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Alzheimer's: Death of key brain cells causes daytime sleepiness">Alzheimer's: Death of key brain cells causes daytime sleepiness

According to a new study, the buildup of toxic tau protein in key areas of the brain leads to major brain cell loss and daytime sleepiness in Alzheimer’s. Read & Research Alzheimer’s More

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota">Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Gut microbiota changes before the onset of Alzheimer’s disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. Read & Research Alzheimer’s More

How to improve your memory: 8 techniques to try">How to improve your memory: 8 techniques to try

Brain function and memory naturally decline slightly as a person ages, but there are many techniques people can use to improve memory and prevent its loss. Learn about them here. Read & Research Alzheimer’s More

Social activity in your 60s may lower dementia risk by 12%">Social activity in your 60s may lower dementia risk by 12%

One of the most reliable studies of its kind has tracked participants over a 28-year period and found that greater social activity can lower dementia risk. Read & Research Alzheimer’s More

Neuropsychological latent classes at enrollment and postmortem neuropathology">Neuropsychological latent classes at enrollment and postmortem neuropathology

We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Read & Research Alzheimer’s More

Blood test can identify Alzheimer's 2 decades before symptoms">Blood test can identify Alzheimer's 2 decades before symptoms

A new study showcases a blood test that identifies beta-amyloid proteins — a hallmark of Alzheimer’s disease — 20 years before any symptoms of dementia. Read & Research Alzheimer’s More

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life">Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life

There is keen interest in elucidating the biological mechanisms underlying recent failures of β-site amyloid precursor protein–cleaving enzyme-1 (BACE1) inhibitors in Alzheimer’s disease trials. Read & Research Alzheimer’s More

Profound degeneration of wake-promoting neurons in Alzheimer's disease">Profound degeneration of wake-promoting neurons in Alzheimer's disease

Sleep-wake disturbances are a common and early feature in Alzheimer’s disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Read & Research Alzheimer’s More

18F-FDG PET, the early phases and the delivery rate of 18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against 15O-H2O PET">18F-FDG PET, the early phases and the delivery rate of 18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against 15O-H2O PET

Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer’s disease (AD). The purpose of this study was to validate the perfusion components of early-phase 18F-florbetapir (eAV45), the 18F-AV45 delivery rate (R1), and 18F-FDG against 15O-H2O PET and assess Read & Research Alzheimer’s More

7 'simple' steps for heart health may also stave off dementia">7 'simple' steps for heart health may also stave off dementia

New research examines the link between heart health at 50 years of age, and the risk of developing dementia 25 years later, on average. Read & Research Alzheimer’s More

Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework">Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework

We develop a framework to model disease progression across Alzheimer’s disease (AD) and to assess the cost-effectiveness of future disease-modifying therapies (DMTs) for people with mild cognitive impairment (MCI) due to AD. Read & Research Alzheimer’s More

Traumatic brain injury and Alzheimer's disease neuropathology">Traumatic brain injury and Alzheimer's disease neuropathology

Traumatic brain injury (TBI) as a risk factor for the development of late-life dementia, including Alzheimer’s disease (AD), is a matter of discussion [1–4], and only a few studies examined the potential relationship between residual TBI lesions and AD neuropathology [5–9]. Examining 4761 deceased participants from the National Alzheimer’s Coordination Read & Research Alzheimer’s More

Alzheimer's: Researchers create model to predict decline">Alzheimer's: Researchers create model to predict decline

Researchers have developed a new machine-learning model that they suggest can accurately predict a person’s Alzheimer’s-related cognitive decline. Read & Research Alzheimer’s More

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome">Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

The corticobasal syndrome (CBS) is associated with several neuropathologic disorders, including corticobasal degeneration and Alzheimer’s disease (AD). Read & Research Alzheimer’s More

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study">Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study

We aimed to estimate the frequency of each AT(N) (β-amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group. Read & Research Alzheimer’s More

'New wave of Alzheimer's research' looks to the liver for clues">'New wave of Alzheimer's research' looks to the liver for clues

Specialists call for a more holistic approach to Alzheimer’s research, taking in the brain’s relationship with other organs, including the liver. Read & Research Alzheimer’s More

Could dementia and anemia be linked?">Could dementia and anemia be linked?

A new study has found a strong association between anemia and dementia. People with either high or low hemoglobin levels had a higher risk. Read & Research Alzheimer’s More

Persistent impact of housing loss on cognitive decline after the 2011 Great East Japan earthquake and tsunami: Evidence from a 6-year longitudinal study">Persistent impact of housing loss on cognitive decline after the 2011 Great East Japan earthquake and tsunami: Evidence from a 6-year longitudinal study

We previously established that housing loss and residential dislocation in the 2011 Japan earthquake and tsunami was a risk factor for cognitive decline among older survivors. The present study extends the follow-up of survivors out to 6 years. Read & Research Alzheimer’s More

Study links higher body weight later in life to faster brain aging">Study links higher body weight later in life to faster brain aging

A new study has found a correlation between having a higher body mass index and waist circumference later in life, and a faster rate of brain aging. Read & Research Alzheimer’s More

Is spicy food linked to dementia risk?">Is spicy food linked to dementia risk?

According to a large new longitudinal study, people who eat a lot of hot chili in their daily diet may have a higher risk of cognitive decline. Read & Research Alzheimer’s More

Alzheimer's: Common gene explains why some drugs fail">Alzheimer's: Common gene explains why some drugs fail

A new study helps to explain why some Alzheimer’s drugs work in some people but not in others, and why some yet may succeed in animals but not in humans. Read & Research Alzheimer’s More

Computer use later in life may prevent cognitive decline">Computer use later in life may prevent cognitive decline

New research finds that using a computer and playing games, among other activities, can significantly reduce the risk of mild cognitive impairment. Read & Research Alzheimer’s More

Genes vs. lifestyle: Study 'undermines fatalistic view of dementia'">Genes vs. lifestyle: Study 'undermines fatalistic view of dementia'

New research suggests that making healthful lifestyle choices can offset the genetic risk of developing Alzheimer’s and other forms of dementia. Read & Research Alzheimer’s More

How having a close relative with Alzheimer's may affect cognition">How having a close relative with Alzheimer's may affect cognition

New research suggests that having a relative with Alzheimer’s disease may put people at risk of a premature decline in memory and learning. Read & Research Alzheimer’s More

Alzheimer's: Cell mechanism removes defective protein">Alzheimer's: Cell mechanism removes defective protein

Buildup of defective tau protein is a hallmark of Alzheimer’s disease. Now, scientists have identified a molecule that helps clear it from brain cells. Read & Research Alzheimer’s More

Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging">Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging

Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Read & Research Alzheimer’s More

Alzheimer's blood test almost 'usable in routine clinical care'">Alzheimer's blood test almost 'usable in routine clinical care'

A new blood test for detecting Alzheimer’s disease approaches ‘a level of accuracy that is usable in routine clinical care around the world.’ Read & Research Alzheimer’s More