Archive for February, 2018

Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Read & Research Alzheimer’s More

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We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with PET and predicted clinical progression, even with cutoffs established in an independent cohort. Read & Research Alzheimer’s More

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New research — by scientists in Italy — suggests that a form of age-related hearing loss significantly raises the risk of mild cognitive impairment among seniors. Read & Research Alzheimer’s More

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The synaptic vesicle cycle (SVC) holds center stage in the biology of presynaptic terminals. Through recurrent exocytosis and endocytosis, it facilitates a sequence of events enabling chemical neurotransmission between functionally related neurons. As a fundamental process that links the interior of nerve cells with their environment, the SVC is also Read & Research Alzheimer’s More

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Neuroinflammation is now considered to be of pathophysiologic significance in Alzheimer’s disease and other neurodegenerative conditions. Nonetheless, there is no consensus as to what inflammatory mechanisms need to be combated (or facilitated), how therapies for them should be applied, or when they might be efficacious. Read & Research Alzheimer’s More

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The objective of this study was to evaluate amyloid β (Aβ) deposition patterns in different groups of cerebral β amyloidosis: (1) nondemented with amyloid precursor protein overproduction (Down syndrome); (2) nondemented with abnormal processing of amyloid precursor protein (preclinical autosomal dominant Alzheimer disease); (3) presumed alteration in Aβ clearance with Read & Research Alzheimer’s More

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In a large-scale study, links between alcohol use disorder and dementia are fleshed out. The relationship is stronger than previously thought. Read & Research Alzheimer’s More

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Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer’s disease (AD) process yields conflicting results. Read & Research Alzheimer’s More

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Higher cardiorespiratory fitness is tied to stronger white matter and better cognitive performance in a study of seniors with mild cognitive impairment. Read & Research Alzheimer’s More

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For the first time, scientists achieve a ‘dramatic reversal’ of Alzheimer’s-related brain damage in mice, offering hope for humans. Read & Research Alzheimer’s More

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New research finds that nicotinamide riboside, which is a form of vitamin B-3, has the potential to treat Alzheimer’s. Results in mice are hopeful. Read & Research Alzheimer’s More

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The socioeconomic costs of Alzheimer’s disease (AD) in China and its impact on global economic burden remain uncertain. Read & Research Alzheimer’s More

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A new study examines the effect of positive and negative attitudes toward aging on the risk of developing dementia among at-risk individuals. Read & Research Alzheimer’s More

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A new study examines the brain structure and memory function of monolingual and multilingual people with Alzheimer’s disease and mild cognitive impairment. Read & Research Alzheimer’s More

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Researchers have uncovered a mechanism by which damage to cells that protect blood vessels may lead to Alzheimer’s, and such damage could begin in our 40s. Read & Research Alzheimer’s More

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Researchers suggest that low levels of alcohol can help to improve the function of the glymphatic system, which is the brain’s waste-clearing process. Read & Research Alzheimer’s More

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The National Plan to Address Alzheimer’s Disease stresses the need for public-private partnerships to be coordinated and cooperative to accelerate the state of research and reach the ultimate goal of preventing and effectively treating Alzheimer’s disease by the year 2025. The private-public partnerships in the Alzheimer’s disease community continue to Read & Research Alzheimer’s More

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This study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death. Read & Research Alzheimer’s More

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We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. Read & Research Alzheimer’s More

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Diffusion tensor imaging detects early tissue alterations in Alzheimer’s disease and cerebral small vessel disease (SVD). However, the origin of diffusion alterations in SVD is largely unknown. Read & Research Alzheimer’s More

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Posted February 1, 2018 By

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The National Institute on Aging and the Alzheimer’s Association (NIA-AA) convened a workgroup in 2016 to develop a new Research Framework to promote novel directions for research based on emerging knowledge and new understanding of AD pathophysiology [1]. Read & Research Alzheimer’s More

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Posted February 1, 2018 By

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