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Could some antibiotics help treat early onset dementia?">Could some antibiotics help treat early onset dementia?

A preclinical study using cell cultures has found that some antibiotics may help address a genetic mutation associated with forms of early onset dementia. Read & Research Alzheimer’s More

What to know about brain atrophy">What to know about brain atrophy

Brain atrophy can refer to a loss of brain cells or a loss in the number of connections between these cells. In this article, learn about the symptoms of brain atrophy, as well as some causes and treatments. Read & Research Alzheimer’s More

Could hydration levels influence cognitive function?">Could hydration levels influence cognitive function?

A new study found a link between inadequate hydration and poorer cognitive functioning, especially in memory and attention tasks — but only in older women. Read & Research Alzheimer’s More

What causes Alzheimer's? Not toxic amyloid, new study suggests">What causes Alzheimer's? Not toxic amyloid, new study suggests

The findings of a new study suggest that the accumulation of toxic beta-amyloid proteins in the brain may not be the cause of Alzheimer’s disease. Read & Research Alzheimer’s More

Scientists draw closer to a dementia vaccine">Scientists draw closer to a dementia vaccine

A new mouse study uses a two-pronged approach to designing a vaccine for dementia. The results are encouraging, and a clinical trial may be on the horizon. Read & Research Alzheimer’s More

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease">Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease

We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer’s disease (EOAD and LOAD). Read & Research Alzheimer’s More

Dementia: Obesity, but not diet or inactivity, raises risk">Dementia: Obesity, but not diet or inactivity, raises risk

New research suggests that it may only be obesity, not a poor diet or lack of physical activity, that contributes to dementia risk. Read & Research Alzheimer’s More

Inflammatory marker could be early warning for dementia">Inflammatory marker could be early warning for dementia

New research identifies an inflammatory biomarker in the blood, called sCD14, that may predict someone’s risk of developing clinical dementia. Read & Research Alzheimer’s More

How two experimental Alzheimer's drugs reverse aging">How two experimental Alzheimer's drugs reverse aging

New research in mice reveals the molecular and genetic mechanisms through which two Alzheimer’s drug candidates can reverse aging in general. Read & Research Alzheimer’s More

Mouse study tests a novel approach against Alzheimer's">Mouse study tests a novel approach against Alzheimer's

In a mouse study, researchers have tested the potential of a ketone ester-rich diet in slowing down Alzheimer’s, and have found this approach promising. Read & Research Alzheimer’s More

Transport breakdown in brain cells may lead to Alzheimer's, Parkinson's">Transport breakdown in brain cells may lead to Alzheimer's, Parkinson's

New research in mice and flies suggests that failure to transport molecules that break down proteins in neurons may lead to neurodegenerative diseases. Read & Research Alzheimer’s More

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele">Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

We previously characterized associations between brain imaging measurements of amyloid-β (Aβ) plaque burden and apolipoprotein E (APOE) ϵ4 gene dose in a small number of cognitively unimpaired late-middle-aged APOE ϵ4 homozygotes (HMs), heterozygotes (HTs), and noncarriers (NCs). We now characterize cross-sectional Aβ plaque, tau tangle, and cortical atrophy (neurodegeneration) measurements, Read & Research Alzheimer’s More

Repairing leaky blood-brain barrier may rejuvenate brain function">Repairing leaky blood-brain barrier may rejuvenate brain function

New research in mice suggests that a leaky blood-brain barrier can accelerate brain aging, and that targeting inflammation can reverse some changes. Read & Research Alzheimer’s More

Alzheimer's risk gene and heavy metal exposure may impair cognition">Alzheimer's risk gene and heavy metal exposure may impair cognition

New research in mice suggests that exposure to cadmium can lead to cognitive decline in those with the Alzheimer’s risk gene APOE4. Read & Research Alzheimer’s More

What to know about CoQ10 and its dosage">What to know about CoQ10 and its dosage

CoQ10 is a natural chemical that carries out a many vital roles in the body. Some people may take supplements to correct a CoQ10 deficiency. Read & Research Alzheimer’s More

Neuropsychological decline up to 20 years before incident mild cognitive impairment">Neuropsychological decline up to 20 years before incident mild cognitive impairment

Some Alzheimer’s disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment Read & Research Alzheimer’s More

Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube">Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube

The ROADMAP project aimed to provide an integrated overview of European real-world data on Alzheimer’s disease (AD) across the disease spectrum. Read & Research Alzheimer’s More

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study">Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study

Observational studies have suggested that light-to-moderate alcohol consumption decreases the risk of Alzheimer’s disease, but it is unclear if this association is causal. Read & Research Alzheimer’s More

Extra virgin olive oil may protect against various dementias">Extra virgin olive oil may protect against various dementias

A new study in mice finds that extra virgin olive oil prevents the toxic accumulation of tau protein in the brain and keeps memory intact. Read & Research Alzheimer’s More

Tau-positron emission tomography correlates with neuropathology findings">Tau-positron emission tomography correlates with neuropathology findings

Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Read & Research Alzheimer’s More

Incidence of frontotemporal disorders in Olmsted County: A population-based study">Incidence of frontotemporal disorders in Olmsted County: A population-based study

Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Read & Research Alzheimer’s More

Inflammation drives tau damage in Alzheimer's">Inflammation drives tau damage in Alzheimer's

Inflammation drives neuron damage by tau protein accumulation in Alzheimer’s and other neurodegenerative brain diseases, according to new research. Read & Research Alzheimer’s More

Alzheimer's: Poor air quality may contribute to cognitive decline">Alzheimer's: Poor air quality may contribute to cognitive decline

A recent study adds to the evidence linking air pollution with cognitive decline. The researchers also suggest a possible underlying mechanism. Read & Research Alzheimer’s More

A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL-INCA)">A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL-INCA)

Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer’s disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay Read & Research Alzheimer’s More

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD">Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD

Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. Read & Research Alzheimer’s More

Study finds no link between statin use and memory harm in older adults">Study finds no link between statin use and memory harm in older adults

A 6-year study of 1,000 people aged 70–90 found no difference in rates of memory or cognition decline among participants who did or did not use statins. Read & Research Alzheimer’s More