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Illiteracy may triple dementia risk">Illiteracy may triple dementia risk

New research finds that people who cannot read may have a threefold risk of developing dementia in older age, compared with people who can read. Read & Research Alzheimer’s More

Why is my leg shaking?">Why is my leg shaking?

There are many reasons a person’s leg could be shaking, from restless legs syndrome to anxiety. Read this article to learn about 10 possible causes of a shaky leg. Read & Research Alzheimer’s More

Retinal imaging shows promise in early detection of Alzheimer's">Retinal imaging shows promise in early detection of Alzheimer's

A study of 35 people with and without Alzheimer’s disease found that hyperspectral imaging of the retina could aid early diagnosis of the disease. Read & Research Alzheimer’s More

Scientists propose new theory of Parkinson's disease">Scientists propose new theory of Parkinson's disease

In a new review of the evidence, scientists propose two main types of Parkinson’s, depending on which part of the nervous system the disease originates in. Read & Research Alzheimer’s More

Does childhood cognition predict dementia risk later in life?">Does childhood cognition predict dementia risk later in life?

New research examines the cognitive ability of children in the hope that markers of cognitive decline will predict dementia later in life. Read & Research Alzheimer’s More

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis">The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

Development of disease-modifying treatments for Alzheimer’s disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, Read & Research Alzheimer’s More

Does waist size predict dementia risk?">Does waist size predict dementia risk?

The first large-scale study of its kind examines the link between waist circumference in later life and the risk of developing dementia. Read & Research Alzheimer’s More

How waste gets 'washed out' of our brains during sleep">How waste gets 'washed out' of our brains during sleep

A new study shows, for the first time, that cerebrospinal fluid washes into and out of the brain in waves during sleep, helping clear out waste. Read & Research Alzheimer’s More

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease">C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer’s disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid β (Aβ) contribute to the onset of AD. Read & Research Alzheimer’s More

Intact global cognitive and olfactory ability predicts lack of transition to dementia">Intact global cognitive and olfactory ability predicts lack of transition to dementia

Odor identification deficits characterize Alzheimer’s disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Read & Research Alzheimer’s More

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease">Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer’s disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Read & Research Alzheimer’s More

Secular trends in cognitive trajectories of diverse older adults">Secular trends in cognitive trajectories of diverse older adults

This study aimed to determine if later birth year influences trajectory of age-related cognitive decline across racial/ethnic groups and to test whether years of school, childhood socioeconomic status, and cardiovascular disease burden explain such secular trends. Read & Research Alzheimer’s More

Dementia risk higher in those who eat more trans fats">Dementia risk higher in those who eat more trans fats

A new study of 1,628 older people living in Japan found a 52–74% higher chance of developing dementia in those with higher blood levels of trans fats. Read & Research Alzheimer’s More

How a high salt diet may lead to cognitive decline">How a high salt diet may lead to cognitive decline

New research in mice sheds light on the mechanism that explains the causal link between a diet high in salt and a marker of Alzheimer’s disease. Read & Research Alzheimer’s More

Amyloid pathology–produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites">Amyloid pathology–produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites

Alzheimer’s disease (AD) is linked to neuronal calcium dyshomeostasis, which is associated with network hyperexcitability. Decreased expression of the calcium-binding protein calbindin-D28K (CB) might be a susceptibility factor for AD. The subiculum is affected early in AD, for unknown reasons. Read & Research Alzheimer’s More

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias">Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD). Read & Research Alzheimer’s More

Failed dementia drug gets a second chance">Failed dementia drug gets a second chance

Biotech company Biogen have announced that they will file for official approval of a new Alzheimer’s drug, while results in clinical trials were uncertain. Read & Research Alzheimer’s More

What is apraxia?">What is apraxia?

Apraxia is a neurological disorder that affects a person’s ability to perform everyday movements. Learn more about the symptoms, causes, and types in this article. Read & Research Alzheimer’s More

Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes">Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes

Sensor-based assessment of challenging behaviors in dementia may be useful to support caregivers. Here, we investigated accelerometry as tool for identification and prediction of challenging behaviors. Read & Research Alzheimer’s More

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures">New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed. Read & Research Alzheimer’s More

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies">Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Understanding the heterogeneous pathology in Alzheimer’s disease and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease-modifying therapies. Through monitoring ensembles of toxic and nontoxic tau oligomers spontaneously formed in cells, our biosensor technology can identify tool compounds that modulate tau oligomer Read & Research Alzheimer’s More

Heart and brain health are connected, but what influences both?">Heart and brain health are connected, but what influences both?

A new study in twins finds that modifiable factors, such as early family life, may be more important than genes in driving heart and brain health outcomes. Read & Research Alzheimer’s More

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology">The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

It is important to establish the natural history of familial frontotemporal lobar degeneration (f-FTLD) and provide clinical and biomarker data for planning these studies, particularly in the asymptomatic phase. Read & Research Alzheimer’s More

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study">Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study

Multiple immunity biomarkers have been suggested as tracers of neuroinflammation in neurodegeneration. This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer’s disease (AD) and Parkinson’s disease (PD) subjects from the network of the European, Innovative Medicines Initiative–funded project AETIONOMY. Read & Research Alzheimer’s More

MCI: Should memory tests score males and females differently?">MCI: Should memory tests score males and females differently?

A new study finds that testing memory with sex-specific scores could lead to more females and fewer males receiving a mild cognitive impairment diagnosis. Read & Research Alzheimer’s More

Dementia: Brain mapping method may predict progression">Dementia: Brain mapping method may predict progression

New research shows how frontotemporal dementia progresses and enables scientists to accurately predict how the condition will spread. Read & Research Alzheimer’s More

Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people">Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people

Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. Read & Research Alzheimer’s More