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Accelerating Alzheimer's disease drug innovations from the research pipeline to patients">Accelerating Alzheimer's disease drug innovations from the research pipeline to patients

In June 2017, a diverse group of experts in Alzheimer’s disease convened to discuss how to accelerate getting new drugs to patients to both prevent and treat the disease. Participants concluded that we need a more robust, diversified drug development pipeline. Strategic policy measures can help keep new Alzheimer’s disease Read & Research Alzheimer’s More

Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians">Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians

Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. Read & Research Alzheimer’s More

ALS: How 'toxic' proteins could protect neurons">ALS: How 'toxic' proteins could protect neurons

Researchers have found that large, fibrous aggregates thought to drive Lou Gehrig’s disease might actually help to protect motor neurons. Read & Research Alzheimer’s More

How the brain's 'immune memory' may lead to Alzheimer's">How the brain's 'immune memory' may lead to Alzheimer's

A new study shows that the brain’s immune cells retain a memory of previous inflammation, which causes them to react differently to toxic brain proteins. Read & Research Alzheimer’s More

Erratum">Erratum

In the March 2018 issue of Alzheimer’s & Dementia, the article “2018 Alzheimer’s Disease Facts and Figures” incorrectly reported the estimated total lifetime cost of care (including Medicare, Medicaid, out-of-pocket expenditures, and the value of informal care) per person with dementia. The correct cost is estimated at $341,840 in 2017 Read & Research Alzheimer’s More

Just one night of bad sleep increases Alzheimer's protein">Just one night of bad sleep increases Alzheimer's protein

A study reveals that levels of a protein called beta-amyloid — which is associated with Alzheimer’s — increase after a single night of sleep deprivation. Read & Research Alzheimer’s More

Breakthrough: Researchers fix Alzheimer's gene">Breakthrough: Researchers fix Alzheimer's gene

In a first-of-its kind study, scientists use human neurons to study and correct the damaging effects of the APOE4 gene, a well-known genetic risk factor. Read & Research Alzheimer’s More

Alzheimer's: Scientists find the cause of evening agitation">Alzheimer's: Scientists find the cause of evening agitation

A new study in mice shows that manipulating a biological clock circuit alters patterns of aggressiveness that mimic those of humans with Alzheimer’s. Read & Research Alzheimer’s More

Blood test detects Alzheimer's before symptoms appear">Blood test detects Alzheimer's before symptoms appear

Combining antibody technology and an infrared sensor, a groundbreaking test could make the early detection of Alzheimer’s disease a possibility. Read & Research Alzheimer’s More

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?">Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

One characteristic of Alzheimer’s disease is the formation of amyloid-β plaques, which are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and infiltrating immune cells. Here, we describe nonneurogenic doublecortin (DCX) positive cells, DCX being generally used as a marker for young immature neurons, at sites Read & Research Alzheimer’s More

Coffee may worsen Alzheimer's symptoms">Coffee may worsen Alzheimer's symptoms

Coffee is often hailed for its health benefits, but new research finds that long-term consumption could be more of a hindrance for people with Alzheimer’s. Read & Research Alzheimer’s More

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography">Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

We examined and compared plasma phospho-tau181 (pTau181) and total tau: (1) across the Alzheimer’s disease (AD) clinical spectrum; (2) in relation to brain amyloid β (Aβ) positron emission tomography (PET), tau PET, and cortical thickness; and (3) as a screening tool for elevated brain Aβ. Read & Research Alzheimer’s More

Low dopamine may indicate early Alzheimer's">Low dopamine may indicate early Alzheimer's

Scientists find that a lack of dopamine in the brain may cause some of the earliest symptoms of Alzheimer’s disease, a condition with growing prevalence. Read & Research Alzheimer’s More

Identifying dementia cases with routinely collected health data: A systematic review">Identifying dementia cases with routinely collected health data: A systematic review

Prospective, population-based studies can be rich resources for dementia research. Follow-up in many such studies is through linkage to routinely collected, coded health-care data sets. We evaluated the accuracy of these data sets for dementia case identification. Read & Research Alzheimer’s More

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease">Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

Neuroimaging modalities can measure different aspects of the disease process in Alzheimer’s disease, although the relationship between these modalities is unclear. Read & Research Alzheimer’s More

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease">Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease

The ability of Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid β peptide 1–42, total tau, and phosphorylated tau) to discriminate AD from related disorders is limited. Biomarkers for other concomitant pathologies (e.g., CSF α-synuclein [α-syn] for Lewy body pathology) may be needed to further improve the differential diagnosis. Read & Research Alzheimer’s More

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials">European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

It is a challenge to find participants for Alzheimer’s disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer’s Dementia Registry aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Read & Research Alzheimer’s More

Ibuprofen could stop Alzheimer's, say researchers">Ibuprofen could stop Alzheimer's, say researchers

Researchers claim that taking the common anti-inflammatory drug ibuprofen every day from the age of 55 could prevent Alzheimer’s disease. Read & Research Alzheimer’s More

Alzheimer's: This protein may halt brain injury">Alzheimer's: This protein may halt brain injury

A study shows how an antibody that targets the APOE protein halved brain levels of plaque in mice with Alzheimer’s disease without harming APOE in the blood. Read & Research Alzheimer’s More

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease">Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer’s disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Read & Research Alzheimer’s More

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease">Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease

Individuals in early stages of Alzheimer’s disease are a targeted population for secondary prevention trials aimed at preserving normal cognition. Understanding within-person biomarker(s) change over time is critical for trial enrollment and design. Read & Research Alzheimer’s More

Can beets tackle Alzheimer's at its root?">Can beets tackle Alzheimer's at its root?

Harmful formations in the brains of people with Alzheimer’s might be responsible for much of the neural damage. Can a beet-derived pigment prevent the harm? Read & Research Alzheimer’s More

Detecting agitation and aggression in people with dementia using sensors—A systematic review">Detecting agitation and aggression in people with dementia using sensors—A systematic review

Agitation and aggression are among the most challenging symptoms of dementia. Agitated persons with dementia can harm themselves, their caregivers, or other patients in a care facility. Automatic detection of agitation would be useful to alert caregivers so that appropriate interventions can be performed. The building blocks in the automatic Read & Research Alzheimer’s More

Intelligent and effective informatic deconvolution of “Big Data” and its future impact on the quantitative nature of neurodegenerative disease therapy">Intelligent and effective informatic deconvolution of “Big Data” and its future impact on the quantitative nature of neurodegenerative disease therapy

Biomedical data sets are becoming increasingly larger and a plethora of high-dimensionality data sets (“Big Data”) are now freely accessible for neurodegenerative diseases, such as Alzheimer’s disease. It is thus important that new informatic analysis platforms are developed that allow the organization and interrogation of Big Data resources into a Read & Research Alzheimer’s More

High fitness may slash dementia risk, study says">High fitness may slash dementia risk, study says

A new study from Sweden asks whether the level of physical fitness at middle age could influence women’s risk of developing dementia later in life. Read & Research Alzheimer’s More

Apolipoprotein E genotypes and longevity across dementia disorders">Apolipoprotein E genotypes and longevity across dementia disorders

The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer’s disease (AD), but its implication in other dementias is less well studied. Read & Research Alzheimer’s More