Archive for August, 2019

According to a new study, the buildup of toxic tau protein in key areas of the brain leads to major brain cell loss and daytime sleepiness in Alzheimer’s. Read & Research Alzheimer’s More

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Gut microbiota changes before the onset of Alzheimer’s disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. Read & Research Alzheimer’s More

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One of the most reliable studies of its kind has tracked participants over a 28-year period and found that greater social activity can lower dementia risk. Read & Research Alzheimer’s More

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Brain function and memory naturally decline slightly as a person ages, but there are many techniques people can use to improve memory and prevent its loss. Learn about them here. Read & Research Alzheimer’s More

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We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Read & Research Alzheimer’s More

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A new study showcases a blood test that identifies beta-amyloid proteins — a hallmark of Alzheimer’s disease — 20 years before any symptoms of dementia. Read & Research Alzheimer’s More

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There is keen interest in elucidating the biological mechanisms underlying recent failures of β-site amyloid precursor protein–cleaving enzyme-1 (BACE1) inhibitors in Alzheimer’s disease trials. Read & Research Alzheimer’s More

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Sleep-wake disturbances are a common and early feature in Alzheimer’s disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Read & Research Alzheimer’s More

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The purpose of this study was to determine the cost-effectiveness of collaborative dementia care management (DCM). Read & Research Alzheimer’s More

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We sought biological pathways that explained discordance between Alzheimer’s disease (AD) pathology and symptoms. Read & Research Alzheimer’s More

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Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer’s disease (AD). The purpose of this study was to validate the perfusion components of early-phase 18F-florbetapir (eAV45), the 18F-AV45 delivery rate (R1), and 18F-FDG against 15O-H2O PET and assess Read & Research Alzheimer’s More

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New research examines the link between heart health at 50 years of age, and the risk of developing dementia 25 years later, on average. Read & Research Alzheimer’s More

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Traumatic brain injury (TBI) as a risk factor for the development of late-life dementia, including Alzheimer’s disease (AD), is a matter of discussion [1–4], and only a few studies examined the potential relationship between residual TBI lesions and AD neuropathology [5–9]. Examining 4761 deceased participants from the National Alzheimer’s Coordination Read & Research Alzheimer’s More

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We develop a framework to model disease progression across Alzheimer’s disease (AD) and to assess the cost-effectiveness of future disease-modifying therapies (DMTs) for people with mild cognitive impairment (MCI) due to AD. Read & Research Alzheimer’s More

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Researchers have developed a new machine-learning model that they suggest can accurately predict a person’s Alzheimer’s-related cognitive decline. Read & Research Alzheimer’s More

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We aimed to estimate the frequency of each AT(N) (β-amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group. Read & Research Alzheimer’s More

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The corticobasal syndrome (CBS) is associated with several neuropathologic disorders, including corticobasal degeneration and Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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A new study has found a strong association between anemia and dementia. People with either high or low hemoglobin levels had a higher risk. Read & Research Alzheimer’s More

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Specialists call for a more holistic approach to Alzheimer’s research, taking in the brain’s relationship with other organs, including the liver. Read & Research Alzheimer’s More

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Vascular factors increase the risk of Alzheimer’s disease (AD). We investigated the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and cognition. Read & Research Alzheimer’s More

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We previously established that housing loss and residential dislocation in the 2011 Japan earthquake and tsunami was a risk factor for cognitive decline among older survivors. The present study extends the follow-up of survivors out to 6 years. Read & Research Alzheimer’s More

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