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Could an epilepsy drug help to slow Alzheimer's?">Could an epilepsy drug help to slow Alzheimer's?

A drug used to reduce seizures has been found to normalize brain wave frequencies in patients with Alzheimer’s. Could this drug help to slow the disease? Read & Research Alzheimer’s More

Leisure activities lower blood pressure in Alzheimer's caregivers">Leisure activities lower blood pressure in Alzheimer's caregivers

Going for a walk outside, reading, listening to music — these and other enjoyable activities can reduce blood pressure for elderly caregivers of spouses with Alzheimer’s disease, suggests a study in… Read & Research Alzheimer’s More

Computer-designed antibodies target toxins associated with Alzheimer's disease">Computer-designed antibodies target toxins associated with Alzheimer's disease

Researchers at the University of Cambridge have designed antibodies that target the protein deposits in the brain associated with Alzheimer’s disease, and stop their production. Read & Research Alzheimer’s More

African plant extract offers new hope for Alzheimer's">African plant extract offers new hope for Alzheimer's

A plant extract used for centuries in traditional medicine in Nigeria could form the basis of a new drug to treat Alzheimer’s disease, researchers at The University of Nottingham have found. Read & Research Alzheimer’s More

Extra-virgin olive oil may prevent Alzheimer's">Extra-virgin olive oil may prevent Alzheimer's

A new study investigates the effect of extra-virgin olive oil on cognitive decline and brain inflammation in people with Alzheimer’s disease. Read & Research Alzheimer’s More

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline">Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline

The study investigated the role of neuropathologies in the relationship between TOMM40 ‘523 genotype and late-life cognitive decline. Read & Research Alzheimer’s More

Study identifies potential biomarker for Alzheimer's disease">Study identifies potential biomarker for Alzheimer's disease

In one of the largest studies to date to use metabolomics, the study of compounds that are created through various chemical reactions in the body, researchers have been able to identify new… Read & Research Alzheimer’s More

Western diet increases Alzheimer's pathology in genetically predisposed mice">Western diet increases Alzheimer's pathology in genetically predisposed mice

Obese mice with a particular version of a gene strongly associated with Alzheimer’s disease (AD) in humans show increased Alzheimer’s pathology, according to new research published in eNeuro. Read & Research Alzheimer’s More

Microvascular changes in Down syndrome with Alzheimer-type pathology: Insights into a potential vascular mechanism for Down syndrome and Alzheimer's disease">Microvascular changes in Down syndrome with Alzheimer-type pathology: Insights into a potential vascular mechanism for Down syndrome and Alzheimer's disease

The mechanism triggering degeneration in Alzheimer’s disease (AD) remains uncertain. Therapeutic failure following β amyloid (Aβ) removal casts doubt on amyloid neurotoxicity per se as the primary cause of AD. Impaired microvascular function has been suggested as an alternative etiology. People with Down syndrome (DS) develop Alzheimer pathology, but whether Read & Research Alzheimer’s More

Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study">Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study

Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. Read & Research Alzheimer’s More

Post-traumatic stress disorder and risk of dementia among members of a health care delivery system">Post-traumatic stress disorder and risk of dementia among members of a health care delivery system

Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little is known in females and civilians. Read & Research Alzheimer’s More

Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study">Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study

With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia Read & Research Alzheimer’s More

Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study">Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study

The identification of novel biomarkers associated with Alzheimer’s disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics. Read & Research Alzheimer’s More

Head or brain injuries and Alzheimer's disease: A nested case-control register study">Head or brain injuries and Alzheimer's disease: A nested case-control register study

Many previous studies have been limited by self- or proxy-reported injury or short follow-up. We investigated whether head or brain injuries are associated with Alzheimer’s disease (AD), possible modifying factors and dose-response relationship. Read & Research Alzheimer’s More

Chronic pain linked to increased risk of dementia in study of older adults">Chronic pain linked to increased risk of dementia in study of older adults

Researchers at UC San Francisco have found that older people with persistent pain show quicker declines in memory as they age and are more likely to have dementia years later, an indication that… Read & Research Alzheimer’s More

Objective features of subjective cognitive decline in a US national database">Objective features of subjective cognitive decline in a US national database

Functional and cognitive features of subjective cognitive decline (SCD) were identified in a longitudinal database from the National Alzheimer Coordinating Center. Read & Research Alzheimer’s More

Detecting Alzheimer's disease before symptoms emerge">Detecting Alzheimer's disease before symptoms emerge

Long before symptoms of Alzheimer’s disease become apparent to patients and their families, biological changes are occurring within the brain. Read & Research Alzheimer’s More

Researchers discover new 'GPS' neuron">Researchers discover new 'GPS' neuron

An international research team led by UvA researchers Jeroen Bos, Martin Vinck and Cyriel Pennartz has identified a new type of neuron which might play a vital role in humans’ ability to navigate… Read & Research Alzheimer’s More

Dementia prevalence, care arrangement, and access to care in Lebanon">Dementia prevalence, care arrangement, and access to care in Lebanon

In North Africa and the Middle East, studies about dementia prevalence are scarce. The Arabic-validated 10/66 Dementia Research Group diagnostic assessment was used to assess the prevalence of dementia in Lebanon in a population-based study. The study also examined care arrangement and access to care. Read & Research Alzheimer’s More

Alzheimer's disease: Family history may explain puzzling link to metabolic gene">Alzheimer's disease: Family history may explain puzzling link to metabolic gene

Research linking the metabolic gene TOMM40 with Alzheimer’s risk has produced mixed results for years. Now, a new study says family history is the reason. Read & Research Alzheimer’s More

Can Omega-3 help prevent Alzheimer's disease? Brain spect imaging shows possible link">Can Omega-3 help prevent Alzheimer's disease? Brain spect imaging shows possible link

Neuroimaging shows increased blood flow in regions of the brain associated with memory and learning for people with higher omega-3 levels, according to a new report in the Journal of Alzheimer’s… Read & Research Alzheimer’s More

Family history and TOMM40 ‘523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts">Family history and TOMM40 ‘523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts

Family history (FH) of Alzheimer’s disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 (‘523) poly-T length on memory decline. Read & Research Alzheimer’s More

Diagnostic biomarkers in saliva show promise in recognizing early Alzheimer's disease">Diagnostic biomarkers in saliva show promise in recognizing early Alzheimer's disease

Your spit may hold a clue to future brain health. Investigators at the Beaumont Research Institute, part of Beaumont Health in Michigan, are hopeful that their study involving small molecules in… Read & Research Alzheimer’s More

Tau prevents synaptic transmission at early stage of neurodegeneration">Tau prevents synaptic transmission at early stage of neurodegeneration

Tau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia. Read & Research Alzheimer’s More

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability">Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability

Tau-mediated toxicity in Alzheimer’s disease is thought to operate through low-n oligomers, rather than filamentous aggregates. However, the nature of oligomers and pathways of toxicity are poorly understood. Therefore, we investigated structural and functional aspects of highly purified oligomers of a pro-aggregant tau species. Read & Research Alzheimer’s More

Research reveals new insights into early cognitive markers of Alzheimer's disease">Research reveals new insights into early cognitive markers of Alzheimer's disease

New research led by the University of Hertfordshire, may significantly change the understanding of cognitive processes that are most impaired at very early stages of Alzheimer’s disease. Read & Research Alzheimer’s More