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Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa">Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa

Primary age-related tauopathy (PART) is characterized by the presence of neurofibrillary tangles and absent-minimal β-amyloid deposition. Transactive response DNA-binding protein of 43 kDa (TDP-43), a third protein, has recently garnished a lot of attention in Alzheimer’s disease where it is associated with memory loss and amygdala and hippocampal atrophy. We aimed Read & Research Alzheimer’s More

Urate and risk of Alzheimer's disease and vascular dementia: A population-based study">Urate and risk of Alzheimer's disease and vascular dementia: A population-based study

Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia. Read & Research Alzheimer’s More

Experts draft guidelines for Alzheimer's-like condition">Experts draft guidelines for Alzheimer's-like condition

Experts have defined an under-recognized, newly named condition that mimics Alzheimer’s disease and propose guidelines for diagnosing and researching it. Read & Research Alzheimer’s More

Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials">Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Read & Research Alzheimer’s More

Inflammatory biomarkers in Alzheimer's disease plasma">Inflammatory biomarkers in Alzheimer's disease plasma

Plasma biomarkers for Alzheimer’s disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there are no well-established plasma markers. Read & Research Alzheimer’s More

Scientists confirm blood test could track Alzheimer's disease">Scientists confirm blood test could track Alzheimer's disease

Data from up to 11 years of blood samples confirm neurofilament light protein as a potential noninvasive marker of Alzheimer’s disease progression. Read & Research Alzheimer’s More

Mitigating stigma of Alzheimer's disease dementia among Chinese Americans">Mitigating stigma of Alzheimer's disease dementia among Chinese Americans

We read with great interest the article by Stites et al. [1] and commend the authors for analyzing stigma of dementia among 317 adults from the US general public. Their study showed that 55% respondents expected a person with dementia to be discriminated by his/her employers, and approximately 46% respondents expected Read & Research Alzheimer’s More

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations">Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations

Cerebral small vessel disease (cSVD) comprises pathological processes of the small vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or gait disturbance. It is generally accepted that endothelial dysfunction, including blood-brain barrier (BBB) failure, is pivotal in the pathophysiology. Recent years have seen increasing use Read & Research Alzheimer’s More

Can a blood pressure drug protect the brain from Parkinson's?">Can a blood pressure drug protect the brain from Parkinson's?

At blood levels that are typical in humans, an approved high blood pressure drug was able to clear toxic proteins of Parkinson’s disease from mouse brains. Read & Research Alzheimer’s More

A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment">A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

Unlike for glucose, uptake of the brain’s main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Read & Research Alzheimer’s More

Aaron Klug and the study of Alzheimer's disease">Aaron Klug and the study of Alzheimer's disease

Aaron Klug, who died on November 20, 2018, was a giant of molecular biology [1–3]. He was also a major figure in the study of dementia, especially Alzheimer’s disease. In 1982, Aaron was the sole recipient of the Nobel Prize in Chemistry “for his development of crystallographic electron microscopy and Read & Research Alzheimer’s More

Alzheimer's: Synthetic protein blocks toxic beta-amyloid">Alzheimer's: Synthetic protein blocks toxic beta-amyloid

Scientists have designed a protein that folds into alpha sheets that can block toxic beta-amyloid in brain cells before it forms into large clumps. Read & Research Alzheimer’s More

Dementia: Paradigm shifting into high gear">Dementia: Paradigm shifting into high gear

Redressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug “silver bullet”. Read & Research Alzheimer’s More

Erratum to “Validation of a simple severity scale for assessing ARIA-E” [Alzheimer’s & Dementia 2017;13:P253-4.]">Erratum to “Validation of a simple severity scale for assessing ARIA-E” [Alzheimer’s & Dementia 2017;13:P253-4.]

In the abstract “Validation of a simple severity scale for assessing ARIA-E,” published in the July 2017 Supplement issue of Alzheimer’s & Dementia, the values in the first column of Table 1 were incorrectly listed as “mm” instead of “cm.” The corrected table is below. Read & Research Alzheimer’s More

Syncing brain waves may fight age-related memory problems">Syncing brain waves may fight age-related memory problems

Working memory tends to decline with age, and this problem is characterized by poor synchronicity between brain regions. Can researchers ‘fix’ this issue? Read & Research Alzheimer’s More

Dementia: Amyloid PET scans can improve diagnosis and care">Dementia: Amyloid PET scans can improve diagnosis and care

Using brain scans that can detect hallmarks of Alzheimer’s could improve diagnosis and clinical care of people with dementia and mild cognitive impairment. Read & Research Alzheimer’s More

Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease">Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease

Numerous omics studies have been conducted to understand the molecular networks involved in Alzheimer’s disease (AD), but the pathophysiology is still not completely understood; new approaches that enable neuroscientists to better interpret the results of omics analysis are required. Read & Research Alzheimer’s More

This drug failed to treat cancer, but it could improve dementia">This drug failed to treat cancer, but it could improve dementia

Scientists have found that an experimental drug that failed against cancer may treat dementia instead. However, can they test it in clinical trials? Read & Research Alzheimer’s More

Smoking may not be related to dementia risk after all">Smoking may not be related to dementia risk after all

Study of 531 cognitively healthy older adults over 11.5 years finds no link between smoking and dementia after accounting for ‘competing risk’ of death. Read & Research Alzheimer’s More

Is this a better way to deliver drugs to the brain?">Is this a better way to deliver drugs to the brain?

According to a new study in mice, shorter-wave ultrasound pulses could help scientists deliver drugs straight into the brain more safely and efficiently. Read & Research Alzheimer’s More

The key to brain health: Light but frequent exercise">The key to brain health: Light but frequent exercise

New research shows that light and moderate exercise benefits the brain both immediately and in the long run, providing a person is active frequently. Read & Research Alzheimer’s More

Erratum to “Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease—An emerging role for gut microbiome” [Alzheimer’s & Dementia 2019;15:76-92.]">Erratum to “Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease—An emerging role for gut microbiome” [Alzheimer’s & Dementia 2019;15:76-92.]

In the article “Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease—An emerging role for gut microbiome,” published in the January 2019 issue of Alzheimer’s & Dementia, the e-mail address listed for author Rima Kaddurah-Daouk is incorrect. The correct addresses are kaddu001@mc.duke.edu and rima.kaddurahdaouk@duke.edu. Read & Research Alzheimer’s More

Study links severe gum disease to raised dementia risk">Study links severe gum disease to raised dementia risk

Another study has linked chronic periodontitis to higher dementia risk. However, it is the first to show that the link is independent of lifestyle factors. Read & Research Alzheimer’s More

Light and sound therapy may boost brain function">Light and sound therapy may boost brain function

New evidence suggests that a combined light and sound stimulation therapy could boost brain health and improve the symptoms of Alzheimer’s disease. Read & Research Alzheimer’s More

Alzheimer's disease: An eye test could provide early warning">Alzheimer's disease: An eye test could provide early warning

One day, a quick eye test may be able to pick up important information about brain health. Specifically, it may be able to identify signs of dementia. Read & Research Alzheimer’s More

Does eating mushrooms protect brain health?">Does eating mushrooms protect brain health?

Mushrooms are tasty and nutritious, but can they protect the brain from cognitive decline? That is what researchers from Singapore aim to find out. Read & Research Alzheimer’s More

Impact of Helicobacter pylori and/or Helicobacter pylori–related metabolic syndrome on incidence of all-cause and Alzheimer's dementia">Impact of Helicobacter pylori and/or Helicobacter pylori–related metabolic syndrome on incidence of all-cause and Alzheimer's dementia

Beydoun et al. [1], investigated in a large national retrospective cohort study the association of Helicobacter pylori (Hp) seropositivity with an incidence of all-cause and Alzheimer’s disease (AD) dementia and with AD dementia mortality. Data were extracted from the National Health and Nutrition Surveys III, phase 1 (1988–1991), and 1999–2000 and Read & Research Alzheimer’s More