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How frontotemporal dementia affects 'moral emotions'">How frontotemporal dementia affects 'moral emotions'

Scientists find a key difference between Alzheimer’s and frontotemporal dementia: the latter affects a person’s ‘moral emotions’ while the former does not. Read & Research Alzheimer’s More

How is education linked to Alzheimer's progress?">How is education linked to Alzheimer's progress?

New research asks to what extent, if any, a person’s level of education is linked to the presence of Alzheimer’s disease and the rate of cognitive decline. Read & Research Alzheimer’s More

Contributions of vascular and Alzheimer's disease pathology to dementia">Contributions of vascular and Alzheimer's disease pathology to dementia

Although Alzheimer’s disease (AD) is frequently cited as the most common type of dementia, the relative contributions of vascular and neurodegenerative pathology to clinical dementia have been actually obscure. The systematic review of studies reporting clinicopathologic data of dementia cases sheds important light on this issue [1]. Ten reports were Read & Research Alzheimer’s More

A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal magnetic resonance imaging data">A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal magnetic resonance imaging data

It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer’s disease (AD) dementia. Read & Research Alzheimer’s More

How ultrasound could help curb Parkinson's">How ultrasound could help curb Parkinson's

Mouse study shows that focused ultrasound and injected microbubbles can help curb early Parkinson’s disease by allowing drugs to access the brain. Read & Research Alzheimer’s More

Parkinson's: New gene therapy shows promise for prevention">Parkinson's: New gene therapy shows promise for prevention

Researchers from Japan have tested a new gene therapy against Parkinson’s disease using mouse models. Their results suggest that the approach is effective. Read & Research Alzheimer’s More

Can blood pressure drugs help reduce dementia risk?">Can blood pressure drugs help reduce dementia risk?

A large study analyzing the medical data of thousands of people suggests that dementia incidence is lower among those who take blood pressure medication. Read & Research Alzheimer’s More

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation">Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation

A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer’s disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer’s Disease [PREVENT-AD]). Read & Research Alzheimer’s More

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease">Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

Neuroimaging biomarkers are important for early diagnosis of Alzheimer’s disease, and comparing multimodality neuroimaging to autopsy data is essential. Read & Research Alzheimer’s More

Is virtual reality the next frontier of Alzheimer's diagnosis?">Is virtual reality the next frontier of Alzheimer's diagnosis?

New research suggests that using a virtual reality simulator could be more effective at detecting Alzheimer’s disease than standard tests. Read & Research Alzheimer’s More

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype">Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer’s disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Read & Research Alzheimer’s More

Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study">Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study

To report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait. Read & Research Alzheimer’s More

Virus 'identity change' may play a role in Alzheimer's">Virus 'identity change' may play a role in Alzheimer's

A study using human biological samples and mouse models has found what can make viruses more dangerous and how some could facilitate Alzheimer’s. Read & Research Alzheimer’s More

Early-onset Alzheimer's: Is 'bad cholesterol' a factor?">Early-onset Alzheimer's: Is 'bad cholesterol' a factor?

A new study connects high blood levels of ‘bad’ cholesterol with the presence of early-onset Alzheimer’s. The link, the authors suggest, could be causal. Read & Research Alzheimer’s More

How do we recall the past? New mechanism revealed">How do we recall the past? New mechanism revealed

A brain study in rats that explored different environments reveals that the anterior cingulate cortex drives the hippocampus in long-term memory recall. Read & Research Alzheimer’s More

Alzheimer's: Brain changes may occur 34 years before symptoms">Alzheimer's: Brain changes may occur 34 years before symptoms

New research finds that some Alzheimer’s-related biomarkers in the brain change as early as 34 years before the onset of visible symptoms. Read & Research Alzheimer’s More

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease">Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer’s disease are poorly understood. Read & Research Alzheimer’s More

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease">Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

Blood-based biomarkers of pathophysiological brain amyloid β (Aβ) accumulation, particularly for preclinical target and large-scale interventions, are warranted to effectively enrich Alzheimer’s disease clinical trials and management. Read & Research Alzheimer’s More

Dementia: New WHO prevention guidelines evaluate 12 risk factors">Dementia: New WHO prevention guidelines evaluate 12 risk factors

The WHO have recently released a new set of guidelines around strategies for dementia prevention, in which they evaluate potential interventions. Read & Research Alzheimer’s More

Virtual reality may help stimulate memory in people with dementia">Virtual reality may help stimulate memory in people with dementia

According to a recent study, virtual reality might provide a useful tool for treating dementia. Among other things, it may help improve memory. Read & Research Alzheimer’s More

Novel Alzheimer's drug passes first phase of human testing">Novel Alzheimer's drug passes first phase of human testing

A drug that tackles toxic protein buildup in Alzheimer’s disease in a novel way has passed phase 1 of clinical trials, which tests safety in humans. Read & Research Alzheimer’s More

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint">Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

Identifying clinical measures that track disease in the earliest stages of frontotemporal lobar degeneration (FTLD) is important for clinical trials. Familial FTLD provides a unique paradigm to study early FTLD. Executive dysfunction is a clinically relevant hallmark of FTLD and may be a marker of disease progression. Read & Research Alzheimer’s More

Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology">Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology

18F-florbetaben is currently approved for the visual rule out of β-amyloid (Aβ) pathology. It is also used for recruitment and as an outcome measure in therapeutic trials, requiring accurate and reproducible quantification of Aβ burden in the brain. Read & Research Alzheimer’s More

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort">Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

A critical and as-yet unmet need in Alzheimer’s disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Read & Research Alzheimer’s More

Alzheimer's: How light therapy could protect the brain">Alzheimer's: How light therapy could protect the brain

A study uncovers the neuron and immune cell changes that explain why light therapy can reduce toxic brain proteins in mouse models of Alzheimer’s disease. Read & Research Alzheimer’s More

The MOPEAD project: Advancing patient engagement for the detection of “hidden” undiagnosed cases of Alzheimer's disease in the community">The MOPEAD project: Advancing patient engagement for the detection of “hidden” undiagnosed cases of Alzheimer's disease in the community

In most, if not all health systems, dementia is underdiagnosed, and when diagnosis occurs, it is typically at a relatively late stage in the disease process despite mounting evidence showing that a timely diagnosis would result in numerous benefits for patients, families, and society. Moving toward earlier diagnoses in Alzheimer’s Read & Research Alzheimer’s More

Could a cell phone game detect who is at risk of Alzheimer's?">Could a cell phone game detect who is at risk of Alzheimer's?

According to a new study, a cell phone game called ‘Sea Hero Quest’ could assist researchers in identifying people who are more at risk of Alzheimer’s. Read & Research Alzheimer’s More

Erratum to “Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice” [Alzheimer’s & Dementia 2016;12:1273-87.]">Erratum to “Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice” [Alzheimer’s & Dementia 2016;12:1273-87.]

In the article “Kallikrein-8 inhibition attenuates Alzheimer’s disease pathology in mice,” published in the December 2016 issue of Alzheimer’s & Dementia, the authors would like to amend the Acknowledgments section to include the contributions of Constanze Roggendorf, Anthony Stang, and Ilkay Yavuz. Read & Research Alzheimer’s More