Archive for April, 2019

Experts have defined an under-recognized, newly named condition that mimics Alzheimer’s disease and propose guidelines for diagnosing and researching it. Read & Research Alzheimer’s More

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Plasma biomarkers for Alzheimer’s disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there are no well-established plasma markers. Read & Research Alzheimer’s More

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Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Read & Research Alzheimer’s More

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Data from up to 11 years of blood samples confirm neurofilament light protein as a potential noninvasive marker of Alzheimer’s disease progression. Read & Research Alzheimer’s More

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Cerebral small vessel disease (cSVD) comprises pathological processes of the small vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or gait disturbance. It is generally accepted that endothelial dysfunction, including blood-brain barrier (BBB) failure, is pivotal in the pathophysiology. Recent years have seen increasing use Read & Research Alzheimer’s More

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We read with great interest the article by Stites et al. [1] and commend the authors for analyzing stigma of dementia among 317 adults from the US general public. Their study showed that 55% respondents expected a person with dementia to be discriminated by his/her employers, and approximately 46% respondents expected Read & Research Alzheimer’s More

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At blood levels that are typical in humans, an approved high blood pressure drug was able to clear toxic proteins of Parkinson’s disease from mouse brains. Read & Research Alzheimer’s More

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Unlike for glucose, uptake of the brain’s main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Read & Research Alzheimer’s More

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Aaron Klug, who died on November 20, 2018, was a giant of molecular biology [1–3]. He was also a major figure in the study of dementia, especially Alzheimer’s disease. In 1982, Aaron was the sole recipient of the Nobel Prize in Chemistry “for his development of crystallographic electron microscopy and Read & Research Alzheimer’s More

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Scientists have designed a protein that folds into alpha sheets that can block toxic beta-amyloid in brain cells before it forms into large clumps. Read & Research Alzheimer’s More

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In the abstract “Validation of a simple severity scale for assessing ARIA-E,” published in the July 2017 Supplement issue of Alzheimer’s & Dementia, the values in the first column of Table 1 were incorrectly listed as “mm” instead of “cm.” The corrected table is below. Read & Research Alzheimer’s More

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Redressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug “silver bullet”. Read & Research Alzheimer’s More

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Working memory tends to decline with age, and this problem is characterized by poor synchronicity between brain regions. Can researchers ‘fix’ this issue? Read & Research Alzheimer’s More

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Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer’s disease (AD) are not well defined. Read & Research Alzheimer’s More

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Using brain scans that can detect hallmarks of Alzheimer’s could improve diagnosis and clinical care of people with dementia and mild cognitive impairment. Read & Research Alzheimer’s More

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