Researchers are well aware that significant delays can occur after submitting their protocols to their institutional review boards (IRBs), whether hospital or university based, and whether their project is already funded or not. If the project is multisite and involving multiple IRBs, the delays can be exponential. Read & Research Alzheimer’s More

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Comparative transcriptome analyses in Alzheimer’s disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways. Read & Research Alzheimer’s More

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High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases. Read & Research Alzheimer’s More

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Some people have Alzheimer’s-related brain pathologies but never go on to develop the disease. New research may have found the reason why. Read & Research Alzheimer’s More

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Cortical mean diffusivity (MD) and free water (FW) changes are proposed biomarkers for Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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A new study suggests that anticoagulants – old and new – may have a protective effect against dementia in patients with atrial fibrillation. Read & Research Alzheimer’s More

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Researchers are hopeful that one day, Alzheimer’s disease could be prevented with a vaccine that has recently shown positive results in mice. Read & Research Alzheimer’s More

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Delayed word processing may predict the onset of Alzheimer’s disease, scientists find. The research may lead to new testing practices. Read & Research Alzheimer’s More

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The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Read & Research Alzheimer’s More

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It is unclear whether abnormalities in brain glucose homeostasis are associated with Alzheimer’s disease (AD) pathogenesis. Read & Research Alzheimer’s More

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Researchers reveal how a compound in green tea called EGCG prevents the formation of toxic beta-amyloid plaques, which are a hallmark of Alzheimer’s. Read & Research Alzheimer’s More

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A new study looked at the metabolic changes in the brains of menopausal and perimenopausal women and found potential triggers for Alzheimer’s disease. Read & Research Alzheimer’s More

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A new study looked at the metabolic changes in the brains of menopausal and perimenopausal women and found potential triggers for Alzheimer’s disease. Read & Research Alzheimer’s More

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Scientific evidence collected over the past four decades suggests that a loss of cholinergic innervation in the cerebral cortex of patients with Alzheimer’s disease (AD) is an early pathogenic event correlated with cognitive impairment. This evidence led to the formulation of the “cholinergic hypothesis of AD” and the development of Read & Research Alzheimer’s More

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Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence. Read & Research Alzheimer’s More

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Researchers suggest that the loss of a gene called LSD1 plays a role in the brain cell death that occurs with Alzheimer’s and frontotemporal dementia. Read & Research Alzheimer’s More

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Women who develop high blood pressure in their 40s may be at greater risk of dementia, a new study finds, but this association may not ring true for men. Read & Research Alzheimer’s More

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With the number of bilingual individuals increasing steadily, find out how bilingualism affects the brain and cognitive function. Read & Research Alzheimer’s More

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Two diseases of the modern world—Alzheimer’s and diabetes mellitus—are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading some to speculate that caloric Read & Research Alzheimer’s More

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The relative contributions of vascular and degenerative pathology to dementia are unknown. We aim to quantify the proportion of dementia explained by potentially preventable vascular lesions. Read & Research Alzheimer’s More

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A study finds that older adults who could not identify at least 4 out of 5 odors in a smell test were twice as likely to develop dementia 5 years later. Read & Research Alzheimer’s More

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Alzheimer apolipoprotein E (APOE) ε4,4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to “coordinated lysosomal expression and regulation” (CLEAR) DNA motifs. Read & Research Alzheimer’s More

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A new study examines whether the personality of those affected by dementia or mild cognitive impairment starts to change before the onset of the disease. Read & Research Alzheimer’s More

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To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer’s Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). Read & Research Alzheimer’s More

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The Alzheimer’s Association International Conference® 2017 (AAIC®) was another record-shattering event in the field of Alzheimer’s and dementia education, research and therapy development. Held in London, United Kingdom, July 15–20, 2017, it brought together nearly 6000 attendees from 70 countries with their unique perspectives—as researchers, clinicians, administrators, and caregivers—to this Read & Research Alzheimer’s More

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We examined whether obesity at ages 50, 60, and 70 years is associated with subsequent dementia. Changes in body mass index (BMI) for more than 28 years before dementia diagnosis were compared with changes in BMI in those free of dementia. Read & Research Alzheimer’s More

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There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. Read & Research Alzheimer’s More

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A recently published study investigates the link between both high and low magnesium serum levels and the risk of developing dementia. Read & Research Alzheimer’s More

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The ApoE gene may have a more influential role than first thought; it may amplify the damage done by the tau protein, causing neurodegeneration. Read & Research Alzheimer’s More

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Across the globe, many national public health strategic plans articulate an aspiration to improve the quality of care for individuals with chronic brain disorders that affect memory, movement, and mood. Although few would argue against this intent, the development and delivery of coordinated implementation plans that balances the perspective of Read & Research Alzheimer’s More

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