Archive for April, 2019

At blood levels that are typical in humans, an approved high blood pressure drug was able to clear toxic proteins of Parkinson’s disease from mouse brains. Read & Research Alzheimer’s More

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Unlike for glucose, uptake of the brain’s main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Read & Research Alzheimer’s More

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Aaron Klug, who died on November 20, 2018, was a giant of molecular biology [1–3]. He was also a major figure in the study of dementia, especially Alzheimer’s disease. In 1982, Aaron was the sole recipient of the Nobel Prize in Chemistry “for his development of crystallographic electron microscopy and Read & Research Alzheimer’s More

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Scientists have designed a protein that folds into alpha sheets that can block toxic beta-amyloid in brain cells before it forms into large clumps. Read & Research Alzheimer’s More

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In the abstract “Validation of a simple severity scale for assessing ARIA-E,” published in the July 2017 Supplement issue of Alzheimer’s & Dementia, the values in the first column of Table 1 were incorrectly listed as “mm” instead of “cm.” The corrected table is below. Read & Research Alzheimer’s More

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Redressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug “silver bullet”. Read & Research Alzheimer’s More

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Working memory tends to decline with age, and this problem is characterized by poor synchronicity between brain regions. Can researchers ‘fix’ this issue? Read & Research Alzheimer’s More

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Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer’s disease (AD) are not well defined. Read & Research Alzheimer’s More

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Using brain scans that can detect hallmarks of Alzheimer’s could improve diagnosis and clinical care of people with dementia and mild cognitive impairment. Read & Research Alzheimer’s More

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