Archive for November, 2018

The genetic architecture of Alzheimer’s disease (AD) is only partially understood. Read & Research Alzheimer’s More

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As the older population of the United States grows, the prevalence of dementia also rises. A new paper discusses dementia and gun ownership. Read & Research Alzheimer’s More

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We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer’s disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model mice. Read & Research Alzheimer’s More

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Down syndrome (DS) is associated with an almost universal development of Alzheimer’s disease. Individuals with DS are therefore an important population for randomized controlled trials to prevent or delay cognitive decline, though it is essential to understand the time course of early cognitive changes. Read & Research Alzheimer’s More

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New research uncovers another potential risk factor for dementia and, more generally, for cognitive impairment, namely having a lung disease in midlife. Read & Research Alzheimer’s More

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For the first time, scientists show how the gene that produces brain toxicity in Alzheimer’s is ‘recombined’ using the same enzyme found in HIV. Read & Research Alzheimer’s More

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Thank you for inviting us to respond to the letter from Wilkinson et al. [1] about our recent article on in-hospital diagnosis of dementia. [2] We found that dementia diagnosis was recorded in only 63% of admissions of people with previously diagnosed dementia to a general hospital and that there were Read & Research Alzheimer’s More

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Consumption of orange juice, certain vegetables, leafy greens, and berry fruits is tied to less memory loss in a large group of men followed for 26 years. Read & Research Alzheimer’s More

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The largest genetic study of Alzheimer’s to date finds that this neurological disease shares some genetic risk factors with several cardiovascular conditions. Read & Research Alzheimer’s More

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Building on more than a decade of scientific research, a recent paper brings us one step closer to developing a vaccine for Alzheimer’s disease. Read & Research Alzheimer’s More

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To examine whether an optimized intervention is a more cost-effective option than treatment as usual (TAU) for improving agitation and quality of life in nursing home residents with clinically significant agitation and dementia. Read & Research Alzheimer’s More

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Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer’s disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Read & Research Alzheimer’s More

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Nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer’s disease pathologic changes. We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer’s disease. Read & Research Alzheimer’s More

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Simple mind-body practices altered potential cell aging and Alzheimer’s biomarkers. The changes linked directly to improved cognition and other functions. Read & Research Alzheimer’s More

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In Parkinson’s disease, toxic protein clumps accumulate in the brain’s motor region. A study shows how targeting an enzyme could prevent this. Read & Research Alzheimer’s More

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Like virtually all age-related chronic diseases, late-onset Alzheimer’s disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a Read & Research Alzheimer’s More

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We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Read & Research Alzheimer’s More

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Murine microglia expressing the Alzheimer’s disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microglia. Therefore, we created human pluripotent stem cell (hPSC) monocytes and transdifferentiated microglia-like cells (tMGs) to examine the effect of the Read & Research Alzheimer’s More

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The tau protein plays a central role in Alzheimer’s disease (AD), and there is huge interest in measuring tau in blood and cerebrospinal fluid (CSF). Read & Research Alzheimer’s More

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New research reveals that a protein that helps make connections between neurons in the developing infant brain also strengthens them in the adult brain. Read & Research Alzheimer’s More

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In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer’s disease in veterans. Read & Research Alzheimer’s More

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A deep learning algorithm trained to analyze brain scans accurately predicted who would develop Alzheimer’s more than 6 years before diagnosis. Read & Research Alzheimer’s More

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New research reveals what gives coffee its protective properties for brain health, and why it can help keep Alzheimer’s and Parkinson’s disease at bay. Read & Research Alzheimer’s More

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New research suggests that targeting the brain’s capillary cells with antidiabetes drugs may relieve Alzheimer’s-related brain pathologies. Read & Research Alzheimer’s More

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