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Future of Alzheimer's therapy: What is the best approach?">Future of Alzheimer's therapy: What is the best approach?

A new comprehensive review assesses current clinical trials for Alzheimer’s drugs and advises on the best therapeutic approach going forward. Read & Research Alzheimer’s More

A new blood test could help diagnose Alzheimer's">A new blood test could help diagnose Alzheimer's

New research focuses on an accurate blood test for Alzheimer’s disease. If scientists replicate the study’s promising results, it may be a breakthrough. Read & Research Alzheimer’s More

Dementia: Gene study boosts search for treatment">Dementia: Gene study boosts search for treatment

Using an innovative analytical approach, researchers pinpointed genes that play an important role in the protein buildup associated with dementia. Read & Research Alzheimer’s More

Alzheimer's Association Update">Alzheimer's Association Update

The Alzheimer’s Association, in partnership with the Global Brain Health Institute (GBHI) and Alzheimer’s Society (UK), has awarded 21 grants totaling more than $500,000 that aim to improve quality of life for people affected by Alzheimer’s disease and dementia. The Pilot Awards for Global Brain Health Leaders program supports emerging Read & Research Alzheimer’s More

Gun ownership and dementia: A growing concern">Gun ownership and dementia: A growing concern

As the older population of the United States grows, the prevalence of dementia also rises. A new paper discusses dementia and gun ownership. Read & Research Alzheimer’s More

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease">Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer’s disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model mice. Read & Research Alzheimer’s More

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome">Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

Down syndrome (DS) is associated with an almost universal development of Alzheimer’s disease. Individuals with DS are therefore an important population for randomized controlled trials to prevent or delay cognitive decline, though it is essential to understand the time course of early cognitive changes. Read & Research Alzheimer’s More

Lung disease may increase dementia risk">Lung disease may increase dementia risk

New research uncovers another potential risk factor for dementia and, more generally, for cognitive impairment, namely having a lung disease in midlife. Read & Research Alzheimer’s More

Alzheimer's may soon be treated with HIV drugs">Alzheimer's may soon be treated with HIV drugs

For the first time, scientists show how the gene that produces brain toxicity in Alzheimer’s is ‘recombined’ using the same enzyme found in HIV. Read & Research Alzheimer’s More

Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016">Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016

Thank you for inviting us to respond to the letter from Wilkinson et al. [1] about our recent article on in-hospital diagnosis of dementia. [2] We found that dementia diagnosis was recorded in only 63% of admissions of people with previously diagnosed dementia to a general hospital and that there were Read & Research Alzheimer’s More

Men who eat lots of fruits and vegetables have less memory loss">Men who eat lots of fruits and vegetables have less memory loss

Consumption of orange juice, certain vegetables, leafy greens, and berry fruits is tied to less memory loss in a large group of men followed for 26 years. Read & Research Alzheimer’s More

Could managing cholesterol prevent Alzheimer's?">Could managing cholesterol prevent Alzheimer's?

The largest genetic study of Alzheimer’s to date finds that this neurological disease shares some genetic risk factors with several cardiovascular conditions. Read & Research Alzheimer’s More

Alzheimer's vaccine draws closer">Alzheimer's vaccine draws closer

Building on more than a decade of scientific research, a recent paper brings us one step closer to developing a vaccine for Alzheimer’s disease. Read & Research Alzheimer’s More

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease">Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease

Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer’s disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Read & Research Alzheimer’s More

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis">A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis

Nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer’s disease pathologic changes. We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer’s disease. Read & Research Alzheimer’s More

A simple type of daily meditation may alter the course of Alzheimer's">A simple type of daily meditation may alter the course of Alzheimer's

Simple mind-body practices altered potential cell aging and Alzheimer’s biomarkers. The changes linked directly to improved cognition and other functions. Read & Research Alzheimer’s More

Parkinson's disease: Scientists find new target to destroy protein clumps">Parkinson's disease: Scientists find new target to destroy protein clumps

In Parkinson’s disease, toxic protein clumps accumulate in the brain’s motor region. A study shows how targeting an enzyme could prevent this. Read & Research Alzheimer’s More

The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach">The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach

Like virtually all age-related chronic diseases, late-onset Alzheimer’s disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a Read & Research Alzheimer’s More

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2">Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

Murine microglia expressing the Alzheimer’s disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microglia. Therefore, we created human pluripotent stem cell (hPSC) monocytes and transdifferentiated microglia-like cells (tMGs) to examine the effect of the Read & Research Alzheimer’s More

How a key protein boosts memory, learning in the adult brain">How a key protein boosts memory, learning in the adult brain

New research reveals that a protein that helps make connections between neurons in the developing infant brain also strengthens them in the adult brain. Read & Research Alzheimer’s More

Military-related risk factors for dementia">Military-related risk factors for dementia

In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer’s disease in veterans. Read & Research Alzheimer’s More

Alzheimer's: Artificial intelligence predicts onset">Alzheimer's: Artificial intelligence predicts onset

A deep learning algorithm trained to analyze brain scans accurately predicted who would develop Alzheimer’s more than 6 years before diagnosis. Read & Research Alzheimer’s More

How coffee protects the brain">How coffee protects the brain

New research reveals what gives coffee its protective properties for brain health, and why it can help keep Alzheimer’s and Parkinson’s disease at bay. Read & Research Alzheimer’s More