Vitamin D draws a great deal of scientific attention. In this Spotlight, we delve into recent research and explore the vitamin’s disease-fighting powers. Read & Research Alzheimer’s More

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Researchers identify better techniques for the development of more effective Alzheimer’s therapy. This may allow them to tackle the disease in the brain. Read & Research Alzheimer’s More

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Contact sports can lead to brain injury, which is why they are associated with dementia. New research explains why they may also increase Parkinson’s risk. Read & Research Alzheimer’s More

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New drugs for diverse inflammatory diseases — from Alzheimer’s and Parkinson’s to cancer and osteoarthritis — may come from the discovery of a new target. Read & Research Alzheimer’s More

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New studies conclude that individuals with Alzheimer’s are more sensitive to opioids. Researchers call for a review of how pain medication is given. Read & Research Alzheimer’s More

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Feeling dizzy when you stand up — or orthostatic hypotension — might predict the development of dementia in later life, according to a new study. Read & Research Alzheimer’s More

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New research shows how the brain integrates smells with spatiotemporal information to create memories. The findings also shed new light on Alzheimer’s. Read & Research Alzheimer’s More

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A new factor that may influence the risk of Alzheimer’s has emerged: the liver’s ability to produce enough phospholipids that help protect brain health. Read & Research Alzheimer’s More

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Several neurodegenerative brain proteinopathies, including Alzheimer’s disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. Read & Research Alzheimer’s More

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Glaucoma can lead to vision loss, but a turmeric derivative can improve current treatments. New research devises a viable method of adding it to eye drops. Read & Research Alzheimer’s More

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Cerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy. We examined CSF concentrations of total tau (t-tau), phosphorylated tau, and amyloid β1-42 and their association with RHI in former National Football League (NFL) players. The Read & Research Alzheimer’s More

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Erratum"> Erratum

Posted July 21, 2018 By

In the article “Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years,” published in the January 2018 issue of Alzheimer’s & Dementia, several corrections to the article were inadvertently omitted. A revised version of the manuscript is available online at https://doi.org/10.1016/j.jalz.2017.06.2264. Read & Research Alzheimer’s More

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Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer’s disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suitable for drug screening. To create a new in vitro tauopathy model, we generated a footprint-free triple Read & Research Alzheimer’s More

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Molecular imaging techniques using 18F-fluorodeoxyglucose, amyloid tracers, and, more recently, tau ligands have taken dementia research by storm and undoubtedly improved our understanding of neurodegenerative diseases. The ability to image in vivo the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better Read & Research Alzheimer’s More

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Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Read & Research Alzheimer’s More

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New research offers ‘the first population evidence for a causal link’ between herpes infection and the development of Alzheimer’s disease. Read & Research Alzheimer’s More

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Systematic review of clinical studies finds no robust evidence that vitamin D protects the brain against diseases such as Alzheimer’s, MS, and Parkinson’s. Read & Research Alzheimer’s More

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A new study looking at links between hypertension in later life and brain health finds an increased risk of Alzheimer’s hallmarks and brain lesions. Read & Research Alzheimer’s More

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Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Read & Research Alzheimer’s More

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A study saw that drugs that stabilize the cells lining small blood vessels in the brain reversed symptoms of a common cause of stroke and dementia in rats. Read & Research Alzheimer’s More

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Observational multimodal neuroimaging studies indicate sex differences in Alzheimer’s disease pathophysiological markers. Read & Research Alzheimer’s More

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Obesity and loss of muscle mass, independently, increase the risk of cognitive decline in older adults. Put them together, and the risk is exacerbated. Read & Research Alzheimer’s More

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A new study finds that obstructive sleep apnea is tied to brain structure alterations found in early dementia and that low blood oxygen might be a factor. Read & Research Alzheimer’s More

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Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men. Read & Research Alzheimer’s More

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Alzheimer’s disease (AD) symptoms reflect synaptic dysfunction and neuron death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl-D-aspartate receptors (NMDARs), contributing to synaptic dysfunction. The study described here tested the hypothesis that AβO-stimulated calcium entry also drives neuronal cell cycle reentry (CCR), a prelude to neuron death Read & Research Alzheimer’s More

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People with long-lasting heightened inflammation from middle age onwards also have more white matter damage. This may foreshadow dementia, researchers say. Read & Research Alzheimer’s More

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A new study suggests that taking aspirin in low, regular doses may reduce the buildup of Alzheimer’s-specific amyloid plaque in the brain. Read & Research Alzheimer’s More

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This study examined a longitudinal trajectory of β-amyloid (Aβ) accumulation at the predementia stage of Alzheimer’s disease in the context of clinical trials. Read & Research Alzheimer’s More

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Consent is generally required for research and sharing rich individual-level data but presents additional ethical and legal challenges where participants have diminished decision-making capacity. We formed a multi-disciplinary team to develop best practices for consent in data-intensive dementia research. We recommend that consent processes for research and data sharing support Read & Research Alzheimer’s More

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A recent study shows how an obesity-inducing diet — high in sugar and fats — boosts the detrimental effect of natural aging, increasing Alzheimer’s risk. Read & Research Alzheimer’s More

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