Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer’s disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains unclear. Read & Research Alzheimer’s More

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Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer’s disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Read & Research Alzheimer’s More

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Individuals in early stages of Alzheimer’s disease are a targeted population for secondary prevention trials aimed at preserving normal cognition. Understanding within-person biomarker(s) change over time is critical for trial enrollment and design. Read & Research Alzheimer’s More

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Harmful formations in the brains of people with Alzheimer’s might be responsible for much of the neural damage. Can a beet-derived pigment prevent the harm? Read & Research Alzheimer’s More

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Agitation and aggression are among the most challenging symptoms of dementia. Agitated persons with dementia can harm themselves, their caregivers, or other patients in a care facility. Automatic detection of agitation would be useful to alert caregivers so that appropriate interventions can be performed. The building blocks in the automatic Read & Research Alzheimer’s More

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Biomedical data sets are becoming increasingly larger and a plethora of high-dimensionality data sets (“Big Data”) are now freely accessible for neurodegenerative diseases, such as Alzheimer’s disease. It is thus important that new informatic analysis platforms are developed that allow the organization and interrogation of Big Data resources into a Read & Research Alzheimer’s More

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A new study from Sweden asks whether the level of physical fitness at middle age could influence women’s risk of developing dementia later in life. Read & Research Alzheimer’s More

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Alzheimer’s disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain. Read & Research Alzheimer’s More

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Neuropsychiatric symptoms are common in Alzheimer’s disease. Previous research has attempted to identify subsyndromes—sets of symptoms related to one another—to clarify underlying mechanisms and treatment targets. We examined the stability of these subsyndromes over time. Read & Research Alzheimer’s More

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The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer’s disease (AD), but its implication in other dementias is less well studied. Read & Research Alzheimer’s More

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Inheritance of the ε4 allele of apolipoprotein E (APOE) increases a person’s risk of developing both Alzheimer’s disease (AD) and Lewy body dementia (LBD), yet the underlying mechanisms behind this risk are incompletely understood. The recent identification of reduced APOE DNA methylation in AD postmortem brains prompted this study to Read & Research Alzheimer’s More

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Excessive daytime sleepiness may be an early warning sign of Alzheimer’s, but what is the possible mechanism underlying this association? Read & Research Alzheimer’s More

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A new study has proposed that blood levels of branched-chain amino acids and other metabolites may reveal risk of future dementia and Alzheimer’s disease. Read & Research Alzheimer’s More

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The TOMM40 poly-T is a polymorphism in intron 6 of the TOMM40 gene, which is adjacent to and in linkage disequilibrium with APOE. Roses et al identified the association between the length of TOMM40 poly-T with the risk and age of onset of late-onset Alzheimer’s disease (LOAD). Following the original discovery, Read & Research Alzheimer’s More

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Two new studies show how a receptor activates immune cells in the brain to ‘eat up’ amyloid beta, thereby slowing down the progression of Alzheimer’s. Read & Research Alzheimer’s More

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Among adults in their 50s, researchers identified those with mild cognitive impairment — a precursor of Alzheimer’s — from their polygenic risk scores. Read & Research Alzheimer’s More

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Amid rising worries that sports-related head injuries may damage health long-term, a new study suggests that they may be tied to the onset of dementia. Read & Research Alzheimer’s More

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Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into mechanisms underlying incident dementia and Alzheimer’s disease. Read & Research Alzheimer’s More

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Having cholesterol higher than it was in midlife was linked to lower risk of marked cognitive decline in those aged 85–94, compared with those aged 75–84. Read & Research Alzheimer’s More

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Some associations of high total cholesterol with dementia risk diminish as the outcome age—age at cognitive assessment—increases. Read & Research Alzheimer’s More

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Levels of amyloid β peptide 42 (Aβ42), total tau, and phosphorylated tau-181 are well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease, but variability in manual plate-based assays has limited their use. We examined the relationship between CSF biomarkers, as measured by a novel automated immunoassay platform, and amyloid positron emission Read & Research Alzheimer’s More

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Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Read & Research Alzheimer’s More

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We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with PET and predicted clinical progression, even with cutoffs established in an independent cohort. Read & Research Alzheimer’s More

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New research — by scientists in Italy — suggests that a form of age-related hearing loss significantly raises the risk of mild cognitive impairment among seniors. Read & Research Alzheimer’s More

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The synaptic vesicle cycle (SVC) holds center stage in the biology of presynaptic terminals. Through recurrent exocytosis and endocytosis, it facilitates a sequence of events enabling chemical neurotransmission between functionally related neurons. As a fundamental process that links the interior of nerve cells with their environment, the SVC is also Read & Research Alzheimer’s More

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Neuroinflammation is now considered to be of pathophysiologic significance in Alzheimer’s disease and other neurodegenerative conditions. Nonetheless, there is no consensus as to what inflammatory mechanisms need to be combated (or facilitated), how therapies for them should be applied, or when they might be efficacious. Read & Research Alzheimer’s More

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The objective of this study was to evaluate amyloid β (Aβ) deposition patterns in different groups of cerebral β amyloidosis: (1) nondemented with amyloid precursor protein overproduction (Down syndrome); (2) nondemented with abnormal processing of amyloid precursor protein (preclinical autosomal dominant Alzheimer disease); (3) presumed alteration in Aβ clearance with Read & Research Alzheimer’s More

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In a large-scale study, links between alcohol use disorder and dementia are fleshed out. The relationship is stronger than previously thought. Read & Research Alzheimer’s More

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Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer’s disease (AD) process yields conflicting results. Read & Research Alzheimer’s More

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Higher cardiorespiratory fitness is tied to stronger white matter and better cognitive performance in a study of seniors with mild cognitive impairment. Read & Research Alzheimer’s More

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