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Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease">Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer’s disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Read & Research Alzheimer’s More

Secular trends in cognitive trajectories of diverse older adults">Secular trends in cognitive trajectories of diverse older adults

This study aimed to determine if later birth year influences trajectory of age-related cognitive decline across racial/ethnic groups and to test whether years of school, childhood socioeconomic status, and cardiovascular disease burden explain such secular trends. Read & Research Alzheimer’s More

Dementia risk higher in those who eat more trans fats">Dementia risk higher in those who eat more trans fats

A new study of 1,628 older people living in Japan found a 52–74% higher chance of developing dementia in those with higher blood levels of trans fats. Read & Research Alzheimer’s More

How a high salt diet may lead to cognitive decline">How a high salt diet may lead to cognitive decline

New research in mice sheds light on the mechanism that explains the causal link between a diet high in salt and a marker of Alzheimer’s disease. Read & Research Alzheimer’s More

Amyloid pathology–produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites">Amyloid pathology–produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites

Alzheimer’s disease (AD) is linked to neuronal calcium dyshomeostasis, which is associated with network hyperexcitability. Decreased expression of the calcium-binding protein calbindin-D28K (CB) might be a susceptibility factor for AD. The subiculum is affected early in AD, for unknown reasons. Read & Research Alzheimer’s More

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias">Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD). Read & Research Alzheimer’s More

Failed dementia drug gets a second chance">Failed dementia drug gets a second chance

Biotech company Biogen have announced that they will file for official approval of a new Alzheimer’s drug, while results in clinical trials were uncertain. Read & Research Alzheimer’s More

What is apraxia?">What is apraxia?

Apraxia is a neurological disorder that affects a person’s ability to perform everyday movements. Learn more about the symptoms, causes, and types in this article. Read & Research Alzheimer’s More

Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes">Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes

Sensor-based assessment of challenging behaviors in dementia may be useful to support caregivers. Here, we investigated accelerometry as tool for identification and prediction of challenging behaviors. Read & Research Alzheimer’s More

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures">New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed. Read & Research Alzheimer’s More

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies">Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Understanding the heterogeneous pathology in Alzheimer’s disease and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease-modifying therapies. Through monitoring ensembles of toxic and nontoxic tau oligomers spontaneously formed in cells, our biosensor technology can identify tool compounds that modulate tau oligomer Read & Research Alzheimer’s More

Heart and brain health are connected, but what influences both?">Heart and brain health are connected, but what influences both?

A new study in twins finds that modifiable factors, such as early family life, may be more important than genes in driving heart and brain health outcomes. Read & Research Alzheimer’s More

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology">The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

It is important to establish the natural history of familial frontotemporal lobar degeneration (f-FTLD) and provide clinical and biomarker data for planning these studies, particularly in the asymptomatic phase. Read & Research Alzheimer’s More

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study">Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study

Multiple immunity biomarkers have been suggested as tracers of neuroinflammation in neurodegeneration. This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer’s disease (AD) and Parkinson’s disease (PD) subjects from the network of the European, Innovative Medicines Initiative–funded project AETIONOMY. Read & Research Alzheimer’s More

Dementia: Brain mapping method may predict progression">Dementia: Brain mapping method may predict progression

New research shows how frontotemporal dementia progresses and enables scientists to accurately predict how the condition will spread. Read & Research Alzheimer’s More

MCI: Should memory tests score males and females differently?">MCI: Should memory tests score males and females differently?

A new study finds that testing memory with sex-specific scores could lead to more females and fewer males receiving a mild cognitive impairment diagnosis. Read & Research Alzheimer’s More

Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people">Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people

Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. Read & Research Alzheimer’s More

What to know about acetylcholine">What to know about acetylcholine

Acetylcholine is a neurotransmitter that plays a key role in brain and muscle function. Here, we look at what acetylcholine does and describe medical conditions linked with it, including Alzheimer’s and Parkinson’s, and their treatments. Read & Research Alzheimer’s More

Alzheimer's disease: Brain immune cells may offer new treatment target">Alzheimer's disease: Brain immune cells may offer new treatment target

A new study attributes the link between tau protein clumping and brain damage in Alzheimer’s disease to brain immune cells called microglia. Read & Research Alzheimer’s More

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics">Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics

Although the relationship between APOE and Alzheimer’s disease (AD) is well established in populations of European descent, the effects of APOE and ancestry on AD risk in diverse populations is not well understood. Read & Research Alzheimer’s More

Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos">Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos

To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Read & Research Alzheimer’s More

Existing blood thinner delays Alzheimer's disease in mice">Existing blood thinner delays Alzheimer's disease in mice

New research in mice suggests that dabigatran, a blood thinning drug, may help delay the development of Alzheimer’s by maintaining normal brain blood flow. Read & Research Alzheimer’s More

Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial">Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial

Alzheimer’s disease (AD) is a disabling, common cause of dementia, and agitation is one of the most common and distressing symptoms for patients with AD. Escitalopram for agitation in Alzheimer’s disease (S-CitAD) tests a novel, clinically derived therapeutic approach to treat agitation in patients with AD. Read & Research Alzheimer’s More

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults">Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer’s disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study. Read & Research Alzheimer’s More

Declining incidence of dementia: A national registry-based study over 20 years">Declining incidence of dementia: A national registry-based study over 20 years

The aim of this study was to investigate the registry-based national time trends in incidence and prevalence rates of dementia from 1996 to 2015. Read & Research Alzheimer’s More

95% of people think they could develop dementia with age">95% of people think they could develop dementia with age

A large scale global study from ADI and the London School of Economics and Political Science examines the attitudes of people toward dementia. Read & Research Alzheimer’s More

Alcohol and dementia risk: A complex relationship">Alcohol and dementia risk: A complex relationship

The relationship between alcohol consumption and dementia risk in older adults is proving difficult to unpick. A recent study takes a fresh look. Read & Research Alzheimer’s More