A new study showcases a blood test that identifies beta-amyloid proteins — a hallmark of Alzheimer’s disease — 20 years before any symptoms of dementia. Read & Research Alzheimer’s More

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There is keen interest in elucidating the biological mechanisms underlying recent failures of β-site amyloid precursor protein–cleaving enzyme-1 (BACE1) inhibitors in Alzheimer’s disease trials. Read & Research Alzheimer’s More

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Sleep-wake disturbances are a common and early feature in Alzheimer’s disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Read & Research Alzheimer’s More

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The purpose of this study was to determine the cost-effectiveness of collaborative dementia care management (DCM). Read & Research Alzheimer’s More

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We sought biological pathways that explained discordance between Alzheimer’s disease (AD) pathology and symptoms. Read & Research Alzheimer’s More

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Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer’s disease (AD). The purpose of this study was to validate the perfusion components of early-phase 18F-florbetapir (eAV45), the 18F-AV45 delivery rate (R1), and 18F-FDG against 15O-H2O PET and assess Read & Research Alzheimer’s More

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New research examines the link between heart health at 50 years of age, and the risk of developing dementia 25 years later, on average. Read & Research Alzheimer’s More

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Traumatic brain injury (TBI) as a risk factor for the development of late-life dementia, including Alzheimer’s disease (AD), is a matter of discussion [1–4], and only a few studies examined the potential relationship between residual TBI lesions and AD neuropathology [5–9]. Examining 4761 deceased participants from the National Alzheimer’s Coordination Read & Research Alzheimer’s More

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We develop a framework to model disease progression across Alzheimer’s disease (AD) and to assess the cost-effectiveness of future disease-modifying therapies (DMTs) for people with mild cognitive impairment (MCI) due to AD. Read & Research Alzheimer’s More

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Researchers have developed a new machine-learning model that they suggest can accurately predict a person’s Alzheimer’s-related cognitive decline. Read & Research Alzheimer’s More

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We aimed to estimate the frequency of each AT(N) (β-amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group. Read & Research Alzheimer’s More

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The corticobasal syndrome (CBS) is associated with several neuropathologic disorders, including corticobasal degeneration and Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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A new study has found a strong association between anemia and dementia. People with either high or low hemoglobin levels had a higher risk. Read & Research Alzheimer’s More

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Specialists call for a more holistic approach to Alzheimer’s research, taking in the brain’s relationship with other organs, including the liver. Read & Research Alzheimer’s More

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Vascular factors increase the risk of Alzheimer’s disease (AD). We investigated the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and cognition. Read & Research Alzheimer’s More

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We previously established that housing loss and residential dislocation in the 2011 Japan earthquake and tsunami was a risk factor for cognitive decline among older survivors. The present study extends the follow-up of survivors out to 6 years. Read & Research Alzheimer’s More

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A new study has found a correlation between having a higher body mass index and waist circumference later in life, and a faster rate of brain aging. Read & Research Alzheimer’s More

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According to a large new longitudinal study, people who eat a lot of hot chili in their daily diet may have a higher risk of cognitive decline. Read & Research Alzheimer’s More

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A new study helps to explain why some Alzheimer’s drugs work in some people but not in others, and why some yet may succeed in animals but not in humans. Read & Research Alzheimer’s More

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New research finds that using a computer and playing games, among other activities, can significantly reduce the risk of mild cognitive impairment. Read & Research Alzheimer’s More

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New research suggests that making healthful lifestyle choices can offset the genetic risk of developing Alzheimer’s and other forms of dementia. Read & Research Alzheimer’s More

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New research suggests that having a relative with Alzheimer’s disease may put people at risk of a premature decline in memory and learning. Read & Research Alzheimer’s More

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Buildup of defective tau protein is a hallmark of Alzheimer’s disease. Now, scientists have identified a molecule that helps clear it from brain cells. Read & Research Alzheimer’s More

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Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Read & Research Alzheimer’s More

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A new blood test for detecting Alzheimer’s disease approaches ‘a level of accuracy that is usable in routine clinical care around the world.’ Read & Research Alzheimer’s More

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Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset. Read & Research Alzheimer’s More

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A number of studies have assessed the relationship between social interaction and dementia; the latest adds to the increasingly complex picture. Read & Research Alzheimer’s More

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Genome-wide association studies (GWAS) discovered multiple late-onset Alzheimer’s disease (LOAD)-associated SNPs and inferred the genes based on proximity; however, the actual causal genes are yet to be identified. Read & Research Alzheimer’s More

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Both high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects. Read & Research Alzheimer’s More

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Drugs that doctors often use in the treatment of overactive bladder, gastrointestinal conditions, and depression may increase dementia risk by almost half. Read & Research Alzheimer’s More

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