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Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people">Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people

Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. Read & Research Alzheimer’s More

What to know about acetylcholine">What to know about acetylcholine

Acetylcholine is a neurotransmitter that plays a key role in brain and muscle function. Here, we look at what acetylcholine does and describe medical conditions linked with it, including Alzheimer’s and Parkinson’s, and their treatments. Read & Research Alzheimer’s More

Alzheimer's disease: Brain immune cells may offer new treatment target">Alzheimer's disease: Brain immune cells may offer new treatment target

A new study attributes the link between tau protein clumping and brain damage in Alzheimer’s disease to brain immune cells called microglia. Read & Research Alzheimer’s More

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics">Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics

Although the relationship between APOE and Alzheimer’s disease (AD) is well established in populations of European descent, the effects of APOE and ancestry on AD risk in diverse populations is not well understood. Read & Research Alzheimer’s More

Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos">Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos

To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Read & Research Alzheimer’s More

Existing blood thinner delays Alzheimer's disease in mice">Existing blood thinner delays Alzheimer's disease in mice

New research in mice suggests that dabigatran, a blood thinning drug, may help delay the development of Alzheimer’s by maintaining normal brain blood flow. Read & Research Alzheimer’s More

Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial">Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial

Alzheimer’s disease (AD) is a disabling, common cause of dementia, and agitation is one of the most common and distressing symptoms for patients with AD. Escitalopram for agitation in Alzheimer’s disease (S-CitAD) tests a novel, clinically derived therapeutic approach to treat agitation in patients with AD. Read & Research Alzheimer’s More

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults">Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer’s disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study. Read & Research Alzheimer’s More

Declining incidence of dementia: A national registry-based study over 20 years">Declining incidence of dementia: A national registry-based study over 20 years

The aim of this study was to investigate the registry-based national time trends in incidence and prevalence rates of dementia from 1996 to 2015. Read & Research Alzheimer’s More

95% of people think they could develop dementia with age">95% of people think they could develop dementia with age

A large scale global study from ADI and the London School of Economics and Political Science examines the attitudes of people toward dementia. Read & Research Alzheimer’s More

Alcohol and dementia risk: A complex relationship">Alcohol and dementia risk: A complex relationship

The relationship between alcohol consumption and dementia risk in older adults is proving difficult to unpick. A recent study takes a fresh look. Read & Research Alzheimer’s More

Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?">Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?

The 2018 National Institute on Aging and the Alzheimer’s Association (NIA-AA) research framework recently redefined Alzheimer’s disease (AD) as a biological construct, based on in vivo biomarkers reflecting key neuropathologic features. Combinations of normal/abnormal levels of three biomarker categories, based on single thresholds, form the AD signature profile that defines the Read & Research Alzheimer’s More

New approach may save brain cells in neurodegenerative diseases">New approach may save brain cells in neurodegenerative diseases

Neuron damage and death in Alzheimer’s and other neurodegenerative diseases may be preventable by targeting a shared cause of inflammation. Read & Research Alzheimer’s More

Fluctuating blood pressure may speed up cognitive decline in Alzheimer's">Fluctuating blood pressure may speed up cognitive decline in Alzheimer's

New evidence suggests that managing blood pressure may help slow down the progression of cognitive decline in people with Alzheimer’s disease. Read & Research Alzheimer’s More

Walking patterns may help differentiate types of dementia">Walking patterns may help differentiate types of dementia

A new study suggests that people with Lewy body dementia and Alzheimer’s have distinct walking patterns that may match cognitive and disease changes. Read & Research Alzheimer’s More

Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent">Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent

Questions remain about whether apolipoprotein E (APOE)-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains. Read & Research Alzheimer’s More

Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status">Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status

The Multidomain Alzheimer Preventive Trial (MAPT) assessed the efficacy of omega-3 fatty acid supplementation, a multidomain intervention (MI), or a combination of both on cognition. Impact according to cerebral amyloid status was evaluated by PET scan. Read & Research Alzheimer’s More

Alzheimer's: Head device reduces memory loss in 7 out of 8 people">Alzheimer's: Head device reduces memory loss in 7 out of 8 people

A clinical trial has found that an innovative electromagnetic therapy device significantly reduced memory loss in seven out of the eight participants. Read & Research Alzheimer’s More

Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?">Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?

We aimed to refine the hypothesis that dementia has a unique signature of gait impairment reflective of underlying pathology by considering two dementia subtypes, Alzheimer’s disease (AD) and Lewy body disease (LBD), and exploring the role of cognition in disease-specific gait impairments. Read & Research Alzheimer’s More

Can exercise slow down Alzheimer's?">Can exercise slow down Alzheimer's?

A new proof-of-concept study finds that people with Alzheimer’s biomarkers in the brain who exercise frequently experience slower deterioration. Read & Research Alzheimer’s More

How to care for someone with Alzheimer's disease">How to care for someone with Alzheimer's disease

Caring for someone with Alzheimer’s disease can be both challenging and rewarding. Learn about tips to make it easier, as well as when to seek professional help. Read & Research Alzheimer’s More

Hearing aids lower the chance of dementia, depression, and falling">Hearing aids lower the chance of dementia, depression, and falling

A recent study concludes that wearing hearing aids is associated with later onset of dementia and a reduced risk of anxiety, depression, and falls. Read & Research Alzheimer’s More

Migraine may raise dementia, Alzheimer's risk">Migraine may raise dementia, Alzheimer's risk

New research finds a ‘significant’ association between a history of migraine and various forms of dementia, and Alzheimer’s disease in particular. Read & Research Alzheimer’s More

The Alzheimer's Disease Exposome">The Alzheimer's Disease Exposome

Environmental factors are poorly understood in the etiology of Alzheimer’s disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants. Read & Research Alzheimer’s More

Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study">Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study

Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. Read & Research Alzheimer’s More

Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review">Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review

Individuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late-onset Alzheimer’s disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk. These “resilient” individuals may carry protective genetic factors. Read & Research Alzheimer’s More