Archive for January, 2018

We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. Read & Research Alzheimer’s More

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Alzheimer’s disease (AD), the most commonly occurring form of dementia worldwide [1], is characterized by two well-defined pathological “hallmarks”, namely extracellular plaque-like deposits of amyloid β (Aβ) peptide and neurofibrillary tangles made up of hyperphosphorylated tau protein, in the brain tissue from diseased human patients [2]. Read & Research Alzheimer’s More

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New research has linked increasing symptoms of anxiety in older adults to higher brain levels of beta-amyloid, a protein linked to Alzheimer’s disease. Read & Research Alzheimer’s More

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With 36 million older adult U.S. drivers, safety is a critical concern, particularly among those with dementia. It is unclear at what stage of Alzheimer’s disease (AD) older adults stop driving and whether preclinical AD affects driving cessation. Read & Research Alzheimer’s More

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The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1–42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer’s disease dementia (ADD; Read & Research Alzheimer’s More

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The stereotypical progression of Alzheimer’s disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non–cell autonomous) Read & Research Alzheimer’s More

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Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. Read & Research Alzheimer’s More

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Mitochondrial genetics are an important but largely neglected area of research in Alzheimer’s disease. A major impediment is the lack of data sets. Read & Research Alzheimer’s More

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Characterizing progression in Alzheimer’s disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free survival in patients with mild cognitive impairment. Read & Research Alzheimer’s More

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Updated American Academy of Neurology guidelines say that regular exercise may improve memory and thinking in people with mild cognitive impairment. Read & Research Alzheimer’s More

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A type 2 diabetes drug that activates three growth factor receptors achieved significant reversal of memory loss in a mouse model of Alzheimer’s disease. Read & Research Alzheimer’s More

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