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CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease">CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease

Because currently known Alzheimer’s disease (AD) single-nucleotide polymorphisms only account for a small fraction of the genetic variance in this disease, there is a need to identify new variants associated with AD. Read & Research Alzheimer’s More

Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting">Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting

We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. Read & Research Alzheimer’s More

Alzheimer's disease, cellular prion protein, and dolphins">Alzheimer's disease, cellular prion protein, and dolphins

Alzheimer’s disease (AD), the most commonly occurring form of dementia worldwide [1], is characterized by two well-defined pathological “hallmarks”, namely extracellular plaque-like deposits of amyloid β (Aβ) peptide and neurofibrillary tangles made up of hyperphosphorylated tau protein, in the brain tissue from diseased human patients [2]. Read & Research Alzheimer’s More

Anxiety may be an early sign of Alzheimer's">Anxiety may be an early sign of Alzheimer's

New research has linked increasing symptoms of anxiety in older adults to higher brain levels of beta-amyloid, a protein linked to Alzheimer’s disease. Read & Research Alzheimer’s More

Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1–42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40">Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1–42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40

The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1–42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer’s disease dementia (ADD; Read & Research Alzheimer’s More

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers">Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers

With 36 million older adult U.S. drivers, safety is a critical concern, particularly among those with dementia. It is unclear at what stage of Alzheimer’s disease (AD) older adults stop driving and whether preclinical AD affects driving cessation. Read & Research Alzheimer’s More

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies">Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. Read & Research Alzheimer’s More

Regional vulnerability in Alzheimer's: The role of cell-autonomous and transneuronal processes">Regional vulnerability in Alzheimer's: The role of cell-autonomous and transneuronal processes

The stereotypical progression of Alzheimer’s disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non–cell autonomous) Read & Research Alzheimer’s More

Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping">Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping

Mitochondrial genetics are an important but largely neglected area of research in Alzheimer’s disease. A major impediment is the lack of data sets. Read & Research Alzheimer’s More

A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data">A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data

Characterizing progression in Alzheimer’s disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free survival in patients with mild cognitive impairment. Read & Research Alzheimer’s More

Mild cognitive impairment 'treatable' with regular exercise, say experts">Mild cognitive impairment 'treatable' with regular exercise, say experts

Updated American Academy of Neurology guidelines say that regular exercise may improve memory and thinking in people with mild cognitive impairment. Read & Research Alzheimer’s More

Alzheimer's: 'Triple-action' diabetes drug shows promise as treatment">Alzheimer's: 'Triple-action' diabetes drug shows promise as treatment

A type 2 diabetes drug that activates three growth factor receptors achieved significant reversal of memory loss in a mouse model of Alzheimer’s disease. Read & Research Alzheimer’s More

Alzheimer's Association Update">Alzheimer's Association Update

Investigators from 26 countries met in Varna, Bulgaria, October 19–20, 2017, at the second in a series of Alzheimer’s Association International Conference® satellite symposia. Researchers discussed new pathways in Alzheimer’s disease (AD) and dementia research, with a particular focus on new therapeutic opportunities. The goals of the meeting were three-fold: Read & Research Alzheimer’s More

AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease">AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease

AF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. Read & Research Alzheimer’s More

Walk 4,000 steps every day to boost brain function">Walk 4,000 steps every day to boost brain function

Cognitive decline is a distressing experience, but there may be an easy way of keeping your brain healthy. Just take a moderately long walk every day. Read & Research Alzheimer’s More

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages">Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

Genetic associations for endophenotypes of Alzheimer’s disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated. Read & Research Alzheimer’s More

Could blueberry vinegar tackle memory loss?">Could blueberry vinegar tackle memory loss?

Blueberry vinegar could benefit people with dementia, say researchers, after finding that the fermented product improved memory in mice with amnesia. Read & Research Alzheimer’s More

Why do older people forget overnight? Study investigates">Why do older people forget overnight? Study investigates

A new study has suggested that uncoupling between slow waves and spindles in non-REM sleep may be the cause of overnight forgetting in older brains. Read & Research Alzheimer’s More

Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease">Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease

Cross-sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single positron emission tomography study can provide both functional Read & Research Alzheimer’s More

Ten benefits of shilajit">Ten benefits of shilajit

Shilajit, also called mineral pitch, is the result of a long process of breaking down plant matter and minerals. Learn about the potential health benefits. Read & Research Alzheimer’s More

Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice">Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice

Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration. Read & Research Alzheimer’s More

Does traumatic brain injury hold the key to the Alzheimer's puzzle?">Does traumatic brain injury hold the key to the Alzheimer's puzzle?

Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer’s disease (AD) share many overlapping pathologies and possible clinical links. Read & Research Alzheimer’s More

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology">The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

An animal model of late-onset Alzheimer’s disease is needed to research what causes degeneration in the absence of dominant genetic insults and why the association cortex is particularly vulnerable to degeneration. Read & Research Alzheimer’s More

Canola oil may worsen memory">Canola oil may worsen memory

A diet supplemented with canola oil worsened memory and led to weight gain in mouse models of Alzheimer’s disease, researchers report. Read & Research Alzheimer’s More

Could an existing oxygen therapy treat Alzheimer's?">Could an existing oxygen therapy treat Alzheimer's?

Researchers have shown that hyperbaric oxygen therapy alleviates some physical and behavioral symptoms of Alzheimer’s in a mouse model of the disease. Read & Research Alzheimer’s More

Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States">Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States

We forecast the prevalence of preclinical and clinical Alzheimer’s disease (AD) and evaluated potential impacts of primary and secondary preventions in the United States. Read & Research Alzheimer’s More

Alzheimer's brain damage halved with gene-targeting compound">Alzheimer's brain damage halved with gene-targeting compound

Scientists have designed a molecule that can interfere with the production of the APOE protein. Mouse tests reveal that the compound prevents brain damage. Read & Research Alzheimer’s More

BMI: A double-edged sword in your risk of dementia">BMI: A double-edged sword in your risk of dementia

A global study of more than 1 million people reveals how obesity in midlife and being underweight near onset are both linked to raised risk of dementia. Read & Research Alzheimer’s More