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New research suggests that making healthful lifestyle choices can offset the genetic risk of developing Alzheimer’s and other forms of dementia. Read & Research Alzheimer’s More

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New research suggests that having a relative with Alzheimer’s disease may put people at risk of a premature decline in memory and learning. Read & Research Alzheimer’s More

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Buildup of defective tau protein is a hallmark of Alzheimer’s disease. Now, scientists have identified a molecule that helps clear it from brain cells. Read & Research Alzheimer’s More

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Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Read & Research Alzheimer’s More

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A new blood test for detecting Alzheimer’s disease approaches ‘a level of accuracy that is usable in routine clinical care around the world.’ Read & Research Alzheimer’s More

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Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset. Read & Research Alzheimer’s More

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A number of studies have assessed the relationship between social interaction and dementia; the latest adds to the increasingly complex picture. Read & Research Alzheimer’s More

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Genome-wide association studies (GWAS) discovered multiple late-onset Alzheimer’s disease (LOAD)-associated SNPs and inferred the genes based on proximity; however, the actual causal genes are yet to be identified. Read & Research Alzheimer’s More

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Both high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects. Read & Research Alzheimer’s More

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Drugs that doctors often use in the treatment of overactive bladder, gastrointestinal conditions, and depression may increase dementia risk by almost half. Read & Research Alzheimer’s More

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New research finds that nilvadipine, a drug doctors commonly use to treat high blood pressure, increases the blood flow to the brain’s hippocampus. Read & Research Alzheimer’s More

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Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of Read & Research Alzheimer’s More

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According to the largest research of its kind yet, atrial fibrillation may raise the risk of dementia even in people who did not experience a stroke. Read & Research Alzheimer’s More

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Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that Read & Research Alzheimer’s More

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A study of adults aged 50 and over found that decline in memory and thinking was faster after a heart attack or angina, but not before. Read & Research Alzheimer’s More

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A study of adults aged 50 and over found that decline in memory and thinking was faster after a heart attack or angina, but not before. Read & Research Alzheimer’s More

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Little is known about the longitudinal association between napping and cognitive impairment in older adults. Read & Research Alzheimer’s More

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Scientists find a key difference between Alzheimer’s and frontotemporal dementia: the latter affects a person’s ‘moral emotions’ while the former does not. Read & Research Alzheimer’s More

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New research asks to what extent, if any, a person’s level of education is linked to the presence of Alzheimer’s disease and the rate of cognitive decline. Read & Research Alzheimer’s More

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It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer’s disease (AD) dementia. Read & Research Alzheimer’s More

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Although Alzheimer’s disease (AD) is frequently cited as the most common type of dementia, the relative contributions of vascular and neurodegenerative pathology to clinical dementia have been actually obscure. The systematic review of studies reporting clinicopathologic data of dementia cases sheds important light on this issue [1]. Ten reports were Read & Research Alzheimer’s More

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Mouse study shows that focused ultrasound and injected microbubbles can help curb early Parkinson’s disease by allowing drugs to access the brain. Read & Research Alzheimer’s More

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Researchers from Japan have tested a new gene therapy against Parkinson’s disease using mouse models. Their results suggest that the approach is effective. Read & Research Alzheimer’s More

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Age- and sex-stratified incidence rates of uncommon dementia subtypes are imprecise and scarce. Read & Research Alzheimer’s More

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A large study analyzing the medical data of thousands of people suggests that dementia incidence is lower among those who take blood pressure medication. Read & Research Alzheimer’s More

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A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer’s disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer’s Disease [PREVENT-AD]). Read & Research Alzheimer’s More

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Neuroimaging biomarkers are important for early diagnosis of Alzheimer’s disease, and comparing multimodality neuroimaging to autopsy data is essential. Read & Research Alzheimer’s More

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New research suggests that using a virtual reality simulator could be more effective at detecting Alzheimer’s disease than standard tests. Read & Research Alzheimer’s More

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To report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait. Read & Research Alzheimer’s More

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We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer’s disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Read & Research Alzheimer’s More

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