The genetic architecture of Alzheimer’s disease (AD) is only partially understood. Read & Research Alzheimer’s More
Archive for November, 2018
A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease"> A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease
Posted November 29, 2018 ByGun ownership and dementia: A growing concern"> Gun ownership and dementia: A growing concern
Posted November 29, 2018 ByAs the older population of the United States grows, the prevalence of dementia also rises. A new paper discusses dementia and gun ownership. Read & Research Alzheimer’s More
Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease"> Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease
Posted November 28, 2018 ByWe investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer’s disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model mice. Read & Research Alzheimer’s More
Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome"> Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome
Posted November 28, 2018 ByDown syndrome (DS) is associated with an almost universal development of Alzheimer’s disease. Individuals with DS are therefore an important population for randomized controlled trials to prevent or delay cognitive decline, though it is essential to understand the time course of early cognitive changes. Read & Research Alzheimer’s More
Lung disease may increase dementia risk"> Lung disease may increase dementia risk
Posted November 27, 2018 ByNew research uncovers another potential risk factor for dementia and, more generally, for cognitive impairment, namely having a lung disease in midlife. Read & Research Alzheimer’s More
Alzheimer's may soon be treated with HIV drugs"> Alzheimer's may soon be treated with HIV drugs
Posted November 26, 2018 ByFor the first time, scientists show how the gene that produces brain toxicity in Alzheimer’s is ‘recombined’ using the same enzyme found in HIV. Read & Research Alzheimer’s More
Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016"> Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016
Posted November 23, 2018 ByThank you for inviting us to respond to the letter from Wilkinson et al. [1] about our recent article on in-hospital diagnosis of dementia. [2] We found that dementia diagnosis was recorded in only 63% of admissions of people with previously diagnosed dementia to a general hospital and that there were Read & Research Alzheimer’s More
Men who eat lots of fruits and vegetables have less memory loss"> Men who eat lots of fruits and vegetables have less memory loss
Posted November 23, 2018 ByConsumption of orange juice, certain vegetables, leafy greens, and berry fruits is tied to less memory loss in a large group of men followed for 26 years. Read & Research Alzheimer’s More
Could managing cholesterol prevent Alzheimer's?"> Could managing cholesterol prevent Alzheimer's?
Posted November 22, 2018 ByThe largest genetic study of Alzheimer’s to date finds that this neurological disease shares some genetic risk factors with several cardiovascular conditions. Read & Research Alzheimer’s More
Alzheimer's vaccine draws closer"> Alzheimer's vaccine draws closer
Posted November 21, 2018 ByBuilding on more than a decade of scientific research, a recent paper brings us one step closer to developing a vaccine for Alzheimer’s disease. Read & Research Alzheimer’s More
Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia"> Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia
Posted November 20, 2018 ByTo examine whether an optimized intervention is a more cost-effective option than treatment as usual (TAU) for improving agitation and quality of life in nursing home residents with clinically significant agitation and dementia. Read & Research Alzheimer’s More
Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease"> Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease
Posted November 19, 2018 ByPrimary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer’s disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Read & Research Alzheimer’s More
A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis"> A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis
Posted November 19, 2018 ByNonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer’s disease pathologic changes. We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer’s disease. Read & Research Alzheimer’s More
A simple type of daily meditation may alter the course of Alzheimer's"> A simple type of daily meditation may alter the course of Alzheimer's
Posted November 16, 2018 BySimple mind-body practices altered potential cell aging and Alzheimer’s biomarkers. The changes linked directly to improved cognition and other functions. Read & Research Alzheimer’s More
Parkinson's disease: Scientists find new target to destroy protein clumps"> Parkinson's disease: Scientists find new target to destroy protein clumps
Posted November 14, 2018 ByIn Parkinson’s disease, toxic protein clumps accumulate in the brain’s motor region. A study shows how targeting an enzyme could prevent this. Read & Research Alzheimer’s More
The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach"> The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach
Posted November 13, 2018 ByLike virtually all age-related chronic diseases, late-onset Alzheimer’s disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a Read & Research Alzheimer’s More
A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium"> A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
Posted November 12, 2018 ByWe explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Read & Research Alzheimer’s More
Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2"> Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
Posted November 12, 2018 ByMurine microglia expressing the Alzheimer’s disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microglia. Therefore, we created human pluripotent stem cell (hPSC) monocytes and transdifferentiated microglia-like cells (tMGs) to examine the effect of the Read & Research Alzheimer’s More
Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease"> Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease
Posted November 9, 2018 ByThe tau protein plays a central role in Alzheimer’s disease (AD), and there is huge interest in measuring tau in blood and cerebrospinal fluid (CSF). Read & Research Alzheimer’s More
How a key protein boosts memory, learning in the adult brain"> How a key protein boosts memory, learning in the adult brain
Posted November 8, 2018 ByNew research reveals that a protein that helps make connections between neurons in the developing infant brain also strengthens them in the adult brain. Read & Research Alzheimer’s More
Military-related risk factors for dementia"> Military-related risk factors for dementia
Posted November 8, 2018 ByIn recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer’s disease in veterans. Read & Research Alzheimer’s More
Alzheimer's: Artificial intelligence predicts onset"> Alzheimer's: Artificial intelligence predicts onset
Posted November 7, 2018 ByA deep learning algorithm trained to analyze brain scans accurately predicted who would develop Alzheimer’s more than 6 years before diagnosis. Read & Research Alzheimer’s More
How coffee protects the brain"> How coffee protects the brain
Posted November 6, 2018 ByNew research reveals what gives coffee its protective properties for brain health, and why it can help keep Alzheimer’s and Parkinson’s disease at bay. Read & Research Alzheimer’s More
Alzheimer's may be treated with diabetes drugs"> Alzheimer's may be treated with diabetes drugs
Posted November 5, 2018 ByNew research suggests that targeting the brain’s capillary cells with antidiabetes drugs may relieve Alzheimer’s-related brain pathologies. Read & Research Alzheimer’s More