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Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults">Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer’s disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Read & Research Alzheimer’s More

Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study">Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study

The impact of prediabetes and diabetes on cognitive decline and the potential underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes accelerate cognitive decline and brain aging, and the initial pathological changes linked to microvascular processes. Read & Research Alzheimer’s More

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease">Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease

A minority of patients with sporadic early-onset Alzheimer’s disease (AD) exhibit de novo germ line mutations in the autosomal dominant genes such as APP, PSEN1, or PSEN2. We hypothesized that negatively screened patients may harbor somatic variants in these genes. Read & Research Alzheimer’s More

A systems-based model of Alzheimer's disease">A systems-based model of Alzheimer's disease

The new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer’s disease conceptual models. However, as a “complex” disease, a model based on systems-level understanding is needed to Read & Research Alzheimer’s More

The war on disease: Revisiting old haunts">The war on disease: Revisiting old haunts

By doubling back and re-examining familiar components of the cell, scientists are finding new ways to approach difficult-to-treat diseases. Read & Research Alzheimer’s More

Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease">Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease

Identifying ophthalmic diseases associated with increased risk of Alzheimer’s disease (AD) may enable better screening and understanding of those at risk of AD. Read & Research Alzheimer’s More

Belly fat linked to cognitive decline">Belly fat linked to cognitive decline

In the largest study of its type, researchers conclude that older adults who carry more belly fat are more likely to see a reduction in cognitive ability. Read & Research Alzheimer’s More

Agitation in dementia: Are drugs the best treatment?">Agitation in dementia: Are drugs the best treatment?

Two common symptoms in people with dementia are agitation and psychosis. Now, a panel of experts explains how best to manage them, and which drugs do work. Read & Research Alzheimer’s More

Existing drug may prevent Alzheimer's">Existing drug may prevent Alzheimer's

Alzheimer’s disease is a progressive neurodegenerative disorder with no known cure. Can an existing drug prevent it from developing in people at high risk? Read & Research Alzheimer’s More

Dementia: Both too much and too little alcohol may raise risk">Dementia: Both too much and too little alcohol may raise risk

A large study with a follow-up period of 23 years concludes that both long periods of abstinence and long periods of heavy drinking raise dementia risk. Read & Research Alzheimer’s More

Vitamin D: Recent research uncovers new benefits">Vitamin D: Recent research uncovers new benefits

Vitamin D draws a great deal of scientific attention. In this Spotlight, we delve into recent research and explore the vitamin’s disease-fighting powers. Read & Research Alzheimer’s More

'More potent' Alzheimer's therapy is on its way">'More potent' Alzheimer's therapy is on its way

Researchers identify better techniques for the development of more effective Alzheimer’s therapy. This may allow them to tackle the disease in the brain. Read & Research Alzheimer’s More

Contact sports increase Parkinson's disease risk">Contact sports increase Parkinson's disease risk

Contact sports can lead to brain injury, which is why they are associated with dementia. New research explains why they may also increase Parkinson’s risk. Read & Research Alzheimer’s More

Blocking one enzyme could help treat many chronic disorders">Blocking one enzyme could help treat many chronic disorders

New drugs for diverse inflammatory diseases — from Alzheimer’s and Parkinson’s to cancer and osteoarthritis — may come from the discovery of a new target. Read & Research Alzheimer’s More

Side effects of painkillers are worse in Alzheimer's">Side effects of painkillers are worse in Alzheimer's

New studies conclude that individuals with Alzheimer’s are more sensitive to opioids. Researchers call for a review of how pain medication is given. Read & Research Alzheimer’s More

Feeling dizzy after standing may predict dementia">Feeling dizzy after standing may predict dementia

Feeling dizzy when you stand up — or orthostatic hypotension — might predict the development of dementia in later life, according to a new study. Read & Research Alzheimer’s More

Why smells bring back such vivid memories">Why smells bring back such vivid memories

New research shows how the brain integrates smells with spatiotemporal information to create memories. The findings also shed new light on Alzheimer’s. Read & Research Alzheimer’s More

How liver health impacts the risk of Alzheimer's">How liver health impacts the risk of Alzheimer's

A new factor that may influence the risk of Alzheimer’s has emerged: the liver’s ability to produce enough phospholipids that help protect brain health. Read & Research Alzheimer’s More

Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers">Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Several neurodegenerative brain proteinopathies, including Alzheimer’s disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. Read & Research Alzheimer’s More

How a turmeric compound could treat glaucoma">How a turmeric compound could treat glaucoma

Glaucoma can lead to vision loss, but a turmeric derivative can improve current treatments. New research devises a viable method of adding it to eye drops. Read & Research Alzheimer’s More

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration">Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration

Cerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy. We examined CSF concentrations of total tau (t-tau), phosphorylated tau, and amyloid β1-42 and their association with RHI in former National Football League (NFL) players. The Read & Research Alzheimer’s More

Erratum">Erratum

In the article “Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years,” published in the January 2018 issue of Alzheimer’s & Dementia, several corrections to the article were inadvertently omitted. A revised version of the manuscript is available online at https://doi.org/10.1016/j.jalz.2017.06.2264. Read & Research Alzheimer’s More

Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration">Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration

Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer’s disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suitable for drug screening. To create a new in vitro tauopathy model, we generated a footprint-free triple Read & Research Alzheimer’s More

Molecular imaging in dementia: Past, present, and future">Molecular imaging in dementia: Past, present, and future

Molecular imaging techniques using 18F-fluorodeoxyglucose, amyloid tracers, and, more recently, tau ligands have taken dementia research by storm and undoubtedly improved our understanding of neurodegenerative diseases. The ability to image in vivo the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better Read & Research Alzheimer’s More

Sleep disturbances and dementia risk: A multicenter study">Sleep disturbances and dementia risk: A multicenter study

Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Read & Research Alzheimer’s More

Alzheimer's risk 10 times lower with herpes medication">Alzheimer's risk 10 times lower with herpes medication

New research offers ‘the first population evidence for a causal link’ between herpes infection and the development of Alzheimer’s disease. Read & Research Alzheimer’s More

Vitamin D offers no protection against Alzheimer's">Vitamin D offers no protection against Alzheimer's

Systematic review of clinical studies finds no robust evidence that vitamin D protects the brain against diseases such as Alzheimer’s, MS, and Parkinson’s. Read & Research Alzheimer’s More

High blood pressure may increase dementia risk">High blood pressure may increase dementia risk

A new study looking at links between hypertension in later life and brain health finds an increased risk of Alzheimer’s hallmarks and brain lesions. Read & Research Alzheimer’s More

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale">Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Read & Research Alzheimer’s More

Common cause of dementia may be treatable">Common cause of dementia may be treatable

A study saw that drugs that stabilize the cells lining small blood vessels in the brain reversed symptoms of a common cause of stroke and dementia in rats. Read & Research Alzheimer’s More