Archive for September, 2017

Two diseases of the modern world—Alzheimer’s and diabetes mellitus—are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading some to speculate that caloric Read & Research Alzheimer’s More

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The relative contributions of vascular and degenerative pathology to dementia are unknown. We aim to quantify the proportion of dementia explained by potentially preventable vascular lesions. Read & Research Alzheimer’s More

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A study finds that older adults who could not identify at least 4 out of 5 odors in a smell test were twice as likely to develop dementia 5 years later. Read & Research Alzheimer’s More

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Alzheimer apolipoprotein E (APOE) ε4,4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to “coordinated lysosomal expression and regulation” (CLEAR) DNA motifs. Read & Research Alzheimer’s More

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A new study examines whether the personality of those affected by dementia or mild cognitive impairment starts to change before the onset of the disease. Read & Research Alzheimer’s More

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To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer’s Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). Read & Research Alzheimer’s More

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The Alzheimer’s Association International Conference® 2017 (AAIC®) was another record-shattering event in the field of Alzheimer’s and dementia education, research and therapy development. Held in London, United Kingdom, July 15–20, 2017, it brought together nearly 6000 attendees from 70 countries with their unique perspectives—as researchers, clinicians, administrators, and caregivers—to this Read & Research Alzheimer’s More

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We examined whether obesity at ages 50, 60, and 70 years is associated with subsequent dementia. Changes in body mass index (BMI) for more than 28 years before dementia diagnosis were compared with changes in BMI in those free of dementia. Read & Research Alzheimer’s More

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There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. Read & Research Alzheimer’s More

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A recently published study investigates the link between both high and low magnesium serum levels and the risk of developing dementia. Read & Research Alzheimer’s More

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The ApoE gene may have a more influential role than first thought; it may amplify the damage done by the tau protein, causing neurodegeneration. Read & Research Alzheimer’s More

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Across the globe, many national public health strategic plans articulate an aspiration to improve the quality of care for individuals with chronic brain disorders that affect memory, movement, and mood. Although few would argue against this intent, the development and delivery of coordinated implementation plans that balances the perspective of Read & Research Alzheimer’s More

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The Centers for Medicare and Medicaid Services (CMS) has proposed adding new billing codes for telehealth services to benefits in the 2018 Medicare Physician Fee Schedule. Through video conferencing, patient portals, remote vital sign monitoring, and other telecommunications technology, telemedicine allows providers to interact remotely with patients in their home. Read & Research Alzheimer’s More

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A new study challenges the traditional understanding of Alzheimer’s disease, as scientists point to a new gene that may be responsible for the illness. Read & Research Alzheimer’s More

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There is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer’s disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit—long sought Read & Research Alzheimer’s More

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Profiling the spatial-temporal expression pattern and characterizing the regulatory networks of brain tissues are vital for understanding the pathophysiology of Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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Neurodegenerative diseases such as Alzheimer’s disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels Read & Research Alzheimer’s More

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Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. Read & Research Alzheimer’s More

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A new advisory from the American Heart Association outlines seven steps for preventing age-related cognitive decline and vascular dementia. Read & Research Alzheimer’s More

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Medicare beneficiaries with Alzheimer’s disease and related dementias (ADRDs) may have more potentially avoidable hospitalizations and readmissions than people without dementia. These hospitalizations may be indicative of access barriers, problems in continuity of care, inefficient resource use, and poor patient outcomes. Read & Research Alzheimer’s More

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Uncovering the molecular mechanism behind a rare genetic risk factor of Alzheimer’s disease points to a new therapeutic target. Read & Research Alzheimer’s More

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Whole-cell patch clamp electrophysiology, or whole-cell recording (WCR), is the gold-standard technique for studying the behaviour of brain cells called neurons under different brain states such as… Read & Research Alzheimer’s More

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