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Repairing leaky blood-brain barrier may rejuvenate brain function">Repairing leaky blood-brain barrier may rejuvenate brain function

New research in mice suggests that a leaky blood-brain barrier can accelerate brain aging, and that targeting inflammation can reverse some changes. Read & Research Alzheimer’s More

Alzheimer's risk gene and heavy metal exposure may impair cognition">Alzheimer's risk gene and heavy metal exposure may impair cognition

New research in mice suggests that exposure to cadmium can lead to cognitive decline in those with the Alzheimer’s risk gene APOE4. Read & Research Alzheimer’s More

What to know about CoQ10 and its dosage">What to know about CoQ10 and its dosage

CoQ10 is a natural chemical that carries out a many vital roles in the body. Some people may take supplements to correct a CoQ10 deficiency. Read & Research Alzheimer’s More

Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube">Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube

The ROADMAP project aimed to provide an integrated overview of European real-world data on Alzheimer’s disease (AD) across the disease spectrum. Read & Research Alzheimer’s More

Neuropsychological decline up to 20 years before incident mild cognitive impairment">Neuropsychological decline up to 20 years before incident mild cognitive impairment

Some Alzheimer’s disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment Read & Research Alzheimer’s More

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study">Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study

Observational studies have suggested that light-to-moderate alcohol consumption decreases the risk of Alzheimer’s disease, but it is unclear if this association is causal. Read & Research Alzheimer’s More

Extra virgin olive oil may protect against various dementias">Extra virgin olive oil may protect against various dementias

A new study in mice finds that extra virgin olive oil prevents the toxic accumulation of tau protein in the brain and keeps memory intact. Read & Research Alzheimer’s More

Incidence of frontotemporal disorders in Olmsted County: A population-based study">Incidence of frontotemporal disorders in Olmsted County: A population-based study

Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Read & Research Alzheimer’s More

Tau-positron emission tomography correlates with neuropathology findings">Tau-positron emission tomography correlates with neuropathology findings

Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Read & Research Alzheimer’s More

Inflammation drives tau damage in Alzheimer's">Inflammation drives tau damage in Alzheimer's

Inflammation drives neuron damage by tau protein accumulation in Alzheimer’s and other neurodegenerative brain diseases, according to new research. Read & Research Alzheimer’s More

Alzheimer's: Poor air quality may contribute to cognitive decline">Alzheimer's: Poor air quality may contribute to cognitive decline

A recent study adds to the evidence linking air pollution with cognitive decline. The researchers also suggest a possible underlying mechanism. Read & Research Alzheimer’s More

A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL-INCA)">A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL-INCA)

Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer’s disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay Read & Research Alzheimer’s More

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD">Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD

Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. Read & Research Alzheimer’s More

Study finds no link between statin use and memory harm in older adults">Study finds no link between statin use and memory harm in older adults

A 6-year study of 1,000 people aged 70–90 found no difference in rates of memory or cognition decline among participants who did or did not use statins. Read & Research Alzheimer’s More

Illiteracy may triple dementia risk">Illiteracy may triple dementia risk

New research finds that people who cannot read may have a threefold risk of developing dementia in older age, compared with people who can read. Read & Research Alzheimer’s More

Why is my leg shaking?">Why is my leg shaking?

There are many reasons a person’s leg could be shaking, from restless legs syndrome to anxiety. Read this article to learn about 10 possible causes of a shaky leg. Read & Research Alzheimer’s More

Retinal imaging shows promise in early detection of Alzheimer's">Retinal imaging shows promise in early detection of Alzheimer's

A study of 35 people with and without Alzheimer’s disease found that hyperspectral imaging of the retina could aid early diagnosis of the disease. Read & Research Alzheimer’s More

Scientists propose new theory of Parkinson's disease">Scientists propose new theory of Parkinson's disease

In a new review of the evidence, scientists propose two main types of Parkinson’s, depending on which part of the nervous system the disease originates in. Read & Research Alzheimer’s More

Does childhood cognition predict dementia risk later in life?">Does childhood cognition predict dementia risk later in life?

New research examines the cognitive ability of children in the hope that markers of cognitive decline will predict dementia later in life. Read & Research Alzheimer’s More

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis">The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

Development of disease-modifying treatments for Alzheimer’s disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, Read & Research Alzheimer’s More

Does waist size predict dementia risk?">Does waist size predict dementia risk?

The first large-scale study of its kind examines the link between waist circumference in later life and the risk of developing dementia. Read & Research Alzheimer’s More

How waste gets 'washed out' of our brains during sleep">How waste gets 'washed out' of our brains during sleep

A new study shows, for the first time, that cerebrospinal fluid washes into and out of the brain in waves during sleep, helping clear out waste. Read & Research Alzheimer’s More

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease">C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer’s disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid β (Aβ) contribute to the onset of AD. Read & Research Alzheimer’s More

Intact global cognitive and olfactory ability predicts lack of transition to dementia">Intact global cognitive and olfactory ability predicts lack of transition to dementia

Odor identification deficits characterize Alzheimer’s disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Read & Research Alzheimer’s More

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease">Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer’s disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Read & Research Alzheimer’s More