A large scale global study from ADI and the London School of Economics and Political Science examines the attitudes of people toward dementia. Read & Research Alzheimer’s More
Archive for September, 2019
95% of people think they could develop dementia with age"> 95% of people think they could develop dementia with age
Posted September 30, 2019 ByAlcohol and dementia risk: A complex relationship"> Alcohol and dementia risk: A complex relationship
Posted September 28, 2019 ByThe relationship between alcohol consumption and dementia risk in older adults is proving difficult to unpick. A recent study takes a fresh look. Read & Research Alzheimer’s More
Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?"> Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?
Posted September 26, 2019 ByThe 2018 National Institute on Aging and the Alzheimer’s Association (NIA-AA) research framework recently redefined Alzheimer’s disease (AD) as a biological construct, based on in vivo biomarkers reflecting key neuropathologic features. Combinations of normal/abnormal levels of three biomarker categories, based on single thresholds, form the AD signature profile that defines the Read & Research Alzheimer’s More
New approach may save brain cells in neurodegenerative diseases"> New approach may save brain cells in neurodegenerative diseases
Posted September 26, 2019 ByNeuron damage and death in Alzheimer’s and other neurodegenerative diseases may be preventable by targeting a shared cause of inflammation. Read & Research Alzheimer’s More
Fluctuating blood pressure may speed up cognitive decline in Alzheimer's"> Fluctuating blood pressure may speed up cognitive decline in Alzheimer's
Posted September 25, 2019 ByNew evidence suggests that managing blood pressure may help slow down the progression of cognitive decline in people with Alzheimer’s disease. Read & Research Alzheimer’s More
Differences in service utilization at an urban tribal health organization before and after Alzheimer's disease or related dementia diagnosis: A cohort study"> Differences in service utilization at an urban tribal health organization before and after Alzheimer's disease or related dementia diagnosis: A cohort study
Posted September 25, 2019 ByThe prevalence, mortality, and healthcare impact of Alaska Native and American Indian (ANAI) people with Alzheimer’s disease and related dementias (ADRD) are unknown. Read & Research Alzheimer’s More
Walking patterns may help differentiate types of dementia"> Walking patterns may help differentiate types of dementia
Posted September 24, 2019 ByA new study suggests that people with Lewy body dementia and Alzheimer’s have distinct walking patterns that may match cognitive and disease changes. Read & Research Alzheimer’s More
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent"> Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent
Posted September 24, 2019 ByQuestions remain about whether apolipoprotein E (APOE)-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains. Read & Research Alzheimer’s More
Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status"> Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status
Posted September 23, 2019 ByThe Multidomain Alzheimer Preventive Trial (MAPT) assessed the efficacy of omega-3 fatty acid supplementation, a multidomain intervention (MI), or a combination of both on cognition. Impact according to cerebral amyloid status was evaluated by PET scan. Read & Research Alzheimer’s More
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Alzheimer's: Head device reduces memory loss in 7 out of 8 people"> Alzheimer's: Head device reduces memory loss in 7 out of 8 people
Posted September 20, 2019 ByA clinical trial has found that an innovative electromagnetic therapy device significantly reduced memory loss in seven out of the eight participants. Read & Research Alzheimer’s More
Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?"> Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?
Posted September 20, 2019 ByWe aimed to refine the hypothesis that dementia has a unique signature of gait impairment reflective of underlying pathology by considering two dementia subtypes, Alzheimer’s disease (AD) and Lewy body disease (LBD), and exploring the role of cognition in disease-specific gait impairments. Read & Research Alzheimer’s More
Can exercise slow down Alzheimer's?"> Can exercise slow down Alzheimer's?
Posted September 19, 2019 ByA new proof-of-concept study finds that people with Alzheimer’s biomarkers in the brain who exercise frequently experience slower deterioration. Read & Research Alzheimer’s More
How to care for someone with Alzheimer's disease"> How to care for someone with Alzheimer's disease
Posted September 18, 2019 ByCaring for someone with Alzheimer’s disease can be both challenging and rewarding. Learn about tips to make it easier, as well as when to seek professional help. Read & Research Alzheimer’s More
Hearing aids lower the chance of dementia, depression, and falling"> Hearing aids lower the chance of dementia, depression, and falling
Posted September 15, 2019 ByA recent study concludes that wearing hearing aids is associated with later onset of dementia and a reduced risk of anxiety, depression, and falls. Read & Research Alzheimer’s More
Migraine may raise dementia, Alzheimer's risk"> Migraine may raise dementia, Alzheimer's risk
Posted September 10, 2019 ByNew research finds a ‘significant’ association between a history of migraine and various forms of dementia, and Alzheimer’s disease in particular. Read & Research Alzheimer’s More
The Alzheimer's Disease Exposome"> The Alzheimer's Disease Exposome
Posted September 10, 2019 ByEnvironmental factors are poorly understood in the etiology of Alzheimer’s disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants. Read & Research Alzheimer’s More
Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study"> Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study
Posted September 9, 2019 ByPoor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. Read & Research Alzheimer’s More
Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review"> Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
Posted September 7, 2019 ByIndividuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late-onset Alzheimer’s disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk. These “resilient” individuals may carry protective genetic factors. Read & Research Alzheimer’s More
A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials"> A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials
Posted September 7, 2019 ByLarge longitudinal biomarkers database focusing on middle age is needed for Alzheimer’s disease (AD) prevention. Read & Research Alzheimer’s More
What to know about raspberry ketones"> What to know about raspberry ketones
Posted September 6, 2019 ByRaspberry ketones are the compounds that give raspberries their smell. Some people believe that they provide health benefits. Learn about the possible uses and side effects of raspberry ketones here. Read & Research Alzheimer’s More
In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals"> In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals
Posted September 6, 2019 ByIt is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β–positive and amyloid-β–negative individuals. Read & Research Alzheimer’s More
MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative"> MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative
Posted September 5, 2019 ByThe low mild cognitive impairment (MCI) to cognitively normal (CN) reversion rate in the Alzheimer’s Disease Neuroimaging Initiative (2-3%) suggests the need to examine reversion by other means. We applied comprehensive neuropsychological criteria (NP criteria) to determine the resulting MCI to CN reversion rate. Read & Research Alzheimer’s More
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay"> Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Posted September 5, 2019 ByPlasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer’s disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. Read & Research Alzheimer’s More
Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries"> Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries
Posted September 4, 2019 ByThere is insufficient understanding of diagnosis of etiologic dementia subtypes and contact with specialized dementia care among older Americans. Read & Research Alzheimer’s More