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Revisiting the cholinergic hypothesis in Alzheimer's disease: Emerging evidence from translational and clinical research

Scientific evidence collected over the past four decades suggests that a loss of cholinergic innervation in the cerebral cortex of patients with Alzheimer’s disease (AD) is an early pathogenic event correlated with cognitive impairment. This evidence led to the formulation of the “cholinergic hypothesis of AD” and the development of Read & Research Alzheimer’s More

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