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The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach">The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach

Like virtually all age-related chronic diseases, late-onset Alzheimer’s disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a Read & Research Alzheimer’s More

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2">Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

Murine microglia expressing the Alzheimer’s disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microglia. Therefore, we created human pluripotent stem cell (hPSC) monocytes and transdifferentiated microglia-like cells (tMGs) to examine the effect of the Read & Research Alzheimer’s More

How a key protein boosts memory, learning in the adult brain">How a key protein boosts memory, learning in the adult brain

New research reveals that a protein that helps make connections between neurons in the developing infant brain also strengthens them in the adult brain. Read & Research Alzheimer’s More

Military-related risk factors for dementia">Military-related risk factors for dementia

In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer’s disease in veterans. Read & Research Alzheimer’s More

Alzheimer's: Artificial intelligence predicts onset">Alzheimer's: Artificial intelligence predicts onset

A deep learning algorithm trained to analyze brain scans accurately predicted who would develop Alzheimer’s more than 6 years before diagnosis. Read & Research Alzheimer’s More

How coffee protects the brain">How coffee protects the brain

New research reveals what gives coffee its protective properties for brain health, and why it can help keep Alzheimer’s and Parkinson’s disease at bay. Read & Research Alzheimer’s More

Alzheimer's may be treated with diabetes drugs">Alzheimer's may be treated with diabetes drugs

New research suggests that targeting the brain’s capillary cells with antidiabetes drugs may relieve Alzheimer’s-related brain pathologies. Read & Research Alzheimer’s More

Loneliness tied to a higher risk of dementia">Loneliness tied to a higher risk of dementia

A 10-year study of 12,000 diverse older adults finds that loneliness, independently of social isolation, is tied to a 40 percent higher risk of dementia. Read & Research Alzheimer’s More

Eye scan may detect Alzheimer's disease in seconds">Eye scan may detect Alzheimer's disease in seconds

It may soon be possible to diagnose Alzheimer’s in a matter of seconds using a noninvasive eye scanner that simply examines a person’s retina. Read & Research Alzheimer’s More

The signs and symptoms of Parkinson's disease">The signs and symptoms of Parkinson's disease

Parkinson’s disease is a neurological condition that affects a person in many different ways. Tremor is a well-known symptom but not the only one. Find out more. Read & Research Alzheimer’s More

How does stress affect the brain?">How does stress affect the brain?

Stress can affect every aspect of our mental and physical health. A new study now shows just how exposure to stress can impact memory and brain volume. Read & Research Alzheimer’s More

Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife">Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife

This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance in late middle-aged adults enriched for Alzheimer’s disease (AD) risk. Read & Research Alzheimer’s More

Community perceptions related to brain donation: Evidence for intervention">Community perceptions related to brain donation: Evidence for intervention

Research progress on neurocognitive disorders requires donation of both healthy and diseased brains. Here, we describe attitudes toward brain donation among a large community sample in Florida. Read & Research Alzheimer’s More

How you breathe may affect your memory">How you breathe may affect your memory

Do you tend to breathe more through your nose or through your mouth? Your answer may affect your ability to consolidate new memories. Read & Research Alzheimer’s More

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology">Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB–positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. Read & Research Alzheimer’s More

Herpes may account for 50 percent of Alzheimer's cases">Herpes may account for 50 percent of Alzheimer's cases

A large review suggests that the herpes virus may result in a heightened risk of senile dementia, and may account for numerous Alzheimer’s diagnoses. Read & Research Alzheimer’s More

Alzheimer's: These psychiatric symptoms may be an early sign">Alzheimer's: These psychiatric symptoms may be an early sign

A postmortem study of brain tissue tests and interviews of those close to the deceased ties some psychiatric symptoms to early Alzheimer’s disease. Read & Research Alzheimer’s More

AMYPAD Diagnostic and Patient Management Study: Rationale and design">AMYPAD Diagnostic and Patient Management Study: Rationale and design

Reimbursement of amyloid-PET is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. The Amyloid Imaging to Prevent Alzheimer’s Disease–Diagnostic and Patient Management Study (AMYPAD-DPMS) is designed to fill this gap. Read & Research Alzheimer’s More

Communication between specialities of the mind and the body">Communication between specialities of the mind and the body

We read the recent article by Sommerlad et al. [1] with great interest. This important study showed that, for patients aged >65 years who were known to mental health services with a diagnosis of dementia and who were subsequently admitted to a general medical hospital, only 63.3% received a dementia International Classification Read & Research Alzheimer’s More

Keto diet may protect against cognitive decline">Keto diet may protect against cognitive decline

Our diets can influence the state of our health. Research in mice now suggests that one regimen — the ketogenic diet — may even prevent cognitive decline. Read & Research Alzheimer’s More

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers">Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbiota influence pathological features of Alzheimer’s disease (AD) including neuroinflammation and amyloid-β deposition. Read & Research Alzheimer’s More

Antidepressants could stave off dementia">Antidepressants could stave off dementia

The findings of a new study suggest that some antidepressants may block the growth of toxic plaques in the brain, thus helping to treat dementia. Read & Research Alzheimer’s More

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative">Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

The overall goal of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer’s disease (AD) clinical trials. ADNI is a multisite, longitudinal, observational study that has collected many biomarkers since 2004. Recent publications highlight the multifactorial nature of late-onset AD. We discuss selected topics that provide insights Read & Research Alzheimer’s More

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome">Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria. They have major regulatory and Read & Research Alzheimer’s More

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease">CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease

Altered cell cycle reentry has been observed in Alzheimer’s disease (AD). DTL was predicted as the top driver of a cell cycle subnetwork associated with AD. Read & Research Alzheimer’s More

How do hearing and sight influence cognitive decline?">How do hearing and sight influence cognitive decline?

Hearing and sight loss are tied to faster cognitive decline, so does addressing these issues slow down cognitive deterioration? New studies investigate. Read & Research Alzheimer’s More