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Estimation of lifetime risks of Alzheimer's disease dementia using biomarkers for preclinical disease">Estimation of lifetime risks of Alzheimer's disease dementia using biomarkers for preclinical disease

Lifetime risks are the probabilities of progressing to Alzheimer’s disease (AD) dementia during one’s lifespan. Here, we report the first estimates of the lifetime and ten-year risks of AD dementia based on age, gender, and biomarker tests for preclinical disease. Read & Research Alzheimer’s More

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1">Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

Genome-wide association studies consistently show that single nucleotide polymorphisms (SNPs) in the complement receptor 1 (CR1) gene modestly but significantly alter Alzheimer’s disease (AD) risk. Follow-up research has assumed that CR1 is expressed in the human brain despite a paucity of evidence for its function there. Alternatively, erythrocytes contain >80% Read & Research Alzheimer’s More

APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies">APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Read & Research Alzheimer’s More

$414 million Alzheimer's and dementia research funding increase signed into law">$414 million Alzheimer's and dementia research funding increase signed into law

In March, a $414 million increase for Alzheimer’s disease (AD) and dementia research funding at the National Institutes of Health and Kevin and Avonte’s Law, important legislation to protect those who wander, were signed into law. Read & Research Alzheimer’s More

Parkinson's, dementia: Is this the key to preventive therapy?">Parkinson's, dementia: Is this the key to preventive therapy?

A landmark study sheds light on the underlying mechanisms that impact neural health in Parkinson’s disease and dementia. Can it lead to better treatments? Read & Research Alzheimer’s More

Cholesterol found to play a role in Alzheimer's">Cholesterol found to play a role in Alzheimer's

According to the latest study, cholesterol plays a role in the formation of plaques in Alzheimer’s disease. The findings open new avenues for drug design. Read & Research Alzheimer’s More

New dementia risk factors uncovered">New dementia risk factors uncovered

Using machine learning techniques, researchers reveal new dementia risks. They conclude that marital status, BMI, and sleep may all play a role. Read & Research Alzheimer’s More

The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies">The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies

Recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies and clinical trials limit the development of new treatments. Widespread Internet use allows data capture from participants in an unsupervised setting. The Brain Health Registry, a website and online registry, collects data from participants and their study partners. Read & Research Alzheimer’s More

Alzheimer's: Are changes in the brain's attention hub at fault?">Alzheimer's: Are changes in the brain's attention hub at fault?

As we grow older, we find it harder to stay focused, perhaps due to changes in the brain’s attention hub. Could this also drive the onset of Alzheimer’s? Read & Research Alzheimer’s More

Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials">Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

We conducted Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. Read & Research Alzheimer’s More

Even mild TBI might raise dementia risk">Even mild TBI might raise dementia risk

A study that followed more than 350,000 veterans found a raised risk of dementia in those who had had TBI — even mild TBI without loss of consciousness. Read & Research Alzheimer’s More

New molecule may stop Alzheimer's from spreading">New molecule may stop Alzheimer's from spreading

Researchers have found a small molecule that can block the spread of the toxic protein tau, a hallmark of Alzheimer’s progression. Read & Research Alzheimer’s More

Fractal regulation and incident Alzheimer's disease in elderly individuals">Fractal regulation and incident Alzheimer's disease in elderly individuals

Healthy physiological systems exhibit fractal regulation (FR), generating similar fluctuation patterns in physiological outputs across different time scales. FR in motor activity is degraded in dementia, and the degradation correlates to cognitive decline. We tested whether degraded FR predicts Alzheimer’s disease dementia. Read & Research Alzheimer’s More

Could anxiety lead to dementia?">Could anxiety lead to dementia?

New research suggests that moderate to severe anxiety in midlife may be an independent risk factor for developing dementia in old age. Read & Research Alzheimer’s More

Alzheimer's: 'Music may make symptoms more manageable'">Alzheimer's: 'Music may make symptoms more manageable'

Alzheimer’s disease can cause people living with it to experience severe anxiety as they try to navigate an unfamiliar world. Can music help them to cope? Read & Research Alzheimer’s More

These common drugs may raise your risk of dementia">These common drugs may raise your risk of dementia

A new study links long-term anticholinergic use for depression, Parkinson’s, and loss of bladder control to raised risk of dementia up to 20 years later. Read & Research Alzheimer’s More

Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia">Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia

The aim of this study was to investigate the association between acetylcholinesterase inhibitor (AChEI) use and risk of ischemic stroke and death in people with dementia. Read & Research Alzheimer’s More

Cognitive decline: Impaired sense of smell could be used as marker">Cognitive decline: Impaired sense of smell could be used as marker

The first population study of sense of smell and cognitive performance by age suggests that testing sense of smell could be a marker for cognitive decline. Read & Research Alzheimer’s More

Could eating fish stave off Parkinson's disease?">Could eating fish stave off Parkinson's disease?

We know that eating fish protects brain health. A new study identifies the protein responsible for this and explains how it fights ‘Parkinson’s protein.’ Read & Research Alzheimer’s More

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Described by poet Carl Sandburg as the “City of Big Shoulders,” Chicago will host a big conference July 22-26: the Alzheimer’s Association International Conference® 2018 (AAIC®). AAIC is the world’s largest gathering of Alzheimer’s and dementia researchers, drawing more than 5,000 attendees from over 70 countries in 2017. Register now Read & Research Alzheimer’s More

Accelerating Alzheimer's disease drug innovations from the research pipeline to patients">Accelerating Alzheimer's disease drug innovations from the research pipeline to patients

In June 2017, a diverse group of experts in Alzheimer’s disease convened to discuss how to accelerate getting new drugs to patients to both prevent and treat the disease. Participants concluded that we need a more robust, diversified drug development pipeline. Strategic policy measures can help keep new Alzheimer’s disease Read & Research Alzheimer’s More

Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians">Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians

Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. Read & Research Alzheimer’s More