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Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review

Individuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late-onset Alzheimer’s disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk. These “resilient” individuals may carry protective genetic factors. Read & Research Alzheimer’s More

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