Fuck Alzheimer's

A number of risk factors are known for dementia; these include hypertension, a sedentary lifestyle, obesity, and smoking. A new study may add another. Read & Research Alzheimer’s More

We tested the hypothesis that low plasma complement C3 is observationally and genetically associated with high risk of Alzheimer’s disease. Read & Research Alzheimer’s More

We sought to examine the genetic overlap between vascular pathologies and Alzheimer’s disease (AD) dementia, and the potential mediating role of vascular pathologies between AD-related genetic variants and late-life cognition. Read & Research Alzheimer’s More

In 2016, the UC Davis Latino Aging Research Resource Center and UC Davis Alzheimer’s Disease Center brought together experts from across the country to consolidate current knowledge and identify future directions in aging and diversity research. This report disseminates the research priorities that emerged from this conference, building on an Read & Research Alzheimer’s More

The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). Read & Research Alzheimer’s More

Several concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been Read & Research Alzheimer’s More

According to a new study, there may be a link between daytime sleepiness and an increased risk of developing Alzheimer’s later in life. Read & Research Alzheimer’s More

A new study investigating seasonal variation in cognitive ability concludes that more people reach the threshold for a dementia diagnosis in winter. Read & Research Alzheimer’s More

The trends in prevalence and incidence of Alzheimer’s disease (AD) dementia remain uncertain. Read & Research Alzheimer’s More

Tangles of tau protein are a hallmark of Alzheimer’s disease. Now, scientists have uncovered a new mechanism through which tau disrupts brain cells. Read & Research Alzheimer’s More

A new study provides 10-year estimates for dementia risk, focusing on age, sex, and genetic predisposition. This may lead to early preventive initiatives. Read & Research Alzheimer’s More

An existing drug used to treat liver disease could also be effective in Alzheimer’s disease, researchers find. Better Alzheimer’s therapy is much needed. Read & Research Alzheimer’s More

In the largest analysis of its type to date, researchers conclude that stroke significantly increases the risk of developing dementia in older age. Read & Research Alzheimer’s More

Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. Read & Research Alzheimer’s More

Using an innovative approach, scientists move one step closer to a treatment for Alzheimer’s. Learning how to tame the brain’s immune system is vital. Read & Research Alzheimer’s More

A study of blood flow in 128 brain regions in 30,000 people aged 0–105 years has identified behaviors and disorders that speed up brain aging. Read & Research Alzheimer’s More

A new study links Alzheimer’s toxic waste buildup in the brain to the functioning of the ‘cellular waste removal’ system: the endolysosomal system. Read & Research Alzheimer’s More

In the largest study of its type, researchers conclude that osteoporosis significantly increases the risk of developing dementia. Read & Research Alzheimer’s More

A French study of older adults found that having more modifiable cardiovascular health measures at ‘optimal levels’ was tied to lower risk of dementia. Read & Research Alzheimer’s More

Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here. Read & Research Alzheimer’s More

Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer’s disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Read & Research Alzheimer’s More

A minority of patients with sporadic early-onset Alzheimer’s disease (AD) exhibit de novo germ line mutations in the autosomal dominant genes such as APP, PSEN1, or PSEN2. We hypothesized that negatively screened patients may harbor somatic variants in these genes. Read & Research Alzheimer’s More

The impact of prediabetes and diabetes on cognitive decline and the potential underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes accelerate cognitive decline and brain aging, and the initial pathological changes linked to microvascular processes. Read & Research Alzheimer’s More

The new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer’s disease conceptual models. However, as a “complex” disease, a model based on systems-level understanding is needed to Read & Research Alzheimer’s More

By doubling back and re-examining familiar components of the cell, scientists are finding new ways to approach difficult-to-treat diseases. Read & Research Alzheimer’s More

Identifying ophthalmic diseases associated with increased risk of Alzheimer’s disease (AD) may enable better screening and understanding of those at risk of AD. Read & Research Alzheimer’s More

In the largest study of its type, researchers conclude that older adults who carry more belly fat are more likely to see a reduction in cognitive ability. Read & Research Alzheimer’s More

Two common symptoms in people with dementia are agitation and psychosis. Now, a panel of experts explains how best to manage them, and which drugs do work. Read & Research Alzheimer’s More

Alzheimer’s disease is a progressive neurodegenerative disorder with no known cure. Can an existing drug prevent it from developing in people at high risk? Read & Research Alzheimer’s More

A large study with a follow-up period of 23 years concludes that both long periods of abstinence and long periods of heavy drinking raise dementia risk. Read & Research Alzheimer’s More