular and neurodegenerative pathologies double the risk of dementia"> Concomitant vascular and neurodegenerative pathologies double the risk of dementia
Posted September 30, 2017 ByThe relative contributions of vascular and degenerative pathology to dementia are unknown. We aim to quantify the proportion of dementia explained by potentially preventable vascular lesions. Read & Research Alzheimer’s More
Sniffing out dementia with a simple smell test"> Sniffing out dementia with a simple smell test
Posted September 29, 2017 ByA study finds that older adults who could not identify at least 4 out of 5 odors in a smell test were twice as likely to develop dementia 5 years later. Read & Research Alzheimer’s More
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs"> Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
Posted September 22, 2017 ByAlzheimer apolipoprotein E (APOE) ε4,4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to “coordinated lysosomal expression and regulation” (CLEAR) DNA motifs. Read & Research Alzheimer’s More
Alzheimer's disease: When does personality start to change?"> Alzheimer's disease: When does personality start to change?
Posted September 22, 2017 ByA new study examines whether the personality of those affected by dementia or mild cognitive impairment starts to change before the onset of the disease. Read & Research Alzheimer’s More
Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms"> Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms
Posted September 21, 2017 ByTo determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer’s Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). Read & Research Alzheimer’s More
Alzheimer's Association Update"> Alzheimer's Association Update
Posted September 21, 2017 ByThe Alzheimer’s Association International Conference® 2017 (AAIC®) was another record-shattering event in the field of Alzheimer’s and dementia education, research and therapy development. Held in London, United Kingdom, July 15–20, 2017, it brought together nearly 6000 attendees from 70 countries with their unique perspectives—as researchers, clinicians, administrators, and caregivers—to this Read & Research Alzheimer’s More
Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study"> Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study
Posted September 21, 2017 ByWe examined whether obesity at ages 50, 60, and 70 years is associated with subsequent dementia. Changes in body mass index (BMI) for more than 28 years before dementia diagnosis were compared with changes in BMI in those free of dementia. Read & Research Alzheimer’s More
Incidence of dementia in elderly Latin Americans: Results of the Maracaibo Aging Study"> Incidence of dementia in elderly Latin Americans: Results of the Maracaibo Aging Study
Posted September 21, 2017 ByThere are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. Read & Research Alzheimer’s More
Too much or too little magnesium can raise dementia risk"> Too much or too little magnesium can raise dementia risk
Posted September 21, 2017 ByA recently published study investigates the link between both high and low magnesium serum levels and the risk of developing dementia. Read & Research Alzheimer’s More
Alzheimer's: Targeting ApoE gene may 'stop the disease'"> Alzheimer's: Targeting ApoE gene may 'stop the disease'
Posted September 20, 2017 ByThe ApoE gene may have a more influential role than first thought; it may amplify the damage done by the tau protein, causing neurodegeneration. Read & Research Alzheimer’s More
Zeroing out preventable disability: Daring to dream the impossible dream for dementia care"> Zeroing out preventable disability: Daring to dream the impossible dream for dementia care
Posted September 18, 2017 ByAcross the globe, many national public health strategic plans articulate an aspiration to improve the quality of care for individuals with chronic brain disorders that affect memory, movement, and mood. Although few would argue against this intent, the development and delivery of coordinated implementation plans that balances the perspective of Read & Research Alzheimer’s More
Centers for Medicare and Medicaid Services proposes new telehealth services for Medicare beneficiaries"> Centers for Medicare and Medicaid Services proposes new telehealth services for Medicare beneficiaries
Posted September 18, 2017 ByThe Centers for Medicare and Medicaid Services (CMS) has proposed adding new billing codes for telehealth services to benefits in the 2018 Medicare Physician Fee Schedule. Through video conferencing, patient portals, remote vital sign monitoring, and other telecommunications technology, telemedicine allows providers to interact remotely with patients in their home. Read & Research Alzheimer’s More
Alzheimer's disease: New genetic culprit found"> Alzheimer's disease: New genetic culprit found
Posted September 18, 2017 ByA new study challenges the traditional understanding of Alzheimer’s disease, as scientists point to a new gene that may be responsible for the illness. Read & Research Alzheimer’s More
Innovation in care for individuals with cognitive impairment: Can reimbursement policy spread best practices?"> Innovation in care for individuals with cognitive impairment: Can reimbursement policy spread best practices?
Posted September 16, 2017 ByThere is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer’s disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit—long sought Read & Research Alzheimer’s More
A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease"> A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease
Posted September 16, 2017 ByProfiling the spatial-temporal expression pattern and characterizing the regulatory networks of brain tissues are vital for understanding the pathophysiology of Alzheimer’s disease (AD). Read & Research Alzheimer’s More
Knowledge-driven computational modeling in Alzheimer's research: Current state and future trends"> Knowledge-driven computational modeling in Alzheimer's research: Current state and future trends
Posted September 14, 2017 ByNeurodegenerative diseases such as Alzheimer’s disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels Read & Research Alzheimer’s More
Association of midlife lipids with 20-year cognitive change: A cohort study"> Association of midlife lipids with 20-year cognitive change: A cohort study
Posted September 13, 2017 ByExisting studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. Read & Research Alzheimer’s More
How to keep your brain healthy as you age"> How to keep your brain healthy as you age
Posted September 8, 2017 ByA new advisory from the American Heart Association outlines seven steps for preventing age-related cognitive decline and vascular dementia. Read & Research Alzheimer’s More
Hospitalizations for ambulatory care sensitive conditions and unplanned readmissions among Medicare beneficiaries with Alzheimer's disease"> Hospitalizations for ambulatory care sensitive conditions and unplanned readmissions among Medicare beneficiaries with Alzheimer's disease
Posted September 5, 2017 ByMedicare beneficiaries with Alzheimer’s disease and related dementias (ADRDs) may have more potentially avoidable hospitalizations and readmissions than people without dementia. These hospitalizations may be indicative of access barriers, problems in continuity of care, inefficient resource use, and poor patient outcomes. Read & Research Alzheimer’s More
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Posted September 1, 2017 ByEditorial Board"> Editorial Board
Posted September 1, 2017 ByStabilizing TREM2 - a potential strategy to combat Alzheimer's disease"> Stabilizing TREM2 - a potential strategy to combat Alzheimer's disease
Posted September 1, 2017 ByUncovering the molecular mechanism behind a rare genetic risk factor of Alzheimer’s disease points to a new therapeutic target. Read & Research Alzheimer’s More
'Seeing' robot learns tricky technique for studying brain cells in mammals"> 'Seeing' robot learns tricky technique for studying brain cells in mammals
Posted September 1, 2017 ByWhole-cell patch clamp electrophysiology, or whole-cell recording (WCR), is the gold-standard technique for studying the behaviour of brain cells called neurons under different brain states such as… Read & Research Alzheimer’s More