At an estimated $277 billion in 2018 dollars, Alzheimer’s disease (AD) is the most expensive disease in the United States. By 2050, the cost could be as high as $1.1 trillion. AD is the sixth leading cause of death in the United States. AD-related deaths from 2000 to 2015 increased Read & Research Alzheimer’s More

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New research supports the idea that physical activity delays cognitive decline and other changes in the rare early-onset form of Alzheimer’s disease. Read & Research Alzheimer’s More

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Now that scientists agree that oligomer protein deposits cause Alzheimer’s, an international team has detailed a plan for developing drugs to target them. Read & Research Alzheimer’s More

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Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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The first study to ever predict Alzheimer’s prevalence by race and ethnicity estimates that the United States burden of the disease will double by 2060. Read & Research Alzheimer’s More

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A number of risk factors are known for dementia; these include hypertension, a sedentary lifestyle, obesity, and smoking. A new study may add another. Read & Research Alzheimer’s More

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We tested the hypothesis that low plasma complement C3 is observationally and genetically associated with high risk of Alzheimer’s disease. Read & Research Alzheimer’s More

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In 2016, the UC Davis Latino Aging Research Resource Center and UC Davis Alzheimer’s Disease Center brought together experts from across the country to consolidate current knowledge and identify future directions in aging and diversity research. This report disseminates the research priorities that emerged from this conference, building on an Read & Research Alzheimer’s More

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We sought to examine the genetic overlap between vascular pathologies and Alzheimer’s disease (AD) dementia, and the potential mediating role of vascular pathologies between AD-related genetic variants and late-life cognition. Read & Research Alzheimer’s More

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Several concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been Read & Research Alzheimer’s More

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The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). Read & Research Alzheimer’s More

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According to a new study, there may be a link between daytime sleepiness and an increased risk of developing Alzheimer’s later in life. Read & Research Alzheimer’s More

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A new study investigating seasonal variation in cognitive ability concludes that more people reach the threshold for a dementia diagnosis in winter. Read & Research Alzheimer’s More

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The trends in prevalence and incidence of Alzheimer’s disease (AD) dementia remain uncertain. Read & Research Alzheimer’s More

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Tangles of tau protein are a hallmark of Alzheimer’s disease. Now, scientists have uncovered a new mechanism through which tau disrupts brain cells. Read & Research Alzheimer’s More

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A new study provides 10-year estimates for dementia risk, focusing on age, sex, and genetic predisposition. This may lead to early preventive initiatives. Read & Research Alzheimer’s More

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An existing drug used to treat liver disease could also be effective in Alzheimer’s disease, researchers find. Better Alzheimer’s therapy is much needed. Read & Research Alzheimer’s More

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In the largest analysis of its type to date, researchers conclude that stroke significantly increases the risk of developing dementia in older age. Read & Research Alzheimer’s More

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Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. Read & Research Alzheimer’s More

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Using an innovative approach, scientists move one step closer to a treatment for Alzheimer’s. Learning how to tame the brain’s immune system is vital. Read & Research Alzheimer’s More

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A study of blood flow in 128 brain regions in 30,000 people aged 0–105 years has identified behaviors and disorders that speed up brain aging. Read & Research Alzheimer’s More

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A new study links Alzheimer’s toxic waste buildup in the brain to the functioning of the ‘cellular waste removal’ system: the endolysosomal system. Read & Research Alzheimer’s More

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In the largest study of its type, researchers conclude that osteoporosis significantly increases the risk of developing dementia. Read & Research Alzheimer’s More

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A French study of older adults found that having more modifiable cardiovascular health measures at ‘optimal levels’ was tied to lower risk of dementia. Read & Research Alzheimer’s More

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Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here. Read & Research Alzheimer’s More

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Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer’s disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Read & Research Alzheimer’s More

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A minority of patients with sporadic early-onset Alzheimer’s disease (AD) exhibit de novo germ line mutations in the autosomal dominant genes such as APP, PSEN1, or PSEN2. We hypothesized that negatively screened patients may harbor somatic variants in these genes. Read & Research Alzheimer’s More

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The impact of prediabetes and diabetes on cognitive decline and the potential underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes accelerate cognitive decline and brain aging, and the initial pathological changes linked to microvascular processes. Read & Research Alzheimer’s More

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The new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer’s disease conceptual models. However, as a “complex” disease, a model based on systems-level understanding is needed to Read & Research Alzheimer’s More

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By doubling back and re-examining familiar components of the cell, scientists are finding new ways to approach difficult-to-treat diseases. Read & Research Alzheimer’s More

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