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Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration">Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration

Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer’s disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suitable for drug screening. To create a new in vitro tauopathy model, we generated a footprint-free triple Read & Research Alzheimer’s More

Molecular imaging in dementia: Past, present, and future">Molecular imaging in dementia: Past, present, and future

Molecular imaging techniques using 18F-fluorodeoxyglucose, amyloid tracers, and, more recently, tau ligands have taken dementia research by storm and undoubtedly improved our understanding of neurodegenerative diseases. The ability to image in vivo the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better Read & Research Alzheimer’s More

Sleep disturbances and dementia risk: A multicenter study">Sleep disturbances and dementia risk: A multicenter study

Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Read & Research Alzheimer’s More

Alzheimer's risk 10 times lower with herpes medication">Alzheimer's risk 10 times lower with herpes medication

New research offers ‘the first population evidence for a causal link’ between herpes infection and the development of Alzheimer’s disease. Read & Research Alzheimer’s More

Vitamin D offers no protection against Alzheimer's">Vitamin D offers no protection against Alzheimer's

Systematic review of clinical studies finds no robust evidence that vitamin D protects the brain against diseases such as Alzheimer’s, MS, and Parkinson’s. Read & Research Alzheimer’s More

High blood pressure may increase dementia risk">High blood pressure may increase dementia risk

A new study looking at links between hypertension in later life and brain health finds an increased risk of Alzheimer’s hallmarks and brain lesions. Read & Research Alzheimer’s More

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale">Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Read & Research Alzheimer’s More

Common cause of dementia may be treatable">Common cause of dementia may be treatable

A study saw that drugs that stabilize the cells lining small blood vessels in the brain reversed symptoms of a common cause of stroke and dementia in rats. Read & Research Alzheimer’s More

'Skinny fat' linked to cognitive decline, study warns">'Skinny fat' linked to cognitive decline, study warns

Obesity and loss of muscle mass, independently, increase the risk of cognitive decline in older adults. Put them together, and the risk is exacerbated. Read & Research Alzheimer’s More

Why might sleep apnea raise dementia risk?">Why might sleep apnea raise dementia risk?

A new study finds that obstructive sleep apnea is tied to brain structure alterations found in early dementia and that low blood oxygen might be a factor. Read & Research Alzheimer’s More

N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease">N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

Alzheimer’s disease (AD) symptoms reflect synaptic dysfunction and neuron death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl-D-aspartate receptors (NMDARs), contributing to synaptic dysfunction. The study described here tested the hypothesis that AβO-stimulated calcium entry also drives neuronal cell cycle reentry (CCR), a prelude to neuron death Read & Research Alzheimer’s More

Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes">Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes

Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men. Read & Research Alzheimer’s More

Dementia linked to 'chronic, rather than temporary' inflammation">Dementia linked to 'chronic, rather than temporary' inflammation

People with long-lasting heightened inflammation from middle age onwards also have more white matter damage. This may foreshadow dementia, researchers say. Read & Research Alzheimer’s More

Alzheimer's: Aspirin may reduce toxic plaque">Alzheimer's: Aspirin may reduce toxic plaque

A new study suggests that taking aspirin in low, regular doses may reduce the buildup of Alzheimer’s-specific amyloid plaque in the brain. Read & Research Alzheimer’s More

Consent recommendations for research and international data sharing involving persons with dementia">Consent recommendations for research and international data sharing involving persons with dementia

Consent is generally required for research and sharing rich individual-level data but presents additional ethical and legal challenges where participants have diminished decision-making capacity. We formed a multi-disciplinary team to develop best practices for consent in data-intensive dementia research. We recommend that consent processes for research and data sharing support Read & Research Alzheimer’s More

Aging, obesity may prime the brain for Alzheimer's">Aging, obesity may prime the brain for Alzheimer's

A recent study shows how an obesity-inducing diet — high in sugar and fats — boosts the detrimental effect of natural aging, increasing Alzheimer’s risk. Read & Research Alzheimer’s More

Reduce the burden of dementia now">Reduce the burden of dementia now

Although Congress has allocated substantial funding to accelerate dementia research, nearly all attempts to find effective preventions and treatments for dementia have failed. Current dementia therapies offer little hope. They provide only modest clinical benefits and have limited impact on the unrelenting progression of disease. With few means to slow Read & Research Alzheimer’s More

What is the purpose of a vitamin B-12 level test?">What is the purpose of a vitamin B-12 level test?

The body needs vitamin B-12 for many processes. People with a deficiency may have neurological symptoms and fatigue, while an excess may indicate liver disease or diabetes. Doctors can use a vitamin B-12 level test to determine how much B-12 is in the body. Find out more about the test Read & Research Alzheimer’s More

What are the signs of early-onset Alzheimer's?">What are the signs of early-onset Alzheimer's?

Early-onset Alzheimer’s disease is a form of dementia that begins before the age of 65. Recognizing the initial symptoms can help a person seek treatment earlier and slow the progression of the disease. In this article, learn about ten signs of early-onset Alzheimer’s. We also cover how to help a Read & Research Alzheimer’s More

Biomarkers of agitation and aggression in Alzheimer's disease: A systematic review">Biomarkers of agitation and aggression in Alzheimer's disease: A systematic review

Agitation is one of the most challenging neuropsychiatric symptoms to treat in Alzheimer’s disease and has significant implications for patient and caregiver. A major source of difficulty in identifying safe and effective treatments for agitation is the lack of validated biomarkers. As such, patients may not be appropriately targeted, and Read & Research Alzheimer’s More

The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review">The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review

Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer’s disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Read & Research Alzheimer’s More

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia">Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome Read & Research Alzheimer’s More

Alzheimer's: 'Strong evidence' of virus involvement">Alzheimer's: 'Strong evidence' of virus involvement

A study of large sets of postmortem data provides new evidence that viruses — herpes HHV-6 and HHV-7 in particular — may be involved in Alzheimer’s. Read & Research Alzheimer’s More

Ethical adoption: A new imperative in the development of technology for dementia">Ethical adoption: A new imperative in the development of technology for dementia

Technology interventions are showing promise to assist persons with dementia and their carers. However, low adoption rates for these technologies and ethical considerations have impeded the realization of their full potential. Read & Research Alzheimer’s More

Helicobacter pylori and the risk of dementia: A population-based study">Helicobacter pylori and the risk of dementia: A population-based study

Helicobacter pylori infection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population-based cohort. Read & Research Alzheimer’s More

Smoking and diabetes 'risk factors' for calcium buildup in brain">Smoking and diabetes 'risk factors' for calcium buildup in brain

A study of brain CT scans of patients with memory problems found that diabetes and smoking were linked to hippocampal calcifications. Read & Research Alzheimer’s More