Archive for October, 2018

A 10-year study of 12,000 diverse older adults finds that loneliness, independently of social isolation, is tied to a 40 percent higher risk of dementia. Read & Research Alzheimer’s More

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It may soon be possible to diagnose Alzheimer’s in a matter of seconds using a noninvasive eye scanner that simply examines a person’s retina. Read & Research Alzheimer’s More

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Parkinson’s disease is a neurological condition that affects a person in many different ways. Tremor is a well-known symptom but not the only one. Find out more. Read & Research Alzheimer’s More

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Stress can affect every aspect of our mental and physical health. A new study now shows just how exposure to stress can impact memory and brain volume. Read & Research Alzheimer’s More

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This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance in late middle-aged adults enriched for Alzheimer’s disease (AD) risk. Read & Research Alzheimer’s More

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Research progress on neurocognitive disorders requires donation of both healthy and diseased brains. Here, we describe attitudes toward brain donation among a large community sample in Florida. Read & Research Alzheimer’s More

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The aim was to create readily available algorithms that estimate the individual risk of β-amyloid (Aβ) positivity. Read & Research Alzheimer’s More

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Do you tend to breathe more through your nose or through your mouth? Your answer may affect your ability to consolidate new memories. Read & Research Alzheimer’s More

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We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB–positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. Read & Research Alzheimer’s More

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A large review suggests that the herpes virus may result in a heightened risk of senile dementia, and may account for numerous Alzheimer’s diagnoses. Read & Research Alzheimer’s More

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A postmortem study of brain tissue tests and interviews of those close to the deceased ties some psychiatric symptoms to early Alzheimer’s disease. Read & Research Alzheimer’s More

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We read the recent article by Sommerlad et al. [1] with great interest. This important study showed that, for patients aged >65 years who were known to mental health services with a diagnosis of dementia and who were subsequently admitted to a general medical hospital, only 63.3% received a dementia International Classification Read & Research Alzheimer’s More

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Reimbursement of amyloid-PET is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. The Amyloid Imaging to Prevent Alzheimer’s Disease–Diagnostic and Patient Management Study (AMYPAD-DPMS) is designed to fill this gap. Read & Research Alzheimer’s More

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Our diets can influence the state of our health. Research in mice now suggests that one regimen — the ketogenic diet — may even prevent cognitive decline. Read & Research Alzheimer’s More

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Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbiota influence pathological features of Alzheimer’s disease (AD) including neuroinflammation and amyloid-β deposition. Read & Research Alzheimer’s More

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The findings of a new study suggest that some antidepressants may block the growth of toxic plaques in the brain, thus helping to treat dementia. Read & Research Alzheimer’s More

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The overall goal of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer’s disease (AD) clinical trials. ADNI is a multisite, longitudinal, observational study that has collected many biomarkers since 2004. Recent publications highlight the multifactorial nature of late-onset AD. We discuss selected topics that provide insights Read & Research Alzheimer’s More

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Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria. They have major regulatory and Read & Research Alzheimer’s More

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We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) for a long term are associated with lower cognitive decline and less incident dementia. Read & Research Alzheimer’s More

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Altered cell cycle reentry has been observed in Alzheimer’s disease (AD). DTL was predicted as the top driver of a cell cycle subnetwork associated with AD. Read & Research Alzheimer’s More

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Hearing and sight loss are tied to faster cognitive decline, so does addressing these issues slow down cognitive deterioration? New studies investigate. Read & Research Alzheimer’s More

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People with atrial fibrillation (irregular heartbeat) face an increased risk of dementia, a new study warns; but common drugs may keep that risk in check. Read & Research Alzheimer’s More

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The Alzheimer’s Association convened a multidisciplinary workgroup to develop appropriate use criteria to guide the safe and optimal use of the lumbar puncture procedure and cerebrospinal fluid (CSF) testing for Alzheimer’s disease pathology detection in the diagnostic process. Read & Research Alzheimer’s More

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We explore here a novel model for amyloidogenesis in Alzheimer’s disease (AD). This new perspective on AD amyloidosis seeks to provide a rational framework for incorporating recent and seemingly independent findings on the antimicrobial role of β-amyloid and emerging experimental, genetic, and epidemiological data, suggesting innate immune-mediated inflammation propagates AD Read & Research Alzheimer’s More

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Dementia is an umbrella term that describes symptoms affecting memory and cognitive function. Alzheimer’s disease is a specific, and the most common, type of dementia. The conditions overlap in terms of symptoms, but Alzheimer’s has different and specific treatments as well as unique symptoms. Learn more here. Read & Research Alzheimer’s More

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Predicting who will develop dementia is difficult. Researchers are testing various biomarkers, but a recent study asks whether apathy might provide a clue. Read & Research Alzheimer’s More

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Neurodegenerative diseases encompass a range of diagnoses, such as Alzheimer’s disease and Parkinson’s disease. Despite decades of advancements in understanding the neurobiology of individual diseases, this class has few disease-modifying therapeutics and a paucity of biomarkers for diagnosis or progression. However, tau protein aggregation has emerged as a potential unifying Read & Research Alzheimer’s More

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Little is known about factors affecting motivation and satisfaction of participants in dementia prevention trials. Read & Research Alzheimer’s More

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Posted October 1, 2018 By

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At an estimated $277 billion in 2018 dollars, Alzheimer’s disease (AD) is the most expensive disease in the United States. By 2050, the cost could be as high as $1.1 trillion. AD is the sixth leading cause of death in the United States. AD-related deaths from 2000 to 2015 increased Read & Research Alzheimer’s More

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