Archive for August, 2018

In the largest analysis of its type to date, researchers conclude that stroke significantly increases the risk of developing dementia in older age. Read & Research Alzheimer’s More

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Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. Read & Research Alzheimer’s More

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Using an innovative approach, scientists move one step closer to a treatment for Alzheimer’s. Learning how to tame the brain’s immune system is vital. Read & Research Alzheimer’s More

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A study of blood flow in 128 brain regions in 30,000 people aged 0–105 years has identified behaviors and disorders that speed up brain aging. Read & Research Alzheimer’s More

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A new study links Alzheimer’s toxic waste buildup in the brain to the functioning of the ‘cellular waste removal’ system: the endolysosomal system. Read & Research Alzheimer’s More

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In the largest study of its type, researchers conclude that osteoporosis significantly increases the risk of developing dementia. Read & Research Alzheimer’s More

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A French study of older adults found that having more modifiable cardiovascular health measures at ‘optimal levels’ was tied to lower risk of dementia. Read & Research Alzheimer’s More

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Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here. Read & Research Alzheimer’s More

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Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer’s disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Read & Research Alzheimer’s More

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A minority of patients with sporadic early-onset Alzheimer’s disease (AD) exhibit de novo germ line mutations in the autosomal dominant genes such as APP, PSEN1, or PSEN2. We hypothesized that negatively screened patients may harbor somatic variants in these genes. Read & Research Alzheimer’s More

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The impact of prediabetes and diabetes on cognitive decline and the potential underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes accelerate cognitive decline and brain aging, and the initial pathological changes linked to microvascular processes. Read & Research Alzheimer’s More

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The new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer’s disease conceptual models. However, as a “complex” disease, a model based on systems-level understanding is needed to Read & Research Alzheimer’s More

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By doubling back and re-examining familiar components of the cell, scientists are finding new ways to approach difficult-to-treat diseases. Read & Research Alzheimer’s More

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Identifying ophthalmic diseases associated with increased risk of Alzheimer’s disease (AD) may enable better screening and understanding of those at risk of AD. Read & Research Alzheimer’s More

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In the largest study of its type, researchers conclude that older adults who carry more belly fat are more likely to see a reduction in cognitive ability. Read & Research Alzheimer’s More

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Two common symptoms in people with dementia are agitation and psychosis. Now, a panel of experts explains how best to manage them, and which drugs do work. Read & Research Alzheimer’s More

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Alzheimer’s disease is a progressive neurodegenerative disorder with no known cure. Can an existing drug prevent it from developing in people at high risk? Read & Research Alzheimer’s More

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A large study with a follow-up period of 23 years concludes that both long periods of abstinence and long periods of heavy drinking raise dementia risk. Read & Research Alzheimer’s More

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Vitamin D draws a great deal of scientific attention. In this Spotlight, we delve into recent research and explore the vitamin’s disease-fighting powers. Read & Research Alzheimer’s More

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