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Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease

A minority of patients with sporadic early-onset Alzheimer’s disease (AD) exhibit de novo germ line mutations in the autosomal dominant genes such as APP, PSEN1, or PSEN2. We hypothesized that negatively screened patients may harbor somatic variants in these genes. Read & Research Alzheimer’s More

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